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Items: 1 to 20 of 73

1.

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling.

Nan X, Collisson EA, Lewis S, Huang J, Tamgüney TM, Liphardt JT, McCormick F, Gray JW, Chu S.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18519-24. doi: 10.1073/pnas.1318188110. Epub 2013 Oct 24.

2.

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway.

Nan X, Tamgüney TM, Collisson EA, Lin LJ, Pitt C, Galeas J, Lewis S, Gray JW, McCormick F, Chu S.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):7996-8001. doi: 10.1073/pnas.1509123112. Epub 2015 Jun 16.

3.

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.

Rebocho AP, Marais R.

Oncogene. 2013 Jun 27;32(26):3207-12. doi: 10.1038/onc.2012.330. Epub 2012 Aug 27.

PMID:
22926515
4.

Raf inhibitors target ras spatiotemporal dynamics.

Cho KJ, Kasai RS, Park JH, Chigurupati S, Heidorn SJ, van der Hoeven D, Plowman SJ, Kusumi A, Marais R, Hancock JF.

Curr Biol. 2012 Jun 5;22(11):945-55. doi: 10.1016/j.cub.2012.03.067. Epub 2012 May 3.

5.

Photoactivated Localization Microscopy with Bimolecular Fluorescence Complementation (BiFC-PALM).

Nickerson A, Huang T, Lin LJ, Nan X.

J Vis Exp. 2015 Dec 22;(106):e53154. doi: 10.3791/53154.

6.

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM.

J Biol Chem. 1995 Nov 10;270(45):26802-6.

7.

H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis.

Roy S, Wyse B, Hancock JF.

Mol Cell Biol. 2002 Jul;22(14):5128-40.

8.

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y, Van Horn RD, Yin T, Zhang X, Yadav V, Chen SH, Gong X, Ma X, Webster Y, Buchanan S, Mochalkin I, Huber L, Kays L, Donoho GP, Walgren J, McCann D, Patel P, Conti I, Plowman GD, Starling JJ, Flynn DL.

Cancer Cell. 2015 Sep 14;28(3):384-98. doi: 10.1016/j.ccell.2015.08.002. Epub 2015 Sep 3.

9.

Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis.

Hibino K, Shibata T, Yanagida T, Sako Y.

J Biol Chem. 2011 Oct 21;286(42):36460-8. doi: 10.1074/jbc.M111.262675. Epub 2011 Aug 23.

10.

Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.

Patriotis C, Makris A, Chernoff J, Tsichlis PN.

Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9755-9.

11.

Interactions between Ras and Raf: key regulatory proteins in cellular transformation.

Marshall M.

Mol Reprod Dev. 1995 Dec;42(4):493-9. Review.

PMID:
8607981
12.
13.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Blaževitš O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D.

Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165.

14.

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF.

Recent Prog Horm Res. 2001;56:127-55. Review.

PMID:
11237210
15.

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane.

Leevers SJ, Paterson HF, Marshall CJ.

Nature. 1994 Jun 2;369(6479):411-4.

PMID:
8196769
16.

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.

Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6067-72. doi: 10.1073/pnas.1102554108. Epub 2011 Mar 25.

17.

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T.

Nat Cell Biol. 2005 Aug;7(8):837-43. Epub 2005 Jul 24.

18.

Formation of the Ras dimer is essential for Raf-1 activation.

Inouye K, Mizutani S, Koide H, Kaziro Y.

J Biol Chem. 2000 Feb 11;275(6):3737-40.

19.

Function of the Rho family GTPases in Ras-stimulated Raf activation.

Li W, Chong H, Guan KL.

J Biol Chem. 2001 Sep 14;276(37):34728-37. Epub 2001 Jul 16.

20.

Ras is not required for the interleukin 3-induced proliferation of a mouse pro-B cell line, BaF3.

Terada K, Kaziro Y, Satoh T.

J Biol Chem. 1995 Nov 17;270(46):27880-6.

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