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Items: 1 to 20 of 136

1.

The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling.

Tibaldi E, Zonta F, Bordin L, Magrin E, Gringeri E, Cillo U, Idotta G, Pagano MA, Brunati AM.

Biochim Biophys Acta. 2014 Feb;1843(2):288-98. doi: 10.1016/j.bbamcr.2013.10.010. Epub 2013 Oct 18.

2.

PDGF-D signaling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β.

Borkham-Kamphorst E, Meurer SK, Van de Leur E, Haas U, Tihaa L, Weiskirchen R.

Cell Signal. 2015 Jul;27(7):1305-14. doi: 10.1016/j.cellsig.2015.03.012. Epub 2015 Mar 27.

PMID:
25819339
3.

Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration.

Qi JH, Ito N, Claesson-Welsh L.

J Biol Chem. 1999 May 14;274(20):14455-63.

4.
5.

Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes.

Artemenko Y, Gagnon A, Sorisky A.

J Cell Physiol. 2009 Jan;218(1):228-36. doi: 10.1002/jcp.21595.

PMID:
18814181
6.

Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate.

Kim Y, Fiel MI, Albanis E, Chou HI, Zhang W, Khitrov G, Friedman SL.

Liver Int. 2012 Jul;32(6):1008-17. doi: 10.1111/j.1478-3231.2012.02806.x. Epub 2012 Apr 16.

8.
9.

TGF-β1 up-regulates the expression of PDGF-β receptor mRNA and induces a delayed PI3K-, AKT-, and p70(S6K) -dependent proliferative response in activated hepatic stellate cells.

Shah R, Reyes-Gordillo K, Arellanes-Robledo J, Lechuga CG, Hernández-Nazara Z, Cotty A, Rojkind M, Lakshman MR.

Alcohol Clin Exp Res. 2013 Nov;37(11):1838-48. doi: 10.1111/acer.12167. Epub 2013 Jul 29.

PMID:
23895226
10.

PDGF receptor-α promotes TGF-β signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-β receptors.

Liu C, Li J, Xiang X, Guo L, Tu K, Liu Q, Shah VH, Kang N.

Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1;307(7):G749-59. doi: 10.1152/ajpgi.00138.2014. Epub 2014 Aug 28.

11.

SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.

Rönnstrand L, Arvidsson AK, Kallin A, Rorsman C, Hellman U, Engström U, Wernstedt C, Heldin CH.

Oncogene. 1999 Jun 24;18(25):3696-702.

12.

Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology.

Nakata S, Fujita N, Kitagawa Y, Okamoto R, Ogita H, Takai Y.

J Biol Chem. 2007 Dec 28;282(52):37815-25. Epub 2007 Oct 30.

14.

HBV promotes the proliferation of hepatic stellate cells via the PDGF-B/PDGFR-β signaling pathway in vitro.

Bai Q, An J, Wu X, You H, Ma H, Liu T, Gao N, Jia J.

Int J Mol Med. 2012 Dec;30(6):1443-50. doi: 10.3892/ijmm.2012.1148. Epub 2012 Oct 4.

PMID:
23042547
15.

Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells.

Dong Y, Jia L, Wang X, Tan X, Xu J, Deng Z, Jiang T, Rainov NG, Li B, Ren H.

Int J Oncol. 2011 Feb;38(2):555-69. doi: 10.3892/ijo.2010.861. Epub 2010 Dec 6.

PMID:
21152856
16.

Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor.

Tsai TH, Shih SC, Ho TC, Ma HI, Liu MY, Chen SL, Tsao YP.

PLoS One. 2014 Apr 24;9(4):e95443. doi: 10.1371/journal.pone.0095443. eCollection 2014. Erratum in: PLoS One. 2014;9(9): doi/10.1371/journal.pone.0108835.

17.

Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells.

Kinoshita K, Nakagawa K, Hamada J, Hida Y, Tada M, Kondo S, Moriuchi T.

Int J Oncol. 2010 Oct;37(4):869-77.

PMID:
20811709
18.

Depletion of β-arrestin2 in hepatic stellate cells reduces cell proliferation via ERK pathway.

Sun WY, Song Y, Hu SS, Wang QT, Wu HX, Chen JY, Wei W.

J Cell Biochem. 2013 May;114(5):1153-62. doi: 10.1002/jcb.24458.

PMID:
23192415
19.

TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways.

Fang L, Zhan S, Huang C, Cheng X, Lv X, Si H, Li J.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):713-25. doi: 10.1016/j.taap.2013.08.009. Epub 2013 Aug 16.

PMID:
23958495
20.

Peroxisome proliferator-activated receptor-γ interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-β receptor in hepatic stellate cells.

Zhang F, Kong D, Chen L, Zhang X, Lian N, Zhu X, Lu Y, Zheng S.

J Cell Sci. 2014 Jan 15;127(Pt 2):305-14. doi: 10.1242/jcs.128306. Epub 2013 Nov 20.

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