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IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner.

Chiba Y, Mizoguchi I, Mitobe K, Higuchi K, Nagai H, Nishigori C, Mizuguchi J, Yoshimoto T.

PLoS One. 2013 Oct 14;8(10):e76159. doi: 10.1371/journal.pone.0076159. eCollection 2013.


Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells.

Bernardo AR, Cosgaya JM, Aranda A, Jiménez-Lara AM.

Cell Death Dis. 2013 Jan 31;4:e479. doi: 10.1038/cddis.2013.5.


Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells.

Chuang JH, Chuang HC, Huang CC, Wu CL, Du YY, Kung ML, Chen CH, Chen SC, Tai MH.

J Biomed Sci. 2011 Aug 23;18:65. doi: 10.1186/1423-0127-18-65.


Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis.

Yoneda K, Sugimoto K, Shiraki K, Tanaka J, Beppu T, Fuke H, Yamamoto N, Masuya M, Horie R, Uchida K, Takei Y.

Int J Oncol. 2008 Nov;33(5):929-36.


The functional expression of TLR3 in EPCs impairs cell proliferation by induction of cell apoptosis and cell cycle progress inhibition.

Yang M, Xiao Z, Lv Q, Liu X, Zhou L, Chen X, Chen M, Fang L, Xie X, Hu J.

Int Immunopharmacol. 2011 Dec;11(12):2118-24. doi: 10.1016/j.intimp.2011.09.005. Epub 2011 Sep 29.


Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts.

Lin LL, Huang CC, Wu CL, Wu MT, Hsu WM, Chuang JH.

Lab Invest. 2016 Jul;96(7):719-30. doi: 10.1038/labinvest.2016.57. Epub 2016 May 16.


Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway.

Jiang Q, Wei H, Tian Z.

BMC Cancer. 2008 Jan 17;8:12. doi: 10.1186/1471-2407-8-12.


Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells.

Tu Z, Hamalainen-Laanaya HK, Crispe IN, Orloff MS.

Cell Immunol. 2011;271(2):286-91. doi: 10.1016/j.cellimm.2011.07.006. Epub 2011 Jul 20.


Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness.

Bugge M, Bergstrom B, Eide OK, Solli H, Kjønstad IF, Stenvik J, Espevik T, Nilsen NJ.

J Biol Chem. 2017 Sep 15;292(37):15408-15425. doi: 10.1074/jbc.M117.784090. Epub 2017 Jul 17.


Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: Relationship to Bcl-2 family and caspase activation.

Hamaï A, Richon C, Meslin F, Faure F, Kauffmann A, Lecluse Y, Jalil A, Larue L, Avril MF, Chouaib S, Mehrpour M.

Oncogene. 2006 Dec 7;25(58):7618-34. Epub 2006 Sep 18. Erratum in: Oncogene. 2007 Feb 22;26(8):1256.


Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth.

Chuang JH, Lin TK, Tai MH, Liou CW, Huang ST, Wu CL, Lin HY, Wang PW.

Apoptosis. 2012 Apr;17(4):335-48. doi: 10.1007/s10495-011-0686-x.


Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells.

Baiersdörfer M, Schwarz M, Seehafer K, Lehmann C, Heit A, Wagner H, Kirschning CJ, Koch-Brandt C.

Exp Cell Res. 2010 Dec 10;316(20):3489-500. doi: 10.1016/j.yexcr.2010.07.022. Epub 2010 Aug 5.


Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P.

Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4565-74.


Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha).

Sun R, Zhang Y, Lv Q, Liu B, Jin M, Zhang W, He Q, Deng M, Liu X, Li G, Li Y, Zhou G, Xie P, Xie X, Hu J, Duan Z.

J Biol Chem. 2011 May 6;286(18):15918-28. doi: 10.1074/jbc.M110.178798. Epub 2011 Mar 2.


Temporally designed treatment of melanoma cells by ATRA and polyI: C results in enhanced chemokine and IFNβ secretion controlled differently by TLR3 and MDA5.

Szabo A, Osman RM, Bacskai I, Kumar BV, Agod Z, Lanyi A, Gogolak P, Rajnavolgyi E.

Melanoma Res. 2012 Oct;22(5):351-61. doi: 10.1097/CMR.0b013e328357076c.


Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells.

Harashima N, Inao T, Imamura R, Okano S, Suda T, Harada M.

Cancer Immunol Immunother. 2012 May;61(5):667-76. doi: 10.1007/s00262-011-1132-1. Epub 2011 Oct 29.


Polyinosinic-Polycytidylic Acid Perturbs Ovarian Functions Through Toll-Like Receptor 3-Mediated Tumor Necrosis Factor A Production in Female Mice.

Yan K, Cheng L, Liu P, Liu Z, Zhao S, Zhu W, Wang Q, Wu H, Han D.

Biol Reprod. 2015 Jul;93(1):11. doi: 10.1095/biolreprod.115.128348. Epub 2015 Jun 3.


The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma.

Nojiri K, Sugimoto K, Shiraki K, Tameda M, Inagaki Y, Kusagawa S, Ogura S, Tanaka J, Yoneda M, Yamamoto N, Okano H, Takei Y, Ito M, Kasai C, Inoue H, Takase K.

Oncol Rep. 2013 May;29(5):1737-43. doi: 10.3892/or.2013.2322. Epub 2013 Mar 4.


Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression.

Galli R, Paone A, Fabbri M, Zanesi N, Calore F, Cascione L, Acunzo M, Stoppacciaro A, Tubaro A, Lovat F, Gasparini P, Fadda P, Alder H, Volinia S, Filippini A, Ziparo E, Riccioli A, Croce CM.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9812-7. doi: 10.1073/pnas.1304610110. Epub 2013 May 28.

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