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Items: 1 to 20 of 127

1.

The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors.

Xin M, Wen J, Tang F, Tu C, Shen H, Zhao X.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6777-83. doi: 10.1016/j.bmcl.2013.10.022. Epub 2013 Oct 17.

PMID:
24176396
2.

Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors.

Xin M, Zhang L, Wen J, Shen H, Liu Z, Zhao X, Jin Q, Wang M, Cheng L, Huang W, Tang F.

Bioorg Med Chem. 2016 Mar 1;24(5):1079-88. doi: 10.1016/j.bmc.2016.01.034. Epub 2016 Jan 19.

PMID:
26827136
3.

Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway.

Xin M, Wen J, Tang F, Tu C, Huang W, Shen H, Zhao X, Cheng L, Wang M, Zhang L.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):983-8. doi: 10.1016/j.bmcl.2013.12.050. Epub 2013 Dec 17.

PMID:
24405704
4.

Introduction of fluorine to phenyl group of 4-(2-pyrimidinylamino)benzamides leading to a series of potent hedgehog signaling pathway inhibitors.

Xin M, Zhang L, Wen J, Shen H, Zhao X, Jin Q, Tang F.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3259-3263. doi: 10.1016/j.bmcl.2017.06.030. Epub 2017 Jun 13.

PMID:
28642101
5.

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors.

Xin M, Zhang L, Tang F, Tu C, Wen J, Zhao X, Liu Z, Cheng L, Shen H.

Bioorg Med Chem. 2014 Feb 15;22(4):1429-40. doi: 10.1016/j.bmc.2013.12.055. Epub 2014 Jan 3.

PMID:
24486203
6.

Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors.

Xin M, Zhang L, Jin Q, Tang F, Wen J, Gu L, Cheng L, Zhao Y.

Eur J Med Chem. 2016 Mar 3;110:115-25. doi: 10.1016/j.ejmech.2016.01.018. Epub 2016 Jan 20.

PMID:
26820554
7.

Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and hedgehog signaling pathway inhibition study.

Zhang L, Xin M, Shen H, Wen J, Tang F, Tu C, Zhao X, Wei P.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3486-92. doi: 10.1016/j.bmcl.2014.05.066. Epub 2014 May 28.

PMID:
24923765
8.

Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.

Li Y, Zhou Y, Qian P, Wang Y, Jiang F, Yao Z, Hu W, Zhao Y, Li S.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):179-82. doi: 10.1016/j.bmcl.2012.10.114. Epub 2012 Nov 5.

PMID:
23206867
9.

Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists.

Wu TM, Wang DC, Xiang P, Zhang JN, Sang YX, Lin HJ, Chen J, Xie G, Song H, Zhao YL, Xie YM.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1426-31. doi: 10.1016/j.bmcl.2014.01.006. Epub 2014 Jan 15.

PMID:
24491459
10.

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

Burns CJ, Bourke DG, Andrau L, Bu X, Charman SA, Donohue AC, Fantino E, Farrugia M, Feutrill JT, Joffe M, Kling MR, Kurek M, Nero TL, Nguyen T, Palmer JT, Phillips I, Shackleford DM, Sikanyika H, Styles M, Su S, Treutlein H, Zeng J, Wilks AF.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92. doi: 10.1016/j.bmcl.2009.08.071. Epub 2009 Aug 23.

PMID:
19762238
11.

Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer.

Zhang CH, Zheng MW, Li YP, Lin XD, Huang M, Zhong L, Li GB, Zhang RJ, Lin WT, Jiao Y, Wu XA, Yang J, Xiang R, Chen LJ, Zhao YL, Cheng W, Wei YQ, Yang SY.

J Med Chem. 2015 May 14;58(9):3957-74. doi: 10.1021/acs.jmedchem.5b00270. Epub 2015 Apr 16.

PMID:
25835317
12.

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

B├╝ttner A, Seifert K, Cottin T, Sarli V, Tzagkaroulaki L, Scholz S, Giannis A.

Bioorg Med Chem. 2009 Jul 15;17(14):4943-54. doi: 10.1016/j.bmc.2009.06.008. Epub 2009 Jun 10.

PMID:
19541490
13.

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist.

Chen X, Pierce B, Naing W, Grapperhaus ML, Phillion DP.

Bioorg Med Chem Lett. 2010 May 15;20(10):3107-11. doi: 10.1016/j.bmcl.2010.03.094. Epub 2010 Mar 30.

PMID:
20392639
14.

Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.

Lu X, Peng Y, Wang C, Yang J, Bao X, Dong Q, Zhao W, Tan W, Dong X.

Eur J Med Chem. 2017 Sep 29;138:384-395. doi: 10.1016/j.ejmech.2017.06.031. Epub 2017 Jun 21.

PMID:
28688278
15.

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.

Ohashi T, Tanaka Y, Shiokawa Z, Banno H, Tanaka T, Shibata S, Satoh Y, Yamakawa H, Yamamoto Y, Hattori H, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S.

Bioorg Med Chem. 2015 Aug 1;23(15):4777-91. doi: 10.1016/j.bmc.2015.05.036. Epub 2015 Jun 3.

PMID:
26094943
16.

Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme.

Chen L, Li H, Liu J, Zhang L, Liu H, Jiang H.

Bioorg Med Chem. 2007 Nov 1;15(21):6763-74. Epub 2007 Aug 10.

PMID:
17719791
17.

Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.

Takayama H, Jia ZJ, Kremer L, Bauer JO, Strohmann C, Ziegler S, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12404-8. doi: 10.1002/anie.201306948. Epub 2013 Oct 2.

PMID:
24115579
18.

Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors.

Chen Z, Venkatesan AM, Dehnhardt CM, Ayral-Kaloustian S, Brooijmans N, Mallon R, Feldberg L, Hollander I, Lucas J, Yu K, Kong F, Mansour TS.

J Med Chem. 2010 Apr 22;53(8):3169-82. doi: 10.1021/jm901783v.

PMID:
20334367
19.

Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors.

Bhattarai D, Jung JH, Han S, Lee H, Oh SJ, Ko HW, Lee K.

Eur J Med Chem. 2017 Jan 5;125:1036-1050. doi: 10.1016/j.ejmech.2016.10.040. Epub 2016 Oct 19.

PMID:
27810591
20.

Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.

Chenna V, Hu C, Khan SR.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2014;49(6):641-7. doi: 10.1080/10934529.2014.865425.

PMID:
24521409

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