Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 77

1.

Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.

Pandit B, Hu Z, Chettiar SN, Zink J, Xiao Z, Etter JP, Bhasin D, Li PK.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6902-4. doi: 10.1016/j.bmcl.2013.09.084. Epub 2013 Oct 4.

PMID:
24169233
2.

Novel tubulin-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells: possible anti-myeloma mechanism of thalidomide.

Iguchi T, Yachide-Noguchi T, Hashimoto Y, Nakazato S, Sagawa M, Ikeda Y, Kizaki M.

Int J Mol Med. 2008 Feb;21(2):163-8.

PMID:
18204782
3.

A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities.

Li PK, Pandit B, Sackett DL, Hu Z, Zink J, Zhi J, Freeman D, Robey RW, Werbovetz K, Lewis A, Li C.

Mol Cancer Ther. 2006 Feb;5(2):450-6.

4.

Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin.

Rashid A, Kuppa A, Kunwar A, Panda D.

Biochemistry. 2015 Mar 31;54(12):2149-59. doi: 10.1021/bi501429j. Epub 2015 Mar 17.

PMID:
25747795
5.

Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures.

Chen XX, Gao F, Wang Q, Huang X, Wang D.

Fitoterapia. 2014 Jan;92:111-5. doi: 10.1016/j.fitote.2013.10.015. Epub 2013 Nov 6.

PMID:
24211350
6.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.

Paterson I, Naylor GJ, Fujita T, Guzmán E, Wright AE.

Chem Commun (Camb). 2010 Jan 14;46(2):261-3. doi: 10.1039/b921237j. Epub 2009 Nov 24.

PMID:
20024345
7.

Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents.

Yang J, Zhou S, Ji L, Zhang C, Yu S, Li Z, Meng X.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5055-8. doi: 10.1016/j.bmcl.2014.09.016. Epub 2014 Sep 16.

PMID:
25278233
8.
9.

New tubulin polymerization inhibitor derived from thalidomide: implications for anti-myeloma therapy.

Kizaki M, Hashimoto Y.

Curr Med Chem. 2008;15(8):754-65. Review.

PMID:
18393844
10.

Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.

Yamazaki Y, Sumikura M, Masuda Y, Hayashi Y, Yasui H, Kiso Y, Chinen T, Usui T, Yakushiji F, Potts B, Neuteboom S, Palladino M, Lloyd GK, Hayashi Y.

Bioorg Med Chem. 2012 Jul 15;20(14):4279-89. doi: 10.1016/j.bmc.2012.05.059. Epub 2012 Jun 4.

PMID:
22727370
11.

Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.

Pfeiffer B, Hauenstein K, Merz P, Gertsch J, Altmann KH.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3760-3. doi: 10.1016/j.bmcl.2009.04.112. Epub 2009 May 3.

PMID:
19433359
12.

Cell differentiation inducers derived from thalidomide.

Noguchi T, Miyachi H, Katayama R, Naito M, Hashimoto Y.

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3212-5.

PMID:
15936192
13.

The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.

Martello LA, LaMarche MJ, He L, Beauchamp TJ, Smith AB, Horwitz SB.

Chem Biol. 2001 Sep;8(9):843-55.

14.

Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.

Zheng CH, Chen J, Liu J, Zhou XT, Liu N, Shi D, Huang JJ, Lv JG, Zhu J, Zhou YJ.

Arch Pharm (Weinheim). 2012 Jun;345(6):454-62. doi: 10.1002/ardp.201100169. Epub 2012 Mar 13.

PMID:
22415658
15.

Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis.

Solum EJ, Cheng JJ, Sørvik IB, Paulsen RE, Vik A, Hansen TV.

Eur J Med Chem. 2014 Oct 6;85:391-8. doi: 10.1016/j.ejmech.2014.08.002. Epub 2014 Aug 2.

PMID:
25108078
16.

Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH group.

Sharma S, Lagisetti C, Poliks B, Coates RM, Kingston DG, Bane S.

Biochemistry. 2013 Apr 2;52(13):2328-36. doi: 10.1021/bi400014t. Epub 2013 Mar 19.

17.

1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.

Odlo K, Fournier-Dit-Chabert J, Ducki S, Gani OA, Sylte I, Hansen TV.

Bioorg Med Chem. 2010 Sep 15;18(18):6874-85. doi: 10.1016/j.bmc.2010.07.032. Epub 2010 Jul 17.

PMID:
20708408
18.

Synthesis of anti-microtubule N-(2-Arylindol-7-yl)benzenesulfonamide derivatives and their antitumor mechanisms.

Chiou CT, Chen GS, Chen ML, Li H, Shi L, Huang XH, Dai WM, Chern JW.

ChemMedChem. 2010 Sep 3;5(9):1489-97. doi: 10.1002/cmdc.201000228. No abstract available.

PMID:
20672297
19.

Discovery of CYT997: a structurally novel orally active microtubule targeting agent.

Burns CJ, Harte MF, Bu X, Fantino E, Joffe M, Sikanyika H, Su S, Tranberg CE, Wilson N, Charman SA, Shackleford DM, Wilks AF.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4639-42. doi: 10.1016/j.bmcl.2009.06.079. Epub 2009 Jun 25.

PMID:
19616947
20.

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.

Canales A, Rodríguez-Salarichs J, Trigili C, Nieto L, Coderch C, Andreu JM, Paterson I, Jiménez-Barbero J, Díaz JF.

ACS Chem Biol. 2011 Aug 19;6(8):789-99. doi: 10.1021/cb200099u. Epub 2011 May 13.

PMID:
21539341

Supplemental Content

Support Center