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The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.

Aminzadeh MA, Reisman SA, Vaziri ND, Khazaeli M, Yuan J, Meyer CJ.

Xenobiotica. 2014 Jun;44(6):570-8. doi: 10.3109/00498254.2013.852705.


The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease.

Aminzadeh MA, Reisman SA, Vaziri ND, Shelkovnikov S, Farzaneh SH, Khazaeli M, Meyer CJ.

Redox Biol. 2013 Oct 31;1:527-31. doi: 10.1016/j.redox.2013.10.007.


Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease.

Vaziri ND, Liu S, Farzaneh SH, Nazertehrani S, Khazaeli M, Zhao YY.

Free Radic Biol Med. 2015 Sep;86:374-81. doi: 10.1016/j.freeradbiomed.2015.04.022.


Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.

Soetikno V, Sari FR, Lakshmanan AP, Arumugam S, Harima M, Suzuki K, Kawachi H, Watanabe K.

Mol Nutr Food Res. 2013 Sep;57(9):1649-59. doi: 10.1002/mnfr.201200540.


Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.

Kim HJ, Vaziri ND.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F662-71. doi: 10.1152/ajprenal.00421.2009.


Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy.

Aminzadeh MA, Nicholas SB, Norris KC, Vaziri ND.

Nephrol Dial Transplant. 2013 Aug;28(8):2038-45. doi: 10.1093/ndt/gft022.


CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats.

Reisman SA, Ward KW, Klaassen CD, Meyer CJ.

Xenobiotica. 2013 Jul;43(7):571-8. doi: 10.3109/00498254.2012.750022.


Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney.

An WS, Kim HJ, Cho KH, Vaziri ND.

Am J Physiol Renal Physiol. 2009 Oct;297(4):F895-903. doi: 10.1152/ajprenal.00217.2009.


Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.

Lau WL, Liu SM, Pahlevan S, Yuan J, Khazaeli M, Ni Z, Chan JY, Vaziri ND.

Dig Dis Sci. 2015 May;60(5):1215-22. doi: 10.1007/s10620-014-3428-4.


Triterpenoid dihydro-CDDO-trifluoroethyl amide protects against maladaptive cardiac remodeling and dysfunction in mice: a critical role of Nrf2.

Xing Y, Niu T, Wang W, Li J, Li S, Janicki JS, Ruiz S, Meyer CJ, Wang XL, Tang D, Zhao Y, Cui T.

PLoS One. 2012;7(9):e44899. doi: 10.1371/journal.pone.0044899.


Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease.

Ruiz S, Pergola PE, Zager RA, Vaziri ND.

Kidney Int. 2013 Jun;83(6):1029-41. doi: 10.1038/ki.2012.439. Review.


Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.

Ichikawa T, Li J, Meyer CJ, Janicki JS, Hannink M, Cui T.

PLoS One. 2009 Dec 21;4(12):e8391. doi: 10.1371/journal.pone.0008391.


The effect of Nrf2 pathway activation on human pancreatic islet cells.

Masuda Y, Vaziri ND, Li S, Le A, Hajighasemi-Ossareh M, Robles L, Foster CE, Stamos MJ, Al-Abodullah I, Ricordi C, Ichii H.

PLoS One. 2015 Jun 25;10(6):e0131012. doi: 10.1371/journal.pone.0131012.


Tanshinone IIA attenuates renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-κB signaling pathway in 5/6 nephrectomized rats.

Wang DT, Huang RH, Cheng X, Zhang ZH, Yang YJ, Lin X.

Int Immunopharmacol. 2015 May;26(1):4-12. doi: 10.1016/j.intimp.2015.02.027.


Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.

Saito H.

Biochem Pharmacol. 2013 Apr 1;85(7):865-72. doi: 10.1016/j.bcp.2013.01.006. Review.


Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.

Li B, Abdalrahman A, Lai Y, Janicki JS, Ward KW, Meyer CJ, Wang XL, Tang D, Cui T.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):555-61. doi: 10.1016/j.bbrc.2014.01.101.


Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling.

Hong YA, Lim JH, Kim MY, Kim EN, Koh ES, Shin SJ, Choi BS, Park CW, Chang YS, Chung S.

J Transl Med. 2014 Feb 21;12:50. doi: 10.1186/1479-5876-12-50.


Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease.

Tan SM, Sharma A, Stefanovic N, Yuen DY, Karagiannis TC, Meyer C, Ward KW, Cooper ME, de Haan JB.

Diabetes. 2014 Sep;63(9):3091-103. doi: 10.2337/db13-1743.


Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD.

J Pharmacol Exp Ther. 2010 Oct;335(1):2-12. doi: 10.1124/jpet.110.170084.


Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.

Probst BL, McCauley L, Trevino I, Wigley WC, Ferguson DA.

PLoS One. 2015 Aug 24;10(8):e0135257. doi: 10.1371/journal.pone.0135257.

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