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Items: 1 to 20 of 119


Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.

Muretta JM, Behnke-Parks WM, Major J, Petersen KJ, Goulet A, Moores CA, Thomas DD, Rosenfeld SS.

J Biol Chem. 2013 Nov 29;288(48):34839-49. doi: 10.1074/jbc.M113.518845. Epub 2013 Oct 21.


"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.

Kaan HY, Major J, Tkocz K, Kozielski F, Rosenfeld SS.

J Biol Chem. 2013 Jun 21;288(25):18588-98. doi: 10.1074/jbc.M113.462648. Epub 2013 May 8.


Loop L5 acts as a conformational latch in the mitotic kinesin Eg5.

Behnke-Parks WM, Vendome J, Honig B, Maliga Z, Moores C, Rosenfeld SS.

J Biol Chem. 2011 Feb 18;286(7):5242-53. doi: 10.1074/jbc.M110.192930. Epub 2010 Dec 9.


The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.

Muretta JM, Jun Y, Gross SP, Major J, Thomas DD, Rosenfeld SS.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6606-13. doi: 10.1073/pnas.1512305112. Epub 2015 Nov 16.


Mechanistic analysis of the mitotic kinesin Eg5.

Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP.

J Biol Chem. 2004 Sep 10;279(37):38861-70. Epub 2004 Jul 6.


Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop.

Ishikawa K, Tamura Y, Maruta S.

J Biochem. 2014 Mar;155(3):195-206. doi: 10.1093/jb/mvt111. Epub 2013 Dec 10.


Docking and rolling, a model of how the mitotic motor Eg5 works.

Rosenfeld SS, Xing J, Jefferson GM, King PH.

J Biol Chem. 2005 Oct 21;280(42):35684-95. Epub 2005 Aug 22.


Monastrol inhibition of the mitotic kinesin Eg5.

Cochran JC, Gatial JE 3rd, Kapoor TM, Gilbert SP.

J Biol Chem. 2005 Apr 1;280(13):12658-67. Epub 2005 Jan 23.


The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.

Waitzman JS, Larson AG, Cochran JC, Naber N, Cooke R, Jon Kull F, Pate E, Rice SE.

Biophys J. 2011 Dec 7;101(11):2760-9. doi: 10.1016/j.bpj.2011.10.032.


Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

Brier S, Lemaire D, Debonis S, Forest E, Kozielski F.

Biochemistry. 2004 Oct 19;43(41):13072-82.


The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner.

Bell KM, Cha HK, Sindelar CV, Cochran JC.

J Biol Chem. 2017 Sep 1;292(35):14680-14694. doi: 10.1074/jbc.M117.797662. Epub 2017 Jul 12.


The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.

Larson AG, Naber N, Cooke R, Pate E, Rice SE.

Biophys J. 2010 Jun 2;98(11):2619-27. doi: 10.1016/j.bpj.2010.03.014.


A pathway of structural changes produced by monastrol binding to Eg5.

Maliga Z, Xing J, Cheung H, Juszczak LJ, Friedman JM, Rosenfeld SS.

J Biol Chem. 2006 Mar 24;281(12):7977-82. Epub 2006 Jan 23.


A structural model for monastrol inhibition of dimeric kinesin Eg5.

Krzysiak TC, Wendt T, Sproul LR, Tittmann P, Gross H, Gilbert SP, Hoenger A.

EMBO J. 2006 May 17;25(10):2263-73. Epub 2006 Apr 27.


Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.

Atherton J, Farabella I, Yu IM, Rosenfeld SS, Houdusse A, Topf M, Moores CA.

Elife. 2014 Sep 10;3:e03680. doi: 10.7554/eLife.03680.


Kinesin-5: cross-bridging mechanism to targeted clinical therapy.

Wojcik EJ, Buckley RS, Richard J, Liu L, Huckaba TM, Kim S.

Gene. 2013 Dec 1;531(2):133-49. doi: 10.1016/j.gene.2013.08.004. Epub 2013 Aug 14. Review.


A new look at the microtubule binding patterns of dimeric kinesins.

Hoenger A, Thormählen M, Diaz-Avalos R, Doerhoefer M, Goldie KN, Müller J, Mandelkow E.

J Mol Biol. 2000 Apr 14;297(5):1087-103.


The structural basis of force generation by the mitotic motor kinesin-5.

Goulet A, Behnke-Parks WM, Sindelar CV, Major J, Rosenfeld SS, Moores CA.

J Biol Chem. 2012 Dec 28;287(53):44654-66. doi: 10.1074/jbc.M112.404228. Epub 2012 Nov 7.

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