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CK8 phosphorylation induced by compressive loads underlies the downregulation of CK8 in human disc degeneration by activating protein kinase C.

Sun Z, Guo YS, Yan SJ, Wan ZY, Gao B, Wang L, Liu ZH, Gao Y, Samartzis D, Lan LF, Wang HQ, Luo ZJ.

Lab Invest. 2013 Dec;93(12):1323-30. doi: 10.1038/labinvest.2013.122. Epub 2013 Oct 28.


Down-regulated CK8 expression in human intervertebral disc degeneration.

Sun Z, Wang HQ, Liu ZH, Chang L, Chen YF, Zhang YZ, Zhang WL, Gao Y, Wan ZY, Che L, Liu X, Samartzis D, Luo ZJ.

Int J Med Sci. 2013 Jun 8;10(8):948-56. doi: 10.7150/ijms.5642. Print 2013.


Alterations of ADAMTSs and TIMP-3 in human nucleus pulposus cells subjected to compressive load: Implications in the pathogenesis of human intervertebral disc degeneration.

Huang M, Wang HQ, Zhang Q, Yan XD, Hao M, Luo ZJ.

J Orthop Res. 2012 Feb;30(2):267-73. doi: 10.1002/jor.21507. Epub 2011 Aug 1.


Adipose-derived stromal cells protect intervertebral disc cells in compression: implications for stem cell regenerative disc therapy.

Sun Z, Luo B, Liu ZH, Samartzis D, Liu Z, Gao B, Huang L, Luo ZJ.

Int J Biol Sci. 2015 Jan 1;11(2):133-43. doi: 10.7150/ijbs.10598. eCollection 2015.


Human intervertebral disc internal strain in compression: the effect of disc region, loading position, and degeneration.

O'Connell GD, Vresilovic EJ, Elliott DM.

J Orthop Res. 2011 Apr;29(4):547-55. doi: 10.1002/jor.21232. Epub 2010 Oct 26.


Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling.

Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, Risbud MV.

J Bone Miner Res. 2007 Dec;22(12):1996-2006.


Increased periostin gene expression in degenerative intervertebral disc cells.

Tsai TT, Lai PL, Liao JC, Fu TS, Niu CC, Chen LH, Lee MS, Chen WJ, Fang HC, Ho NY, Pang JH.

Spine J. 2013 Mar;13(3):289-98. doi: 10.1016/j.spinee.2013.01.040. Epub 2013 Feb 27.


Impact of direct cell co-cultures on human adipose-derived stromal cells and nucleus pulposus cells.

Sun Z, Liu ZH, Zhao XH, Sun L, Chen YF, Zhang WL, Gao Y, Zhang YZ, Wan ZY, Samartzis D, Wang HQ, Luo ZJ.

J Orthop Res. 2013 Nov;31(11):1804-13. doi: 10.1002/jor.22439. Epub 2013 Aug 2.


Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes.

Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA.

Arthritis Res Ther. 2010;12(1):R22. doi: 10.1186/ar2929. Epub 2010 Feb 11.


FasL expression on human nucleus pulposus cells contributes to the immune privilege of intervertebral disc by interacting with immunocytes.

Liu ZH, Sun Z, Wang HQ, Ge J, Jiang TS, Chen YF, Ma Y, Wang C, Hu S, Samartzis D, Luo ZJ.

Int J Med Sci. 2013 Jun 21;10(8):1053-60. doi: 10.7150/ijms.6223. Print 2013.


Role of microRNA-210 in human intervertebral disc degeneration.

Zhang DY, Wang ZJ, Yu YB, Zhang Y, Zhang XX.

Exp Ther Med. 2016 Jun;11(6):2349-2354. Epub 2016 Mar 21.


Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3.

Wang HQ, Yu XD, Liu ZH, Cheng X, Samartzis D, Jia LT, Wu SX, Huang J, Chen J, Luo ZJ.

J Pathol. 2011 Oct;225(2):232-42. doi: 10.1002/path.2931. Epub 2011 Jun 27.


Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration.

Jiang L, Zhang X, Zheng X, Ru A, Ni X, Wu Y, Tian N, Huang Y, Xue E, Wang X, Xu H.

J Orthop Res. 2013 May;31(5):692-702. doi: 10.1002/jor.22289. Epub 2012 Dec 13.


Immune cascades in human intervertebral disc: the pros and cons.

Sun Z, Zhang M, Zhao XH, Liu ZH, Gao Y, Samartzis D, Wang HQ, Luo ZJ.

Int J Clin Exp Pathol. 2013 May 15;6(6):1009-14. Print 2013. Review.


Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.

Zhang Z, Kakutani K, Maeno K, Takada T, Yurube T, Doita M, Kurosaka M, Nishida K.

Arthritis Res Ther. 2011;13(6):R200. doi: 10.1186/ar3533. Epub 2011 Dec 8.


Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration.

Smolders LA, Meij BP, Riemers FM, Licht R, Wubbolts R, Heuvel D, Grinwis GC, Vernooij HC, Hazewinkel HA, Penning LC, Tryfonidou MA.

J Orthop Res. 2012 Jun;30(6):950-7. doi: 10.1002/jor.22000. Epub 2011 Nov 14.


PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

Omary MB, Baxter GT, Chou CF, Riopel CL, Lin WY, Strulovici B.

J Cell Biol. 1992 May;117(3):583-93.


Human anulus fibrosis and nucleus pulposus cells of the intervertebral disc: effect of degeneration and culture system on cell phenotype.

Kluba T, Niemeyer T, Gaissmaier C, Gründer T.

Spine (Phila Pa 1976). 2005 Dec 15;30(24):2743-8.


A new porcine in vivo animal model of disc degeneration: response of anulus fibrosus cells, chondrocyte-like nucleus pulposus cells, and notochordal nucleus pulposus cells to partial nucleotomy.

Omlor GW, Nerlich AG, Wilke HJ, Pfeiffer M, Lorenz H, Schaaf-Keim M, Bertram H, Richter W, Carstens C, Guehring T.

Spine (Phila Pa 1976). 2009 Dec 1;34(25):2730-9. doi: 10.1097/BRS.0b013e3181b723c9.


Fibronectin fragment activation of ERK increasing integrin α₅ and β₁ subunit expression to degenerate nucleus pulposus cells.

Xia M, Zhu Y.

J Orthop Res. 2011 Apr;29(4):556-61. doi: 10.1002/jor.21273. Epub 2010 Nov 9.

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