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Items: 1 to 20 of 108

1.

Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells.

Ashour AA, Abdel-Aziz AA, Mansour AM, Alpay SN, Huo L, Ozpolat B.

Apoptosis. 2014 Jan;19(1):241-58. doi: 10.1007/s10495-013-0927-2.

PMID:
24193916
2.

Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion.

Ashour AA, Gurbuz N, Alpay SN, Abdel-Aziz AA, Mansour AM, Huo L, Ozpolat B.

J Cell Mol Med. 2014 Nov;18(11):2235-51. doi: 10.1111/jcmm.12361. Epub 2014 Sep 12.

3.

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells.

Singh BN, Kumar D, Shankar S, Srivastava RK.

Biochem Pharmacol. 2012 Nov 1;84(9):1154-63. doi: 10.1016/j.bcp.2012.08.007. Epub 2012 Aug 15.

PMID:
22902833
4.

Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer.

Tekedereli I, Alpay SN, Tavares CD, Cobanoglu ZE, Kaoud TS, Sahin I, Sood AK, Lopez-Berestein G, Dalby KN, Ozpolat B.

PLoS One. 2012;7(7):e41171. doi: 10.1371/journal.pone.0041171. Epub 2012 Jul 20.

6.

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression.

Zhang Y, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM.

Biochem Biophys Res Commun. 2011 Oct 14;414(1):129-34. doi: 10.1016/j.bbrc.2011.09.038. Epub 2011 Sep 16.

7.

Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact.

Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN.

Biochemistry. 2012 Mar 13;51(10):2100-12. doi: 10.1021/bi201787p. Epub 2012 Mar 5.

8.

Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase.

Cho SI, Koketsu M, Ishihara H, Matsushita M, Nairn AC, Fukazawa H, Uehara Y.

Biochim Biophys Acta. 2000 Jul 26;1475(3):207-15.

PMID:
10913818
9.

Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.

Huber-Keener KJ, Evans BR, Ren X, Cheng Y, Zhang Y, Hait WN, Yang JM.

Biochem Biophys Res Commun. 2012 Jul 27;424(2):308-14. doi: 10.1016/j.bbrc.2012.06.112. Epub 2012 Jun 27.

10.

Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.

Lim JH, Park JW, Choi KS, Park YB, Kwon TK.

Carcinogenesis. 2009 May;30(5):729-36. doi: 10.1093/carcin/bgn265. Epub 2008 Nov 26.

PMID:
19037087
11.

The molecular mechanism of eukaryotic elongation factor 2 kinase activation.

Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN.

J Biol Chem. 2014 Aug 22;289(34):23901-16. doi: 10.1074/jbc.M114.577148. Epub 2014 Jul 10.

12.

Tissue transglutaminase inhibits autophagy in pancreatic cancer cells.

Akar U, Ozpolat B, Mehta K, Fok J, Kondo Y, Lopez-Berestein G.

Mol Cancer Res. 2007 Mar;5(3):241-9.

13.

Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis.

Song KS, Kim JS, Yun EJ, Kim YR, Seo KS, Park JH, Jung YJ, Park JI, Kweon GR, Yoon WH, Lim K, Hwang BD.

Autophagy. 2008 Jul;4(5):650-8. Epub 2008 Apr 7.

PMID:
18424913
14.

A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.

Boyce M, Py BF, Ryazanov AG, Minden JS, Long K, Ma D, Yuan J.

Cell Death Differ. 2008 Mar;15(3):589-99. doi: 10.1038/sj.cdd.4402296. Epub 2008 Jan 11.

15.

Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.

Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN.

Protein Expr Purif. 2011 Oct;79(2):237-44. doi: 10.1016/j.pep.2011.05.005. Epub 2011 May 14. Erratum in: Protein Expr Purif. 2012 Oct;85(2):250.

16.

Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy.

Wu H, Zhu H, Liu DX, Niu TK, Ren X, Patel R, Hait WN, Yang JM.

Cancer Res. 2009 Mar 15;69(6):2453-60. doi: 10.1158/0008-5472.CAN-08-2872. Epub 2009 Feb 24.

17.

Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11.

Dao P, Smith N, Scott-Algara D, Garbay C, Herbeuval JP, Chen H.

Cancer Lett. 2015 Apr 28;360(1):48-59. doi: 10.1016/j.canlet.2015.02.016. Epub 2015 Feb 12.

PMID:
25684663
18.

A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses.

Py BF, Boyce M, Yuan J.

Autophagy. 2009 Apr;5(3):393-6. Epub 2009 Apr 6.

19.

Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.

Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN.

J Biol Chem. 2017 Feb 3;292(5):2032-2045. doi: 10.1074/jbc.M116.753277. Epub 2016 Dec 12.

PMID:
27956550
20.

Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.

Diggle TA, Subkhankulova T, Lilley KS, Shikotra N, Willis AE, Redpath NT.

Biochem J. 2001 Feb 1;353(Pt 3):621-6.

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