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Items: 1 to 20 of 99

1.

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

Li J, Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K.

Nat Neurosci. 2013 Dec;16(12):1745-53. doi: 10.1038/nn.3564. Epub 2013 Oct 27. Erratum in: Nat Neurosci. 2014 Sep;17(9):1286.

2.

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.

Li J, Chen J, Ricupero CL, Hart RP, Schwartz MS, Kusnecov A, Herrup K.

Nat Med. 2012 May;18(5):783-90. doi: 10.1038/nm.2709.

3.

The role of epigenomics in the neurodegeneration of ataxia-telangiectasia.

Li J, Jiang D.

Epigenomics. 2015;7(2):137-41. doi: 10.2217/epi.14.81. Review. No abstract available.

PMID:
25942530
4.

Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.

Shen X, Chen J, Li J, Kofler J, Herrup K.

eNeuro. 2016 Feb 27;3(1). pii: ENEURO.0124-15.2016. doi: 10.1523/ENEURO.0124-15.2016. eCollection 2016 Jan-Feb.

5.

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.

Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, Reinberg D.

Genes Dev. 2010 Dec 1;24(23):2615-20. doi: 10.1101/gad.1983810.

6.

Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.

Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K.

Mol Cancer Ther. 2006 Dec;5(12):3096-104.

8.

Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus.

Jie B, Weilong C, Ming C, Fei X, Xinghua L, Junhua C, Guobin W, Kaixiong T, Xiaoming S.

Int J Biochem Cell Biol. 2015 Aug;65:104-12. doi: 10.1016/j.biocel.2015.05.011. Epub 2015 May 22.

PMID:
26004298
9.

The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration.

Lavin MF.

DNA Repair (Amst). 2013 Aug;12(8):612-9. doi: 10.1016/j.dnarep.2013.04.014. Epub 2013 Jun 2. Review.

PMID:
23731731
10.

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.

Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M, van Zundert B.

Mol Cell Neurosci. 2013 Nov;57:130-43. doi: 10.1016/j.mcn.2013.07.012. Epub 2013 Aug 8.

PMID:
23932971
11.

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, Iwama A.

Blood. 2011 Dec 15;118(25):6553-61. doi: 10.1182/blood-2011-03-340554. Epub 2011 Oct 31. Erratum in: Blood. 2012 Jul 26;120(4):924.

12.

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.

Tsang DP, Wu WK, Kang W, Lee YY, Wu F, Yu Z, Xiong L, Chan AW, Tong JH, Yang W, Li MS, Lau SS, Li X, Lee SD, Yang Y, Lai PB, Yu DY, Xu G, Lo KW, Chan MT, Wang H, Lee TL, Yu J, Wong N, Yip KY, To KF, Cheng AS.

J Pathol. 2016 Apr;238(5):651-64. doi: 10.1002/path.4688.

PMID:
26800240
13.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH.

Mol Cell. 2008 Nov 21;32(4):491-502. doi: 10.1016/j.molcel.2008.10.016.

14.

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation.

Sahasrabuddhe AA, Chen X, Chung F, Velusamy T, Lim MS, Elenitoba-Johnson KS.

Oncogene. 2015 Jan 22;34(4):445-54. doi: 10.1038/onc.2013.571. Epub 2014 Jan 27.

PMID:
24469040
15.

Downregulation of Ezh2 methyltransferase by FOXP3: new insight of FOXP3 into chromatin remodeling?

Shen Z, Chen L, Yang X, Zhao Y, Pier E, Zhang X, Yang X, Xiong Y.

Biochim Biophys Acta. 2013 Oct;1833(10):2190-200. doi: 10.1016/j.bbamcr.2013.05.014. Epub 2013 May 17.

16.

Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells.

Dreger H, Ludwig A, Weller A, Stangl V, Baumann G, Meiners S, Stangl K.

Hypertension. 2012 Nov;60(5):1176-83. doi: 10.1161/HYPERTENSIONAHA.112.191098. Epub 2012 Sep 10.

17.

Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5028-33. doi: 10.1073/pnas.1202258109. Epub 2012 Mar 6.

18.

Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.

Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D.

Mol Cell Biol. 2008 Apr;28(8):2718-31. doi: 10.1128/MCB.02017-07. Epub 2008 Feb 19.

19.

Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.

Rimkus SA, Katzenberger RJ, Trinh AT, Dodson GE, Tibbetts RS, Wassarman DA.

Genes Dev. 2008 May 1;22(9):1205-20. doi: 10.1101/gad.1639608. Epub 2008 Apr 11.

20.

ATM and the epigenetics of the neuronal genome.

Herrup K.

Mech Ageing Dev. 2013 Oct;134(10):434-9. doi: 10.1016/j.mad.2013.05.005. Epub 2013 May 23. Review.

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