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Restoration of self-awareness of hypoglycemia in adults with long-standing type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial.

Leelarathna L, Little SA, Walkinshaw E, Tan HK, Lubina-Solomon A, Kumareswaran K, Lane AP, Chadwick T, Marshall SM, Speight J, Flanagan D, Heller SR, Shaw JA, Evans ML.

Diabetes Care. 2013 Dec;36(12):4063-70. doi: 10.2337/dc13-1004.


Recovery of hypoglycemia awareness in long-standing type 1 diabetes: a multicenter 2 × 2 factorial randomized controlled trial comparing insulin pump with multiple daily injections and continuous with conventional glucose self-monitoring (HypoCOMPaSS).

Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JA.

Diabetes Care. 2014 Aug;37(8):2114-22. doi: 10.2337/dc14-0030.


Blood glucose awareness training and epinephrine responses to hypoglycemia during intensive treatment in type 1 diabetes.

Kinsley BT, Weinger K, Bajaj M, Levy CJ, Simonson DC, Quigley M, Cox DJ, Jacobson AM.

Diabetes Care. 1999 Jul;22(7):1022-8.


Real-time continuous glucose monitoring significantly reduces severe hypoglycemia in hypoglycemia-unaware patients with type 1 diabetes.

Choudhary P, Ramasamy S, Green L, Gallen G, Pender S, Brackenridge A, Amiel SA, Pickup JC.

Diabetes Care. 2013 Dec;36(12):4160-2. doi: 10.2337/dc13-0939.


Effects of glycemic control on protective responses against hypoglycemia in type 2 diabetes.

Korzon-Burakowska A, Hopkins D, Matyka K, Lomas J, Pernet A, Macdonald I, Amiel S.

Diabetes Care. 1998 Feb;21(2):283-90.


Interventions That Restore Awareness of Hypoglycemia in Adults With Type 1 Diabetes: A Systematic Review and Meta-analysis.

Yeoh E, Choudhary P, Nwokolo M, Ayis S, Amiel SA.

Diabetes Care. 2015 Aug;38(8):1592-609. doi: 10.2337/dc15-0102. Review.


Counterregulatory hormone responses after long-term continuous subcutaneous insulin infusion with lispro insulin.

Tsui EY, Chiasson JL, Tildesley H, Barnie A, Simkins S, Strack T, Zinman B.

Diabetes Care. 1998 Jan;21(1):93-6.


Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: A randomized clinical trial.

Moheet A, Mangia S, Kumar A, Tesfaye N, Eberly LE, Bai Y, Kubisiak K, Seaquist ER.

J Diabetes Complications. 2015 Nov-Dec;29(8):1277-82. doi: 10.1016/j.jdiacomp.2015.08.004.


Design and rationale of the IN CONTROL trial: the effects of real-time continuous glucose monitoring on glycemia and quality of life in patients with type 1 diabetes mellitus and impaired awareness of hypoglycemia.

van Beers CA, Kleijer SJ, Serné EH, Geelhoed-Duijvestijn PH, Snoek FJ, Kramer MH, Diamant M.

BMC Endocr Disord. 2015 Aug 21;15:42. doi: 10.1186/s12902-015-0040-3.


Does the timing of insulin pump therapy initiation after type 1 diabetes onset have an impact on glycemic control?

Shalitin S, Lahav-Ritte T, Lebenthal Y, Devries L, Phillip M.

Diabetes Technol Ther. 2012 May;14(5):389-97. doi: 10.1089/dia.2011.0267.


Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes.

Fritsche A, Stefan N, Häring H, Gerich J, Stumvoll M.

Ann Intern Med. 2001 May 1;134(9 Pt 1):729-36.


Safety, efficacy and glucose turnover of reduced prandial boluses during closed-loop therapy in adolescents with type 1 diabetes: a randomized clinical trial.

Elleri D, Biagioni M, Allen JM, Kumareswaran K, Leelarathna L, Caldwell K, Nodale M, Wilinska ME, Haidar A, Calhoun P, Kollman C, Jackson NC, Umpleby AM, Acerini CL, Dunger DB, Hovorka R.

Diabetes Obes Metab. 2015 Dec;17(12):1173-9. doi: 10.1111/dom.12549.


Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes.

Farngren J, Persson M, Schweizer A, Foley JE, Ahrén B.

J Clin Endocrinol Metab. 2012 Oct;97(10):3799-806. doi: 10.1210/jc.2012-2332.


Sensor-augmented insulin pump therapy: results of the first randomized treat-to-target study.

Hirsch IB, Abelseth J, Bode BW, Fischer JS, Kaufman FR, Mastrototaro J, Parkin CG, Wolpert HA, Buckingham BA.

Diabetes Technol Ther. 2008 Oct;10(5):377-83. doi: 10.1089/dia.2008.0068.


Improvement of impaired counterregulatory hormone response and symptom perception by short-term avoidance of hypoglycemia in IDDM.

Lingenfelser T, Buettner U, Martin J, Tobis M, Renn W, Kaschel R, Jakober B.

Diabetes Care. 1995 Mar;18(3):321-5.


Prolonged nocturnal hypoglycemia is common during 12 months of continuous glucose monitoring in children and adults with type 1 diabetes.

Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group..

Diabetes Care. 2010 May;33(5):1004-8. doi: 10.2337/dc09-2081.


Achievement of target A1C levels with negligible hypoglycemia and low glucose variability in youth with short-term type 1 diabetes and residual β-cell function.

Sherr J, Tamborlane WV, Xing D, Tsalikian E, Mauras N, Buckingham B, White NH, Arbelaez AM, Beck RW, Kollman C, Ruedy K; Diabetes Research in Children Network (DirecNet) Study Group..

Diabetes Care. 2012 Apr;35(4):817-20. doi: 10.2337/dc11-2190.

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