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Items: 1 to 20 of 121


Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth.

Pedroni SM, Gonzalez JM, Wade J, Jansen MA, Serio A, Marshall I, Lennen RJ, Girardi G.

Biochim Biophys Acta. 2014 Jan;1842(1):107-15. doi: 10.1016/j.bbadis.2013.10.011. Epub 2013 Oct 30.


Statins prevent cervical remodeling, myometrial contractions and preterm labor through a mechanism that involves hemoxygenase-1 and complement inhibition.

Gonzalez JM, Pedroni SM, Girardi G.

Mol Hum Reprod. 2014 Jun;20(6):579-89. doi: 10.1093/molehr/gau019. Epub 2014 Mar 12.


IL-1 receptor blockade prevents fetal cortical brain injury but not preterm birth in a mouse model of inflammation-induced preterm birth and perinatal brain injury.

Leitner K, Al Shammary M, McLane M, Johnston MV, Elovitz MA, Burd I.

Am J Reprod Immunol. 2014 May;71(5):418-26. doi: 10.1111/aji.12216. Epub 2014 Mar 5.


Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo.

Mukherjee P, Thomas S, Pasinetti GM.

J Neuroinflammation. 2008 Jan 29;5:5. doi: 10.1186/1742-2094-5-5.


IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway.

Gong B, Pan Y, Zhao W, Knable L, Vempati P, Begum S, Ho L, Wang J, Yemul S, Barnum S, Bilski A, Gong BY, Pasinetti GM.

Mol Immunol. 2013 Dec;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.


Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease.

Farkas I, Takahashi M, Fukuda A, Yamamoto N, Akatsu H, Baranyi L, Tateyama H, Yamamoto T, Okada N, Okada H.

J Immunol. 2003 Jun 1;170(11):5764-71.


Complement inhibition keeps mothers calm and avoids fetal rejection.

Girardi G.

Immunol Invest. 2008;37(5):645-59. doi: 10.1080/08820130802191615. Review.


Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.

McDonald CR, Cahill LS, Ho KT, Yang J, Kim H, Silver KL, Ward PA, Mount HT, Liles WC, Sled JG, Kain KC.

PLoS Pathog. 2015 Sep 24;11(9):e1005140. doi: 10.1371/journal.ppat.1005140. eCollection 2015 Sep.


Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model.

Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L.

Autoimmunity. 2015;48(7):460-70. doi: 10.3109/08916934.2015.1031888. Epub 2015 Apr 27.


Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice.

Gonzalez JM, Franzke CW, Yang F, Romero R, Girardi G.

Am J Pathol. 2011 Aug;179(2):838-49. doi: 10.1016/j.ajpath.2011.04.024. Epub 2011 Jun 12.


Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis.

Chen G, Yang Y, Gao X, Dou Y, Wang H, Han G, Wang R, Wang J, Wang L, Li X, Guo R, Xiao H, Shen B, Li Y.

Lab Invest. 2011 Mar;91(3):472-83. doi: 10.1038/labinvest.2010.183. Epub 2010 Nov 22.


Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis.

Lalli PN, Strainic MG, Yang M, Lin F, Medof ME, Heeger PS.

Blood. 2008 Sep 1;112(5):1759-66. doi: 10.1182/blood-2008-04-151068. Epub 2008 Jun 20.


Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome.

Bertolaccini ML, Contento G, Lennen R, Sanna G, Blower PJ, Ma MT, Sunassee K, Girardi G.

J Autoimmun. 2016 Dec;75:30-38. doi: 10.1016/j.jaut.2016.04.008. Epub 2016 May 6.


Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis.

Pavlovski D, Thundyil J, Monk PN, Wetsel RA, Taylor SM, Woodruff TM.

FASEB J. 2012 Sep;26(9):3680-90. doi: 10.1096/fj.11-202382. Epub 2012 May 31.


C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression.

Xu GL, Chen J, Yang F, Li GQ, Zheng LX, Wu YZ.

Hepatology. 2014 Jul;60(1):114-24. doi: 10.1002/hep.27114. Epub 2014 May 28.


Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.

Osaka H, McGinty A, Höepken UE, Lu B, Gerard C, Pasinetti GM.

Neuroscience. 1999;88(4):1073-82.


The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model.

Liang DY, Li X, Shi X, Sun Y, Sahbaie P, Li WW, Clark JD.

Pain. 2012 Feb;153(2):366-72. doi: 10.1016/j.pain.2011.10.032. Epub 2011 Dec 1.

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