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AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.

Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K.

J Clin Invest. 2013 Nov;123(11):4888-99. doi: 10.1172/JCI66218.


Mitochondrial hormesis and diabetic complications.

Sharma K.

Diabetes. 2015 Mar;64(3):663-72. doi: 10.2337/db14-0874. Review.


RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, Brownlee M, Bierhaus A, Cooper ME, Forbes JM.

J Am Soc Nephrol. 2009 Apr;20(4):742-52. doi: 10.1681/ASN.2008050514.


Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation.

Qiang G, Yang X, Shi L, Zhang H, Chen B, Zhao Y, Zu M, Zhou D, Guo J, Yang H, Zhang L, Du G.

Cell Physiol Biochem. 2015;36(1):395-408. doi: 10.1159/000430258.


Mitochondrial superoxide and coenzyme Q in insulin-deficient rats: increased electron leak.

Herlein JA, Fink BD, Henry DM, Yorek MA, Teesch LM, Sivitz WI.

Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1616-24. doi: 10.1152/ajpregu.00395.2011.


Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications.

Nishikawa T, Araki E.

Antioxid Redox Signal. 2007 Mar;9(3):343-53. Review.


C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes.

Bhatt MP, Lim YC, Kim YM, Ha KS.

Diabetes. 2013 Nov;62(11):3851-62. doi: 10.2337/db13-0039.


Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats.

Matsuoka T, Wada J, Hashimoto I, Zhang Y, Eguchi J, Ogawa N, Shikata K, Kanwar YS, Makino H.

Diabetes. 2005 Oct;54(10):2882-90.


Rac1 is required for cardiomyocyte apoptosis during hyperglycemia.

Shen E, Li Y, Li Y, Shan L, Zhu H, Feng Q, Arnold JM, Peng T.

Diabetes. 2009 Oct;58(10):2386-95. doi: 10.2337/db08-0617.


Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.

Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF.

Am J Physiol Renal Physiol. 2005 Aug;289(2):F420-30.


Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation.

Li L, Chen Y, Gibson SB.

Cell Signal. 2013 Jan;25(1):50-65. doi: 10.1016/j.cellsig.2012.09.020.


AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes.

Wang XR, Zhang MW, Chen DD, Zhang Y, Chen AF.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1135-45. doi: 10.1152/ajpendo.00001.2011.


Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis.

Mohamed R, Jayakumar C, Chen F, Fulton D, Stepp D, Gansevoort RT, Ramesh G.

J Am Soc Nephrol. 2016 Mar;27(3):745-65. doi: 10.1681/ASN.2014111136.


Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.

Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P.

Diabetes. 2011 Jan;60(1):288-97. doi: 10.2337/db10-0818.


Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells.

Munusamy S, MacMillan-Crow LA.

Free Radic Biol Med. 2009 Apr 15;46(8):1149-57. doi: 10.1016/j.freeradbiomed.2009.01.022.


Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells.

Babu D, Leclercq G, Goossens V, Vanden Berghe T, Van Hamme E, Vandenabeele P, Lefebvre RA.

Cell Signal. 2015 Jun;27(6):1141-58. doi: 10.1016/j.cellsig.2015.02.019.


Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression.

Eid AA, Lee DY, Roman LJ, Khazim K, Gorin Y.

Mol Cell Biol. 2013 Sep;33(17):3439-60. doi: 10.1128/MCB.00217-13.


Mitochondrial biogenesis: pharmacological approaches.

Valero T.

Curr Pharm Des. 2014;20(35):5507-9.


Reactive oxygen species enhances endothelin-1 production of diabetic rat glomeruli in vitro and in vivo.

Chen HC, Guh JY, Shin SJ, Tsai JH, Lai YH.

J Lab Clin Med. 2000 Apr;135(4):309-15.

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