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Items: 1 to 20 of 110

1.

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells.

Kaneko S, Son J, Shen SS, Reinberg D, Bonasio R.

Nat Struct Mol Biol. 2013 Nov;20(11):1258-64. doi: 10.1038/nsmb.2700. Epub 2013 Oct 20.

2.

MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells.

Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ, Zhou Q.

J Biol Chem. 2013 Aug 16;288(33):23659-65. doi: 10.1074/jbc.M113.475608. Epub 2013 Jul 2.

3.

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.

Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S.

Genome Biol. 2013 Aug 29;14(8):R91. doi: 10.1186/gb-2013-14-8-r91.

4.

Polycomb Repressive Complex 2 regulates lineage fidelity during embryonic stem cell differentiation.

Thornton SR, Butty VL, Levine SS, Boyer LA.

PLoS One. 2014 Oct 21;9(10):e110498. doi: 10.1371/journal.pone.0110498. eCollection 2014.

5.

Nascent RNA interaction keeps PRC2 activity poised and in check.

Kaneko S, Son J, Bonasio R, Shen SS, Reinberg D.

Genes Dev. 2014 Sep 15;28(18):1983-8. doi: 10.1101/gad.247940.114. Epub 2014 Aug 28.

6.

Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation.

Obier N, Lin Q, Cauchy P, Hornich V, Zenke M, Becker M, Müller AM.

Stem Cell Rev. 2015 Feb;11(1):50-61. doi: 10.1007/s12015-014-9550-z.

PMID:
25134795
7.

A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming.

Chan YS, Göke J, Lu X, Venkatesan N, Feng B, Su IH, Ng HH.

Stem Cells. 2013 Apr;31(4):682-92. doi: 10.1002/stem.1307.

8.

E2f6-mediated repression of the meiotic Stag3 and Smc1β genes during early embryonic development requires Ezh2 and not the de novo methyltransferase Dnmt3b.

Leseva M, Santostefano KE, Rosenbluth AL, Hamazaki T, Terada N.

Epigenetics. 2013 Aug;8(8):873-84. doi: 10.4161/epi.25522. Epub 2013 Jul 2.

9.

Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells.

Banaszynski LA, Wen D, Dewell S, Whitcomb SJ, Lin M, Diaz N, Elsässer SJ, Chapgier A, Goldberg AD, Canaani E, Rafii S, Zheng D, Allis CD.

Cell. 2013 Sep 26;155(1):107-20. doi: 10.1016/j.cell.2013.08.061.

10.

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.

Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF.

PLoS Genet. 2012;8(3):e1002576. doi: 10.1371/journal.pgen.1002576. Epub 2012 Mar 15.

11.

TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues.

Neri F, Incarnato D, Krepelova A, Dettori D, Rapelli S, Maldotti M, Parlato C, Anselmi F, Galvagni F, Oliviero S.

Nucleic Acids Res. 2015 Aug 18;43(14):6814-26. doi: 10.1093/nar/gkv392. Epub 2015 Apr 29.

12.

Promiscuous RNA binding by Polycomb repressive complex 2.

Davidovich C, Zheng L, Goodrich KJ, Cech TR.

Nat Struct Mol Biol. 2013 Nov;20(11):1250-7. doi: 10.1038/nsmb.2679. Epub 2013 Sep 29.

13.

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.

Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA.

Cell. 2016 Jun 2;165(6):1389-1400. doi: 10.1016/j.cell.2016.04.031. Epub 2016 May 19.

14.

BRCA1 is a negative modulator of the PRC2 complex.

Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H.

EMBO J. 2013 May 29;32(11):1584-97. doi: 10.1038/emboj.2013.95. Epub 2013 Apr 26.

15.

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.

Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP.

Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18.

PMID:
23160351
16.

RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes.

Wei C, Xiao R, Chen L, Cui H, Zhou Y, Xue Y, Hu J, Zhou B, Tsutsui T, Qiu J, Li H, Tang L, Fu XD.

Mol Cell. 2016 Jun 16;62(6):875-889. doi: 10.1016/j.molcel.2016.04.013. Epub 2016 May 19.

17.

SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells.

Fei Q, Yang X, Jiang H, Wang Q, Yu Y, Yu Y, Yi W, Zhou S, Chen T, Lu C, Atadja P, Liu XS, Li E, Zhang Y, Shou J.

Genome Res. 2015 Sep;25(9):1325-35. doi: 10.1101/gr.177576.114. Epub 2015 Jul 9.

18.

Polycomb recruitment at the Class II transactivator gene.

Boyd NH, Morgan JE, Greer SF.

Mol Immunol. 2015 Oct;67(2 Pt B):482-91. doi: 10.1016/j.molimm.2015.08.003. Epub 2015 Aug 15.

PMID:
26283540
19.

The interaction of PRC2 with RNA or chromatin is mutually antagonistic.

Beltran M, Yates CM, Skalska L, Dawson M, Reis FP, Viiri K, Fisher CL, Sibley CR, Foster BM, Bartke T, Ule J, Jenner RG.

Genome Res. 2016 Jul;26(7):896-907. doi: 10.1101/gr.197632.115. Epub 2016 May 9.

20.

Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin.

Kaneko S, Bonasio R, Saldaña-Meyer R, Yoshida T, Son J, Nishino K, Umezawa A, Reinberg D.

Mol Cell. 2014 Jan 23;53(2):290-300. doi: 10.1016/j.molcel.2013.11.012. Epub 2013 Dec 26.

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