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Items: 1 to 20 of 102


Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response.

Samokhvalov V, Alsaleh N, El-Sikhry HE, Jamieson KL, Chen CB, Lopaschuk DG, Carter C, Light PE, Manne R, Falck JR, Seubert JM.

Cell Death Dis. 2013 Oct 24;4:e885. doi: 10.1038/cddis.2013.418.


Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.

El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM.

PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016.


Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.

Batchu SN, Lee SB, Qadhi RS, Chaudhary KR, El-Sikhry H, Kodela R, Falck JR, Seubert JM.

Br J Pharmacol. 2011 Feb;162(4):897-907. doi: 10.1111/j.1476-5381.2010.01093.x.


PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS.

Samokhvalov V, Vriend J, Jamieson KL, Akhnokh MK, Manne R, Falck JR, Seubert JM.

Front Pharmacol. 2014 Nov 11;5:242. doi: 10.3389/fphar.2014.00242. eCollection 2014.


Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

Katragadda D, Batchu SN, Cho WJ, Chaudhary KR, Falck JR, Seubert JM.

J Mol Cell Cardiol. 2009 Jun;46(6):867-75. doi: 10.1016/j.yjmcc.2009.02.028. Epub 2009 Mar 12.


Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms.

Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, Lee HC.

J Physiol. 2006 Sep 1;575(Pt 2):627-44. Epub 2006 Jun 22.


Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection.

Batchu SN, Chaudhary KR, El-Sikhry H, Yang W, Light PE, Oudit GY, Seubert JM.

J Mol Cell Cardiol. 2012 Jul;53(1):43-52. doi: 10.1016/j.yjmcc.2012.04.008. Epub 2012 Apr 27.


Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes.

Lu T, Hoshi T, Weintraub NL, Spector AA, Lee HC.

J Physiol. 2001 Dec 15;537(Pt 3):811-27.


Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2838-44. doi: 10.1152/ajpheart.00186.2008. Epub 2008 Apr 25.


CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKα2 and enhancing nuclear translocation of Akt1.

Wang B, Zeng H, Wen Z, Chen C, Wang DW.

Aging Cell. 2016 Oct;15(5):940-52. doi: 10.1111/acel.12507. Epub 2016 Jul 14.


Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids.

Lu T, Hong MP, Lee HC.

J Biol Chem. 2005 May 13;280(19):19097-104. Epub 2005 Mar 10.


Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.

Xu M, Hao H, Jiang L, Wei Y, Zhou F, Sun J, Zhang J, Ji H, Wang G, Ju W, Li P.

Drug Metab Dispos. 2016 Jul;44(7):878-87. doi: 10.1124/dmd.116.069914. Epub 2016 May 5.


Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.

Merkel MJ, Liu L, Cao Z, Packwood W, Young J, Alkayed NJ, Van Winkle DM.

Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H679-87. doi: 10.1152/ajpheart.00533.2009. Epub 2009 Dec 11.


Regulation of forskolin-induced cAMP production by cytochrome P450 epoxygenase metabolites of arachidonic acid in HEK293 cells.

Abukhashim M, Wiebe GJ, Seubert JM.

Cell Biol Toxicol. 2011 Oct;27(5):321-32. doi: 10.1007/s10565-011-9190-x. Epub 2011 Apr 26.


Trimetazidine Protects Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Promoting AMP-activated Protein Kinase-dependent Autophagic Flux.

Zhong Y, Zhong P, He S, Zhang Y, Tang L, Ling Y, Fu S, Tang Y, Yang P, Luo T, Chen B, Chen A, Wang X.

J Cardiovasc Pharmacol. 2017 Jun;69(6):389-397. doi: 10.1097/FJC.0000000000000487.


Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs.

Pratt PF, Li P, Hillard CJ, Kurian J, Campbell WB.

Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1113-21.


Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.

Gross GJ, Hsu A, Falck JR, Nithipatikom K.

J Mol Cell Cardiol. 2007 Mar;42(3):687-91. Epub 2007 Jan 10.


Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.

Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.

Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H537-42. Epub 2006 Feb 10.


Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice.

Chaudhary KR, Zordoky BN, Edin ML, Alsaleh N, El-Kadi AO, Zeldin DC, Seubert JM.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:8-17. doi: 10.1016/j.prostaglandins.2012.08.001. Epub 2012 Aug 16.


Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes.

Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR.

Stroke. 1996 May;27(5):971-9.


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