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Items: 1 to 20 of 53

1.

Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1.

Kida T, Omori K, Hori M, Ozaki H, Murata T.

J Pharmacol Exp Ther. 2014 Jan;348(1):125-30. doi: 10.1124/jpet.113.209288. Epub 2013 Oct 21.

PMID:
24144793
2.

Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.

Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1663-9. doi: 10.1161/ATVBAHA.113.301565. Epub 2013 Apr 25.

PMID:
23619297
3.

Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.

Kobayashi K, Tsubosaka Y, Hori M, Narumiya S, Ozaki H, Murata T.

Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):565-71. doi: 10.1161/ATVBAHA.112.300993. Epub 2013 Jan 10.

PMID:
23307871
4.

cAMP protects endothelial barrier functions by preventing Rac-1 inhibition.

Waschke J, Drenckhahn D, Adamson RH, Barth H, Curry FE.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2427-33. Epub 2004 Jul 22.

PMID:
15271660
5.

Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation.

Li AQ, Zhao L, Zhou TF, Zhang MQ, Qin XM.

Am J Physiol Cell Physiol. 2015 Jan 15;308(2):C164-75. doi: 10.1152/ajpcell.00249.2014. Epub 2014 Nov 5.

PMID:
25377089
6.

PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction.

Qiao J, Huang F, Lum H.

Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L972-80. Epub 2003 Feb 14.

PMID:
12588708
7.

Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: role of RhoA and Rac1.

Aslam M, Gündüz D, Schuler D, Li L, Sharifpanah F, Sedding D, Piper HM, Noll T.

Cardiovasc Res. 2011 Nov 1;92(2):276-86. doi: 10.1093/cvr/cvr213. Epub 2011 Aug 4.

PMID:
21816966
8.

Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells.

Gonzalez E, Kou R, Michel T.

J Biol Chem. 2006 Feb 10;281(6):3210-6. Epub 2005 Dec 8.

PMID:
16339142
9.

Low-Dose Endothelial Monocyte-Activating Polypeptide-II Induces Blood-Tumor Barrier Opening Via the cAMP/PKA/Rac1 Pathway.

Li Z, Liu XB, Liu YH, Xue YX, Liu J, Teng H, Xi Z, Yao YL.

J Mol Neurosci. 2016 Feb;58(2):153-61. doi: 10.1007/s12031-015-0649-8. Epub 2015 Sep 10.

PMID:
26358039
10.

Regulation of endothelial barrier function by the cAMP-dependent protein kinase.

Patterson CE, Lum H, Schaphorst KL, Verin AD, Garcia JG.

Endothelium. 2000;7(4):287-308.

PMID:
11201526
11.

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG.

J Biol Chem. 2005 Apr 29;280(17):17286-93. Epub 2005 Feb 14.

PMID:
15710622
12.

Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin-induced barrier failure in endothelial cell monolayers.

Aslam M, Pfeil U, Gündüz D, Rafiq A, Kummer W, Piper HM, Noll T.

Br J Pharmacol. 2012 Jan;165(1):208-22. doi: 10.1111/j.1476-5381.2011.01540.x.

PMID:
21671901
13.

Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.

Kou R, Sartoretto J, Michel T.

J Biol Chem. 2009 May 29;284(22):14734-43. doi: 10.1074/jbc.M808664200. Epub 2009 Mar 30.

PMID:
19332549
14.
15.
16.

cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.

Aslam M, Härtel FV, Arshad M, Gündüz D, Abdallah Y, Sauer H, Piper HM, Noll T.

Cardiovasc Res. 2010 Jul 15;87(2):375-84. doi: 10.1093/cvr/cvq065. Epub 2010 Mar 3.

PMID:
20202976
18.

Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement.

Liu F, Verin AD, Borbiev T, Garcia JG.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1309-17.

PMID:
11350812
19.

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.

Wimmer R, Hohenester S, Pusl T, Denk GU, Rust C, Beuers U.

Gut. 2008 Oct;57(10):1448-54. doi: 10.1136/gut.2007.140871. Epub 2008 Jun 26.

PMID:
18583398
20.

cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier- a signaling pathway compromised in inflammation.

Schlegel N, Waschke J.

Cell Tissue Res. 2014 Mar;355(3):587-96. doi: 10.1007/s00441-013-1755-y. Epub 2013 Dec 10. Review.

PMID:
24322391

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