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Items: 1 to 20 of 103


14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels.

Batra N, Riquelme MA, Burra S, Jiang JX.

J Cell Sci. 2014 Jan 1;127(Pt 1):137-46. doi: 10.1242/jcs.133553. Epub 2013 Oct 25.


Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation.

Batra N, Riquelme MA, Burra S, Kar R, Gu S, Jiang JX.

J Biol Chem. 2014 Apr 11;289(15):10582-91. doi: 10.1074/jbc.M114.550608. Epub 2014 Feb 22.


Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.

Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3359-64. doi: 10.1073/pnas.1115967109. Epub 2012 Feb 13.


"INTEGRINating" the connexin hemichannel function in bone osteocytes through the action of integrin α5.

Batra N, Jiang JX.

Commun Integr Biol. 2012 Sep 1;5(5):516-8. doi: 10.4161/cib.21322.


Connexin43 hemichannels mediate small molecule exchange between chondrocytes and matrix in biomechanically-stimulated temporomandibular joint cartilage.

Zhang J, Zhang HY, Zhang M, Qiu ZY, Wu YP, Callaway DA, Jiang JX, Lu L, Jing L, Yang T, Wang MQ.

Osteoarthritis Cartilage. 2014 Jun;22(6):822-30. doi: 10.1016/j.joca.2014.03.017. Epub 2014 Apr 3.


Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress.

Riquelme MA, Burra S, Kar R, Lampe PD, Jiang JX.

J Biol Chem. 2015 Nov 20;290(47):28321-8. doi: 10.1074/jbc.M115.683417. Epub 2015 Oct 6.


Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading.

Siller-Jackson AJ, Burra S, Gu S, Xia X, Bonewald LF, Sprague E, Jiang JX.

J Biol Chem. 2008 Sep 26;283(39):26374-82. doi: 10.1074/jbc.M803136200. Epub 2008 Jul 31.


Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration.

Thomas T, Jordan K, Simek J, Shao Q, Jedeszko C, Walton P, Laird DW.

J Cell Sci. 2005 Oct 1;118(Pt 19):4451-62. Epub 2005 Sep 13.


Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane.

Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM.

Circ Res. 2012 Mar 30;110(7):978-89. doi: 10.1161/CIRCRESAHA.111.257964. Epub 2012 Feb 9.


Cx43/beta-gal inhibits Cx43 transport in the Golgi apparatus.

Das Sarma J, Lo CW, Koval M.

Cell Commun Adhes. 2001;8(4-6):249-52.


Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice.

Bivi N, Pacheco-Costa R, Brun LR, Murphy TR, Farlow NR, Robling AG, Bellido T, Plotkin LI.

J Orthop Res. 2013 Jul;31(7):1075-81. doi: 10.1002/jor.22341. Epub 2013 Mar 11.


Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load.

Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ.

J Bone Miner Res. 2014 Feb;29(2):275-86. Review.


Mechanical loading stimulates expression of connexin 43 in alveolar bone cells in the tooth movement model.

Gluhak-Heinrich J, Gu S, Pavlin D, Jiang JX.

Cell Commun Adhes. 2006 Jan-Apr;13(1-2):115-25.


Cx43 and mechanotransduction in bone.

Plotkin LI, Speacht TL, Donahue HJ.

Curr Osteoporos Rep. 2015 Apr;13(2):67-72. doi: 10.1007/s11914-015-0255-2. Review.


Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin.

Cherian PP, Siller-Jackson AJ, Gu S, Wang X, Bonewald LF, Sprague E, Jiang JX.

Mol Biol Cell. 2005 Jul;16(7):3100-6. Epub 2005 Apr 20.


Connexin 43 channels protect osteocytes against oxidative stress-induced cell death.

Kar R, Riquelme MA, Werner S, Jiang JX.

J Bone Miner Res. 2013 Jul;28(7):1611-21. doi: 10.1002/jbmr.1917.


Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice.

Loiselle AE, Lloyd SA, Paul EM, Lewis GS, Donahue HJ.

PLoS One. 2013 Nov 8;8(11):e81399. doi: 10.1371/journal.pone.0081399. eCollection 2013.


Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels.

Burra S, Nicolella DP, Francis WL, Freitas CJ, Mueschke NJ, Poole K, Jiang JX.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13648-53. doi: 10.1073/pnas.1009382107. Epub 2010 Jul 19.

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