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Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice.

Bojic LA, Burke AC, Chhoker SS, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Tirona RG, Yin H, Pickering JG, Huff MW.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):52-60. doi: 10.1161/ATVBAHA.113.301830. Epub 2013 Oct 24.


PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity.

Bojic LA, Telford DE, Fullerton MD, Ford RJ, Sutherland BG, Edwards JY, Sawyez CG, Gros R, Kemp BE, Steinberg GR, Huff MW.

J Lipid Res. 2014 Jul;55(7):1254-66. doi: 10.1194/jlr.M046037. Epub 2014 May 26.


Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr-/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid.

Samsoondar JP, Burke AC, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Pinkosky SL, Newton RS, Huff MW.

Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):647-656. doi: 10.1161/ATVBAHA.116.308963. Epub 2017 Feb 2.


Peroxisome proliferator-activated receptor δ: a multifaceted metabolic player.

Bojic LA, Huff MW.

Curr Opin Lipidol. 2013 Apr;24(2):171-7. doi: 10.1097/MOL.0b013e32835cc949. Review.


Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway.

Cheang WS, Tian XY, Wong WT, Lau CW, Lee SS, Chen ZY, Yao X, Wang N, Huang Y.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):830-6. doi: 10.1161/ATVBAHA.113.301938. Epub 2014 Jan 30.


Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice.

Mulvihill EE, Assini JM, Sutherland BG, DiMattia AS, Khami M, Koppes JB, Sawyez CG, Whitman SC, Huff MW.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):742-8. doi: 10.1161/ATVBAHA.109.201095. Epub 2010 Jan 28.


KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice.

Potì F, Gualtieri F, Sacchi S, Weißen-Plenz G, Varga G, Brodde M, Weber C, Simoni M, Nofer JR.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12. doi: 10.1161/ATVBAHA.113.301347. Epub 2013 May 2.


Peroxisome proliferator activated receptor-δ: the middle child vies for attention.

Rajagopal R, Semenkovich CF.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):5-7. doi: 10.1161/ATVBAHA.113.302777. No abstract available. Erratum in: Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):e5.


PPARδ activation protects endothelial function in diabetic mice.

Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y.

Diabetes. 2012 Dec;61(12):3285-93. doi: 10.2337/db12-0117. Epub 2012 Aug 28.


The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.

Graham TL, Mookherjee C, Suckling KE, Palmer CN, Patel L.

Atherosclerosis. 2005 Jul;181(1):29-37. Erratum in: Atherosclerosis. 2005 Oct;182(2):381.


Activation of peroxisome proliferator-activated receptor δ inhibits human macrophage foam cell formation and the inflammatory response induced by very low-density lipoprotein.

Bojic LA, Sawyez CG, Telford DE, Edwards JY, Hegele RA, Huff MW.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2919-28. doi: 10.1161/ATVBAHA.112.255208. Epub 2012 Sep 27.


Attenuation of early atherogenesis in low-density lipoprotein receptor-deficient mice by proteasome inhibition.

Wilck N, Fechner M, Dreger H, Hewing B, Arias A, Meiners S, Baumann G, Stangl V, Stangl K, Ludwig A.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1418-26. doi: 10.1161/ATVBAHA.112.249342. Epub 2012 Apr 19.


Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.

Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P.

Circulation. 2004 Nov 16;110(20):3259-69. Epub 2004 Nov 8.


Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF.

Circulation. 2007 Sep 18;116(12):1404-12. Epub 2007 Aug 27.


Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr⁻/⁻ mice compared to nondiabetic LDLr⁻/⁻ mice.

Engelbertsen D, To F, Dunér P, Kotova O, Söderberg I, Alm R, Gomez MF, Nilsson J, Bengtsson E.

Exp Diabetes Res. 2012;2012:176162. doi: 10.1155/2012/176162. Epub 2012 Nov 28.


Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.

Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, Huff MW.

Diabetes. 2009 Oct;58(10):2198-210. doi: 10.2337/db09-0634. Epub 2009 Jul 10.


PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.

Ye JM, Tid-Ang J, Turner N, Zeng XY, Li HY, Cooney GJ, Wulff EM, Sauerberg P, Kraegen EW.

Br J Pharmacol. 2011 Jun;163(3):556-66. doi: 10.1111/j.1476-5381.2011.01240.x.


Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice.

Rensing KL, de Jager SC, Stroes ES, Vos M, Twickler MT, Dallinga-Thie GM, de Vries CJ, Kuiper J, Bot I, von der Thüsen JH.

Cardiovasc Res. 2014 Feb 1;101(2):277-87. doi: 10.1093/cvr/cvt252. Epub 2013 Nov 12.


Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice.

Wu HT, Chen CT, Cheng KC, Li YX, Yeh CH, Cheng JT.

Horm Metab Res. 2011 Aug;43(9):631-5. doi: 10.1055/s-0031-1280781. Epub 2011 Jul 1.


Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice.

Rinne P, Silvola JM, Hellberg S, Ståhle M, Liljenbäck H, Salomäki H, Koskinen E, Nuutinen S, Saukko P, Knuuti J, Saraste A, Roivainen A, Savontaus E.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1346-54. doi: 10.1161/ATVBAHA.113.302963. Epub 2014 May 1.

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