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The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation.

Bause AS, Matsui MS, Haigis MC.

J Biol Chem. 2013 Dec 20;288(51):36484-91. doi: 10.1074/jbc.M113.472324. Epub 2013 Nov 5.


STRESS-responsive deacetylase SIRT3 is up-regulated by areca nut extract-induced oxidative stress in human oral keratinocytes.

Chen IC, Chiang WF, Chen PF, Chiang HC.

J Cell Biochem. 2014 Feb;115(2):328-39. doi: 10.1002/jcb.24667.


SIRT3, a mitochondrial NAD⁺-dependent deacetylase, is involved in the regulation of myoblast differentiation.

Abdel Khalek W, Cortade F, Ollendorff V, Lapasset L, Tintignac L, Chabi B, Wrutniak-Cabello C.

PLoS One. 2014 Dec 9;9(12):e114388. doi: 10.1371/journal.pone.0114388. eCollection 2014.


Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function.

Ding Y, Yang H, Wang Y, Chen J, Ji Z, Sun H.

Int J Biol Sci. 2017 Feb 12;13(2):254-264. doi: 10.7150/ijbs.17053. eCollection 2017.


Sirt3 attenuates hydrogen peroxide-induced oxidative stress through the preservation of mitochondrial function in HT22 cells.

Dai SH, Chen T, Wang YH, Zhu J, Luo P, Rao W, Yang YF, Fei Z, Jiang XF.

Int J Mol Med. 2014 Oct;34(4):1159-68. doi: 10.3892/ijmm.2014.1876. Epub 2014 Aug 4.


SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB.

Chen CJ, Fu YC, Yu W, Wang W.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):798-803. doi: 10.1016/j.bbrc.2012.11.066. Epub 2012 Nov 29.


Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes.

Cheung KG, Cole LK, Xiang B, Chen K, Ma X, Myal Y, Hatch GM, Tong Q, Dolinsky VW.

J Biol Chem. 2015 Apr 24;290(17):10981-93. doi: 10.1074/jbc.M114.607960. Epub 2015 Mar 10.


Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis.

Dai SH, Chen T, Wang YH, Zhu J, Luo P, Rao W, Yang YF, Fei Z, Jiang XF.

Int J Mol Sci. 2014 Aug 21;15(8):14591-609. doi: 10.3390/ijms150814591.


Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes.

Zhang L, Han L, Ma R, Hou X, Yu Y, Sun S, Xu Y, Schedl T, Moley KH, Wang Q.

Cell Cycle. 2015;14(18):2959-68. doi: 10.1080/15384101.2015.1026517. Epub 2015 Mar 19.


Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis.

Sosulski ML, Gongora R, Feghali-Bostwick C, Lasky JA, Sanchez CG.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):595-602. doi: 10.1093/gerona/glw151.


SIRT3 mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts.

Xie X, Wang L, Zhao B, Chen Y, Li J.

Life Sci. 2017 May 15;177:41-48. doi: 10.1016/j.lfs.2017.01.010. Epub 2017 Jan 26.


Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway.

Padmaja Divya S, Pratheeshkumar P, Son YO, Vinod Roy R, Andrew Hitron J, Kim D, Dai J, Wang L, Asha P, Huang B, Xu M, Luo J, Zhang Z.

Toxicol Sci. 2015 Aug;146(2):290-300. doi: 10.1093/toxsci/kfv089. Epub 2015 May 15.


Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.

Rangarajan P, Karthikeyan A, Lu J, Ling EA, Dheen ST.

Neuroscience. 2015 Dec 17;311:398-414. doi: 10.1016/j.neuroscience.2015.10.048. Epub 2015 Oct 30.


Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.

Chen IC, Chiang WF, Liu SY, Chen PF, Chiang HC.

Mol Cancer. 2013 Jun 23;12:68. doi: 10.1186/1476-4598-12-68.


Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model.

Zeng L, Yang Y, Hu Y, Sun Y, Du Z, Xie Z, Zhou T, Kong W.

PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e98726.


Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.

Qiu X, Brown K, Hirschey MD, Verdin E, Chen D.

Cell Metab. 2010 Dec 1;12(6):662-7. doi: 10.1016/j.cmet.2010.11.015.


SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin.

Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Zhang R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z.

Autophagy. 2015;11(7):1037-51. doi: 10.1080/15548627.2015.1052208.


Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.

Wu YT, Lee HC, Liao CC, Wei YH.

Biochim Biophys Acta. 2013 Jan;1832(1):216-27. doi: 10.1016/j.bbadis.2012.10.002. Epub 2012 Oct 6.


Sirtuin 4 identification in normal human epidermal keratinocytes and its relation to sirtuin 3 and energy metabolism under normal conditions and UVB-induced stress.

Dong K, Pelle E, Yarosh DB, Pernodet N.

Exp Dermatol. 2012 Mar;21(3):231-3. doi: 10.1111/j.1600-0625.2011.01439.x.


SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.

Koyama T, Kume S, Koya D, Araki S, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H, Uzu T.

Free Radic Biol Med. 2011 Sep 15;51(6):1258-67. doi: 10.1016/j.freeradbiomed.2011.05.028. Epub 2011 May 30.


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