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Items: 1 to 20 of 167

1.

Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.

Marschall M, Niemann I, Kosulin K, Bootz A, Wagner S, Dobner T, Herz T, Kramer B, Leban J, Vitt D, Stamminger T, Hutterer C, Strobl S.

Antiviral Res. 2013 Dec;100(3):640-8. doi: 10.1016/j.antiviral.2013.10.003. Epub 2013 Oct 20.

PMID:
24149002
2.

Inhibition of dengue virus through suppression of host pyrimidine biosynthesis.

Wang QY, Bushell S, Qing M, Xu HY, Bonavia A, Nunes S, Zhou J, Poh MK, Florez de Sessions P, Niyomrattanakit P, Dong H, Hoffmaster K, Goh A, Nilar S, Schul W, Jones S, Kramer L, Compton T, Shi PY.

J Virol. 2011 Jul;85(13):6548-56. doi: 10.1128/JVI.02510-10. Epub 2011 Apr 20.

3.

[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].

Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H.

Med Sci (Paris). 2015 Jan;31(1):98-104. doi: 10.1051/medsci/20153101019. Epub 2015 Feb 6. Review. French.

4.

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jan 22;58(2):860-77. doi: 10.1021/jm501446r. Epub 2015 Jan 6.

PMID:
25558988
5.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jul 23;58(14):5579-98. doi: 10.1021/acs.jmedchem.5b00606. Epub 2015 Jun 30.

6.

Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture.

Schnellrath LC, Damaso CR.

Int J Antimicrob Agents. 2011 Nov;38(5):435-41. doi: 10.1016/j.ijantimicag.2011.07.002. Epub 2011 Aug 12.

7.

New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.

Shuto S, Obara T, Saito Y, Andrei G, Snoeck R, De Clercq E, Matsuda A.

J Med Chem. 1996 Jun 7;39(12):2392-9.

PMID:
8691433
8.
9.

Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.

Zameitat E, Freymark G, Dietz CD, Löffler M, Bölker M.

Appl Environ Microbiol. 2007 May;73(10):3371-9. Epub 2007 Mar 16.

10.

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.

Grandin C, Hourani ML, Janin YL, Dauzonne D, Munier-Lehmann H, Paturet A, Taborik F, Vabret A, Contamin H, Tangy F, Vidalain PO.

Antiviral Res. 2016 Jan;125:58-62. doi: 10.1016/j.antiviral.2015.11.006. Epub 2015 Nov 22.

PMID:
26593978
11.

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.

Hoffmann HH, Kunz A, Simon VA, Palese P, Shaw ML.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5777-82. doi: 10.1073/pnas.1101143108. Epub 2011 Mar 21.

12.

Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses.

Efferth T, Marschall M, Wang X, Huong SM, Hauber I, Olbrich A, Kronschnabl M, Stamminger T, Huang ES.

J Mol Med (Berl). 2002 Apr;80(4):233-42. Epub 2001 Dec 8.

PMID:
11976732
13.

D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis.

Smee DF, Hurst BL, Day CW.

Antivir Chem Chemother. 2012 Aug 21;22(6):263-72. doi: 10.3851/IMP2105.

PMID:
22516927
14.

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response.

Cheung NN, Lai KK, Dai J, Kok KH, Chen H, Chan KH, Yuen KY, Kao RYT.

J Gen Virol. 2017 May;98(5):946-954. doi: 10.1099/jgv.0.000758. Epub 2017 May 30.

PMID:
28555543
15.

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.

Bonomo S, Tosco P, Giorgis M, Lolli M, Fruttero R.

J Mol Model. 2013 Mar;19(3):1099-107. doi: 10.1007/s00894-012-1643-5. Epub 2012 Nov 10.

16.

A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.

Hutterer C, Eickhoff J, Milbradt J, Korn K, Zeitträger I, Bahsi H, Wagner S, Zischinsky G, Wolf A, Degenhart C, Unger A, Baumann M, Klebl B, Marschall M.

Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71. doi: 10.1128/AAC.04534-14. Epub 2015 Jan 26.

17.

Discovery of a novel series of inhibitors of human cytomegalovirus primase.

Cushing TD, Adrian J, Chen X, DiMaio H, Doughan B, Flygare J, Liang L, Mayorga V, Miao S, Mellon H, Peterson MG, Powers JP, Spector F, Stein C, Wright M, Xu D, Ye Q, Jaen J.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4879-83. Epub 2006 Jun 30.

PMID:
16814545
18.

Biaryl analogues of teriflunomide as potent DHODH inhibitors.

Erra M, Moreno I, Sanahuja J, Andrés M, Reinoso RF, Lozoya E, Pizcueta P, Godessart N, Castro-Palomino JC.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7268-72. doi: 10.1016/j.bmcl.2011.10.052. Epub 2011 Oct 20.

PMID:
22078215
19.

Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.

Brancale A, McGuigan C, Algain B, Savy P, Benhida R, Fourrey JL, Andrei G, Snoeck R, De Clercq E, Balzarini J.

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2507-10.

PMID:
11549457
20.

Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases.

Leban J, Vitt D.

Arzneimittelforschung. 2011;61(1):66-72. doi: 10.1055/s-0031-1296169. Review.

PMID:
21355448

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