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Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells.

Christou YA, Ohyama K, Placzek M, Monk PN, Shaw PJ.

BMC Neurosci. 2013 Oct 17;14:126. doi: 10.1186/1471-2202-14-126.


Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.

Cell Stem Cell. 2008 Dec 4;3(6):649-57. doi: 10.1016/j.stem.2008.10.001.


Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.

Nat Neurosci. 2007 May;10(5):615-22. Epub 2007 Apr 15.


Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.

Fontanilla CV, Gu H, Liu Q, Zhu TZ, Zhou C, Johnstone BH, March KL, Pascuzzi RM, Farlow MR, Du Y.

Sci Rep. 2015 Nov 20;5:16953. doi: 10.1038/srep16953. Erratum in: Sci Rep. 2016;6:20747.


GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN.

PLoS One. 2007 Aug 1;2(8):e689.


Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis.

Pehar M, Cassina P, Vargas MR, Castellanos R, Viera L, Beckman JS, Estévez AG, Barbeito L.

J Neurochem. 2004 Apr;89(2):464-73.


Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.

Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K.

Stem Cells Transl Med. 2012 May;1(5):396-402. doi: 10.5966/sctm.2011-0061. Epub 2012 May 8.


Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.

Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M.

Dis Model Mech. 2009 Mar-Apr;2(3-4):189-95. doi: 10.1242/dmm.002113. Epub 2009 Feb 23.


Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice.

Ma X, Turnbull P, Peterson R, Turnbull J.

BMC Neurosci. 2013 Oct 11;14:119. doi: 10.1186/1471-2202-14-119.


Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

Papadeas ST, Kraig SE, O'Banion C, Lepore AC, Maragakis NJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17803-8. doi: 10.1073/pnas.1103141108. Epub 2011 Oct 3.


Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

Miquel E, Cassina A, Martínez-Palma L, Bolatto C, Trías E, Gandelman M, Radi R, Barbeito L, Cassina P.

PLoS One. 2012;7(4):e34776. doi: 10.1371/journal.pone.0034776. Epub 2012 Apr 3.


Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice.

Pardo AC, Wong V, Benson LM, Dykes M, Tanaka K, Rothstein JD, Maragakis NJ.

Exp Neurol. 2006 Sep;201(1):120-30. Epub 2006 Jun 6.


Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis.

Benkler C, Ben-Zur T, Barhum Y, Offen D.

Glia. 2013 Mar;61(3):312-26. doi: 10.1002/glia.22428. Epub 2012 Dec 22.


Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.

Nat Biotechnol. 2011 Aug 10;29(9):824-8. doi: 10.1038/nbt.1957.


Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.

Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ.

PLoS One. 2011;6(10):e25968. doi: 10.1371/journal.pone.0025968. Epub 2011 Oct 5.


Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells.

López-González R, Kunckles P, Velasco I.

Cell Transplant. 2009;18(10):1171-81. doi: 10.3727/096368909X12483162197123. Epub 2009 Aug 5.


Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC.

Cell Stem Cell. 2008 Dec 4;3(6):637-48. doi: 10.1016/j.stem.2008.09.017.


The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes.

König HG, Coughlan KS, Kinsella S, Breen BA, Prehn JH.

Neurobiol Dis. 2014 Oct;70:99-107. doi: 10.1016/j.nbd.2014.06.008. Epub 2014 Jun 21.


Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, Rossi PI, Vergani L, Voci A, Conti F, Puliti A, Bonanno G.

Neurobiol Dis. 2014 Apr;64:48-59. doi: 10.1016/j.nbd.2013.11.006. Epub 2013 Dec 19.

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