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FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs.

Yokobori T, Yokoyama Y, Mogi A, Endoh H, Altan B, Kosaka T, Yamaki E, Yajima T, Tomizawa K, Azuma Y, Onozato R, Miyazaki T, Tanaka S, Kuwano H.

Mol Cancer Res. 2014 Jan;12(1):32-7. doi: 10.1158/1541-7786.MCR-13-0341. Epub 2013 Oct 28.


Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients.

Ibusuki M, Yamamoto Y, Shinriki S, Ando Y, Iwase H.

Cancer Sci. 2011 Feb;102(2):439-45. doi: 10.1111/j.1349-7006.2010.01801.x. Epub 2010 Dec 7.


Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance.

Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M.

Int J Cancer. 2010 Apr 15;126(8):1828-37. doi: 10.1002/ijc.24879.


FBW7 upregulation enhances cisplatin cytotoxicity in non- small cell lung cancer cells.

Yu HG, Wei W, Xia LH, Han WL, Zhao P, Wu SJ, Li WD, Chen W.

Asian Pac J Cancer Prev. 2013;14(11):6321-6.


FBXW7 and DNA copy number instability.

Byrd KN, Huey B, Roydasgupta R, Fridlyand J, Snijders AM, Albertson DG.

Breast Cancer Res Treat. 2008 May;109(1):47-54. Epub 2007 Jun 23.


Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway.

Wang X, Zhang J, Zhou L, Sun W, Zheng ZG, Lu P, Gao Y, Yang XS, Zhang ZC, Tao KS, Dou KF.

Int J Oncol. 2015 Jul;47(1):231-43. doi: 10.3892/ijo.2015.2981. Epub 2015 May 4.


The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway.

Eto K, Iwatsuki M, Watanabe M, Ishimoto T, Ida S, Imamura Y, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Baba H.

Int J Cancer. 2015 Apr 1;136(7):1537-45. doi: 10.1002/ijc.29168. Epub 2014 Sep 11.


Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma.

Yokobori T, Mimori K, Iwatsuki M, Ishii H, Tanaka F, Sato T, Toh H, Sudo T, Iwaya T, Tanaka Y, Onoyama I, Kuwano H, Nakayama KI, Mori M.

Int J Oncol. 2012 Jul;41(1):253-9. doi: 10.3892/ijo.2012.1436. Epub 2012 Apr 19.


Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

Fujii Y, Yada M, Nishiyama M, Kamura T, Takahashi H, Tsunematsu R, Susaki E, Nakagawa T, Matsumoto A, Nakayama KI.

Cancer Sci. 2006 Aug;97(8):729-36.


MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7.

Zhou X, Jin W, Jia H, Yan J, Zhang G.

J Exp Clin Cancer Res. 2015 Mar 26;34:28. doi: 10.1186/s13046-015-0145-6.


MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer.

Calcagno DQ, Freitas VM, Leal MF, de Souza CR, Demachki S, Montenegro R, Assumpção PP, Khayat AS, Smith Mde A, dos Santos AK, Burbano RR.

BMC Gastroenterol. 2013 Sep 23;13:141. doi: 10.1186/1471-230X-13-141.


p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases.

Yokobori T, Mimori K, Iwatsuki M, Ishii H, Onoyama I, Fukagawa T, Kuwano H, Nakayama KI, Mori M.

Cancer Res. 2009 May 1;69(9):3788-94. doi: 10.1158/0008-5472.CAN-08-2846. Epub 2009 Apr 14.


Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer.

Akhoondi S, Lindström L, Widschwendter M, Corcoran M, Bergh J, Spruck C, Grandér D, Sangfelt O.

Breast Cancer Res. 2010;12(6):R105. doi: 10.1186/bcr2788. Epub 2010 Dec 1.


Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.

Fang L, Yang Z, Zhou J, Tung JY, Hsiao CD, Wang L, Deng Y, Wang P, Wang J, Lee MH.

Mol Cancer Ther. 2015 Jun;14(6):1476-87. doi: 10.1158/1535-7163.MCT-15-0030. Epub 2015 Apr 8.


MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7.

Xu Y, Sengupta T, Kukreja L, Minella AC.

J Biol Chem. 2010 Nov 5;285(45):34439-46. doi: 10.1074/jbc.M110.152306. Epub 2010 Sep 7.


F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.

Yumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, Ohno S, Mori M, Mimori K, Nakayama KI.

J Clin Invest. 2015 Feb;125(2):621-35. doi: 10.1172/JCI78782. Epub 2015 Jan 2.


FBW7 increases drug sensitivity to cisplatin in human nasopharyngeal carcinoma by downregulating the expression of multidrug resistance-associated protein.

Song Y, Zhou X, Bai W, Ma X.

Tumour Biol. 2015 Jun;36(6):4197-202. doi: 10.1007/s13277-015-3056-4. Epub 2015 Jan 14.


FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.

Li N, Lorenzi F, Kalakouti E, Normatova M, Babaei-Jadidi R, Tomlinson I, Nateri AS.

Oncotarget. 2015 Apr 20;6(11):9240-56.


FBXW7 acts as an independent prognostic marker and inhibits tumor growth in human osteosarcoma.

Li Z, Xiao J, Hu K, Wang G, Li M, Zhang J, Cheng G.

Int J Mol Sci. 2015 Jan 22;16(2):2294-306. doi: 10.3390/ijms16022294.


Loss of FBXW7 is related to the susceptibility and poor prognosis of cervical squamous carcinoma.

Xu Y, Yu J, Liu T, Meng F, Kong D, Lou G.

Biomarkers. 2016;21(4):379-85. doi: 10.3109/1354750X.2016.1148778. Epub 2016 Mar 8.


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