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CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.

Ellis BC, Graham LD, Molloy PL.

Biochim Biophys Acta. 2014 Feb;1843(2):372-86. doi: 10.1016/j.bbamcr.2013.10.016. Epub 2013 Nov 1.


CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling.

Wang Y, Wang Y, Li J, Zhang Y, Yin H, Han B.

Cancer Lett. 2015 Oct 28;367(2):122-8. doi: 10.1016/j.canlet.2015.03.027. Epub 2015 Mar 23.


The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling.

Han P, Li JW, Zhang BM, Lv JC, Li YM, Gu XY, Yu ZW, Jia YH, Bai XF, Li L, Liu YL, Cui BB.

Mol Cancer. 2017 Jan 13;16(1):9. doi: 10.1186/s12943-017-0583-1.


The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway.

Yu B, Ye X, Du Q, Zhu B, Zhai Q, Li XX.

Cell Physiol Biochem. 2017;41(6):2489-2502. doi: 10.1159/000475941. Epub 2017 May 4.


CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186.

Zheng J, Li XD, Wang P, Liu XB, Xue YX, Hu Y, Li Z, Li ZQ, Wang ZH, Liu YH.

Oncotarget. 2015 Sep 22;6(28):25339-55. doi: 10.18632/oncotarget.4509.


Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells.

Jiao S, Ren H, Li Y, Zhou J, Duan C, Lu L.

Mol Cell Biochem. 2013 Jan;373(1-2):107-13. doi: 10.1007/s11010-012-1479-4. Epub 2012 Oct 10.


IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway.

Matà R, Palladino C, Nicolosi ML, Lo Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A.

Oncotarget. 2016 Feb 16;7(7):7683-700. doi: 10.18632/oncotarget.6524.


Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells.

Chang LH, Chen CH, Huang DY, Pai HC, Pan SL, Teng CM.

J Cell Physiol. 2011 Apr;226(4):1060-8. doi: 10.1002/jcp.22428.


Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.

Makinoshima H, Takita M, Saruwatari K, Umemura S, Obata Y, Ishii G, Matsumoto S, Sugiyama E, Ochiai A, Abe R, Goto K, Esumi H, Tsuchihara K.

J Biol Chem. 2015 Jul 10;290(28):17495-504. doi: 10.1074/jbc.M115.660498. Epub 2015 May 28.


Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells.

Yi HK, Kim SY, Hwang PH, Kim CY, Yang DH, Oh Y, Lee DY.

Biochem Biophys Res Commun. 2005 May 13;330(3):760-7.


Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells.

Lau MT, So WK, Leung PC.

PLoS One. 2013;8(3):e59083. doi: 10.1371/journal.pone.0059083. Epub 2013 Mar 15.


The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer.

Wen X, Zhu J, Dong L, Chen Y.

Med Oncol. 2014 Aug;31(8):92. doi: 10.1007/s12032-014-0092-7. Epub 2014 Jul 15.


GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.

Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C, Wei Y.

Carcinogenesis. 2013 Dec;34(12):2861-9. doi: 10.1093/carcin/bgt229. Epub 2013 Jun 26.


Long Noncoding RNA CRNDE Promotes Proliferation of Gastric Cancer Cells by Targeting miR-145.

Hu CE, Du PZ, Zhang HD, Huang GJ.

Cell Physiol Biochem. 2017;42(1):13-21. doi: 10.1159/000477107. Epub 2017 May 10.


Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway.

Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD, Glass DJ.

J Biol Chem. 2005 Jan 28;280(4):2737-44. Epub 2004 Nov 17.


Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.

Xiong W, Jiang YX, Ai YQ, Liu S, Wu XR, Cui JG, Qin JY, Liu Y, Xia YX, Ju YH, He WJ, Wang Y, Li YF, Hou Y, Wang L, Li WH.

Asian Pac J Cancer Prev. 2015;16(8):3395-402.

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