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NF-κB: a coordinator for epigenetic regulation by MLL.

Goyama S, Mulloy JC.

Cancer Cell. 2013 Oct 14;24(4):401-2. doi: 10.1016/j.ccr.2013.09.016.


Epigenetic roles of MLL oncoproteins are dependent on NF-κB.

Kuo HP, Wang Z, Lee DF, Iwasaki M, Duque-Afonso J, Wong SH, Lin CH, Figueroa ME, Su J, Lemischka IR, Cleary ML.

Cancer Cell. 2013 Oct 14;24(4):423-37. doi: 10.1016/j.ccr.2013.08.019. Epub 2013 Sep 19.


Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.

Zeisig BB, Cheung N, Yeung J, So CW.

Cancer Cell. 2008 Nov 4;14(5):345-7. doi: 10.1016/j.ccr.2008.10.008.


DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA.

Nat Med. 2015 Apr;21(4):335-43. doi: 10.1038/nm.3832. Epub 2015 Mar 30.


Harnessing gene repression to inhibit leukemia.

Harte PJ, Ernst P.

Nat Med. 2015 Apr;21(4):308-10. doi: 10.1038/nm.3834. No abstract available.


MLL translocations, histone modifications and leukaemia stem-cell development.

Krivtsov AV, Armstrong SA.

Nat Rev Cancer. 2007 Nov;7(11):823-33. Review.


The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.

Wong SH, Goode DL, Iwasaki M, Wei MC, Kuo HP, Zhu L, Schneidawind D, Duque-Afonso J, Weng Z, Cleary ML.

Cancer Cell. 2015 Aug 10;28(2):198-209. doi: 10.1016/j.ccell.2015.06.003. Epub 2015 Jul 16.


An MLL-dependent network sustains hematopoiesis.

Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EK, Moore AW, Chen Y, Cheng C, Ernst P.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12000-5. doi: 10.1073/pnas.1301278110. Epub 2013 Jun 6.


When epigenetics kills: MLL fusion proteins in leukemia.

Slany RK.

Hematol Oncol. 2005 Mar;23(1):1-9. Review.


Targeting epigenetic programs in MLL-rearranged leukemias.

Bernt KM, Armstrong SA.

Hematology Am Soc Hematol Educ Program. 2011;2011:354-60. doi: 10.1182/asheducation-2011.1.354. Review.


RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes.

Koh CP, Wang CQ, Ng CE, Ito Y, Araki M, Tergaonkar V, Huang G, Osato M.

Leukemia. 2013 Sep;27(9):1793-802. doi: 10.1038/leu.2013.200. Epub 2013 Jul 2. Review.


Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells.

Luc S, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11670-1. doi: 10.1073/pnas.1310349110. Epub 2013 Jul 3. No abstract available.


Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.

Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J.

Cancer Cell. 2012 Oct 16;22(4):524-35. doi: 10.1016/j.ccr.2012.08.028.


MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.

Wu M, Shu HB.

Chin J Cancer. 2011 Apr;30(4):240-6. Review.


Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.

Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, Kobayashi H, Saito T, Iwakura Y, Kurokawa M.

J Clin Invest. 2014 Feb;124(2):528-42. doi: 10.1172/JCI68101. Epub 2014 Jan 2.


Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.

Paggetti J, Largeot A, Aucagne R, Jacquel A, Lagrange B, Yang XJ, Solary E, Bastie JN, Delva L.

Oncogene. 2010 Sep 9;29(36):5019-31. doi: 10.1038/onc.2010.254. Epub 2010 Jun 28.


Linking MLL and the HGF-MET signaling pathway in liver cancer.

Marquardt JU, Thorgeirsson SS.

J Clin Invest. 2013 Jul;123(7):2780-3. doi: 10.1172/JCI70235. Epub 2013 Jun 24.


Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.

Aikawa Y, Yamagata K, Katsumoto T, Shima Y, Shino M, Stanley ER, Cleary ML, Akashi K, Tenen DG, Kitabayashi I.

Cancer Sci. 2015 Mar;106(3):227-36. doi: 10.1111/cas.12593. Epub 2015 Feb 12.


Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells.

Arai S, Yoshimi A, Shimabe M, Ichikawa M, Nakagawa M, Imai Y, Goyama S, Kurokawa M.

Blood. 2011 Jun 9;117(23):6304-14. doi: 10.1182/blood-2009-07-234310. Epub 2010 Dec 29.


Linking MLL Leukemia with Integrin Signaling.

Zeisig BB, So CW.

Cancer Cell. 2013 Jul 8;24(1):5-7. doi: 10.1016/j.ccr.2013.06.011.

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