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Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study.

Haahr ME, Fisher PM, Jensen CG, Frokjaer VG, Mahon BM, Madsen K, Baaré WF, Lehel S, Norremolle A, Rabiner EA, Knudsen GM.

Mol Psychiatry. 2014 Apr;19(4):427-32. doi: 10.1038/mp.2013.147. Epub 2013 Nov 5.


5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [(11)C]SB207145 PET in humans.

Fisher PM, Holst KK, Mc Mahon B, Haahr ME, Madsen K, Gillings N, Baaré WF, Jensen PS, Knudsen GM.

Neuroimage. 2012 Aug 1;62(1):130-6. doi: 10.1016/j.neuroimage.2012.05.013. Epub 2012 May 11.


High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding.

da Cunha-Bang S, Mc Mahon B, Fisher PM, Jensen PS, Svarer C, Knudsen GM.

Soc Cogn Affect Neurosci. 2016 Apr;11(4):548-55. doi: 10.1093/scan/nsv140. Epub 2016 Jan 15.


Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET.

Marner L, Gillings N, Madsen K, Erritzoe D, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM.

Neuroimage. 2010 Apr 15;50(3):855-61. doi: 10.1016/j.neuroimage.2010.01.054. Epub 2010 Jan 22.


Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels.

Jennings KA, Licht CL, Bruce A, Lesch KP, Knudsen GM, Sharp T.

Int J Neuropsychopharmacol. 2012 Sep;15(8):1099-107. doi: 10.1017/S1461145711001258. Epub 2011 Aug 16.


Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo.

Marner L, Gillings N, Comley RA, Baaré WF, Rabiner EA, Wilson AA, Houle S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM.

J Nucl Med. 2009 Jun;50(6):900-8. doi: 10.2967/jnumed.108.058552.


Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig.

Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knudsen GM.

J Cereb Blood Flow Metab. 2009 Jan;29(1):186-96. doi: 10.1038/jcbfm.2008.110. Epub 2008 Sep 17.


Fluctuations in [¹¹C]SB207145 PET binding associated with change in threat-related amygdala reactivity in humans.

Fisher PM, Haahr ME, Jensen CG, Frokjaer VG, Siebner HR, Knudsen GM.

Neuropsychopharmacology. 2015 May;40(6):1510-8. doi: 10.1038/npp.2014.339. Epub 2015 Jan 6.


Brain serotonin 4 receptor binding is associated with the cortisol awakening response.

Jakobsen GR, Fisher PM, Dyssegaard A, McMahon B, Holst KK, Lehel S, Svarer C, Jensen PS, Knudsen GM, Frokjaer VG.

Psychoneuroendocrinology. 2016 May;67:124-32. doi: 10.1016/j.psyneuen.2016.01.032. Epub 2016 Feb 11.


Familial risk for major depression is associated with lower striatal 5-HT₄ receptor binding.

Madsen K, Torstensen E, Holst KK, Haahr ME, Knorr U, Frokjaer VG, Brandt-Larsen M, Iversen P, Fisher PM, Knudsen GM.

Int J Neuropsychopharmacol. 2014 Oct 31;18(1). pii: pyu034. doi: 10.1093/ijnp/pyu034.


Brain serotonin 4 receptor binding is inversely associated with verbal memory recall.

Stenbæk DS, Fisher PM, Ozenne B, Andersen E, Hjordt LV, McMahon B, Hasselbalch SG, Frokjaer VG, Knudsen GM.

Brain Behav. 2017 Mar 17;7(4):e00674. doi: 10.1002/brb3.674. eCollection 2017 Apr.


Age and sex effects on 5-HT(4) receptors in the human brain: a [(11)C]SB207145 PET study.

Madsen K, Haahr MT, Marner L, Keller SH, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM.

J Cereb Blood Flow Metab. 2011 Jun;31(6):1475-81. doi: 10.1038/jcbfm.2011.11. Epub 2011 Mar 2.


Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a single oral dose of fluoxetine: a positron-emission tomography study in healthy volunteers.

Sibon I, Benkelfat C, Gravel P, Aznavour N, Costes N, Mzengeza S, Booij L, Baker G, Soucy JP, Zimmer L, Descarries L.

Biol Psychiatry. 2008 Jun 15;63(12):1135-40. doi: 10.1016/j.biopsych.2007.11.016. Epub 2008 Jan 14.


Mass dose effects and in vivo affinity in brain PET receptor studies--a study of cerebral 5-HT4 receptor binding with [11C]SB207145.

Madsen K, Marner L, Haahr M, Gillings N, Knudsen GM.

Nucl Med Biol. 2011 Nov;38(8):1085-91. doi: 10.1016/j.nucmedbio.2011.04.006. Epub 2011 Aug 9.


Testosterone levels in healthy men correlate negatively with serotonin 4 receptor binding.

Perfalk E, Cunha-Bang SD, Holst KK, Keller S, Svarer C, Knudsen GM, Frokjaer VG.

Psychoneuroendocrinology. 2017 Jul;81:22-28. doi: 10.1016/j.psyneuen.2017.03.018. Epub 2017 Mar 22.


Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus.

Imoto Y, Kira T, Sukeno M, Nishitani N, Nagayasu K, Nakagawa T, Kaneko S, Kobayashi K, Segi-Nishida E.

Mol Brain. 2015 May 15;8:29. doi: 10.1186/s13041-015-0120-3.


The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.

Licht CL, Marcussen AB, Wegener G, Overstreet DH, Aznar S, Knudsen GM.

J Neurochem. 2009 Jun;109(5):1363-74. doi: 10.1111/j.1471-4159.2009.06050.x. Epub 2009 Mar 23.


Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's disease.

Madsen K, Neumann WJ, Holst K, Marner L, Haahr MT, Lehel S, Knudsen GM, Hasselbalch SG.

J Alzheimers Dis. 2011;26(3):457-66. doi: 10.3233/JAD-2011-110056.


Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone.

Talbot PS, Slifstein M, Hwang DR, Huang Y, Scher E, Abi-Dargham A, Laruelle M.

Neuroimage. 2012 Jan 2;59(1):271-85. doi: 10.1016/j.neuroimage.2011.07.001. Epub 2011 Jul 18.


The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans.

Haahr ME, Fisher P, Holst K, Madsen K, Jensen CG, Marner L, Lehel S, Baaré W, Knudsen G, Hasselbalch S.

Hum Brain Mapp. 2013 Nov;34(11):3066-74. doi: 10.1002/hbm.22123. Epub 2012 Jun 26.


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