Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 145


Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.

Maede Y, Shimizu H, Fukushima T, Kogame T, Nakamura T, Miki T, Takeda S, Pommier Y, Murai J.

Mol Cancer Ther. 2014 Jan;13(1):214-20. doi: 10.1158/1535-7163.MCT-13-0551. Epub 2013 Oct 15.


Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.

Adachi N, Iiizumi S, So S, Koyama H.

Biochem Biophys Res Commun. 2004 Jun 11;318(4):856-61.


TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.


Roles of nonhomologous end-joining pathways in surviving topoisomerase II-mediated DNA damage.

Malik M, Nitiss KC, Enriquez-Rios V, Nitiss JL.

Mol Cancer Ther. 2006 Jun;5(6):1405-14.


TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F.

PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7.


Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

Nitiss KC, Malik M, He X, White SW, Nitiss JL.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8953-8. Epub 2006 Jun 2.


Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination.

de Campos-Nebel M, Larripa I, González-Cid M.

PLoS One. 2010 Sep 2;5(9). pii: e12541. doi: 10.1371/journal.pone.0012541.


Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.

Kont YS, Dutta A, Mallisetty A, Mathew J, Minas T, Kraus C, Dhopeshwarkar P, Kallakury B, Mitra S, Üren A, Adhikari S.

DNA Repair (Amst). 2016 Jul;43:38-47. doi: 10.1016/j.dnarep.2016.04.009. Epub 2016 May 7.


Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C.

DNA Repair (Amst). 2014 Jul;19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. Review.


Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy.

Xu Y, Her C.

Biomolecules. 2015 Jul 22;5(3):1652-70. doi: 10.3390/biom5031652. Review.


Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors.

Tomicic MT, Kaina B.

Biochim Biophys Acta. 2013 Jan;1835(1):11-27. doi: 10.1016/j.bbcan.2012.09.002. Epub 2012 Sep 21. Review.


DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

Cristini A, Park JH, Capranico G, Legube G, Favre G, Sordet O.

Nucleic Acids Res. 2016 Feb 18;44(3):1161-78. doi: 10.1093/nar/gkv1196. Epub 2015 Nov 17.


FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.

Kametani Y, Takahata C, Narita T, Tanaka K, Iwai S, Kuraoka I.

Carcinogenesis. 2016 Jan;37(1):56-62. doi: 10.1093/carcin/bgv159. Epub 2015 Nov 17.


Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.

Vance JR, Wilson TE.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13669-74. Epub 2002 Oct 4.


NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.

Toyoda E, Kagaya S, Cowell IG, Kurosawa A, Kamoshita K, Nishikawa K, Iiizumi S, Koyama H, Austin CA, Adachi N.

J Biol Chem. 2008 Aug 29;283(35):23711-20. doi: 10.1074/jbc.M803936200. Epub 2008 Jul 2.


Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.

Jensen NF, Agama K, Roy A, Smith DH, Pfister TD, Rømer MU, Zhang HL, Doroshow JH, Knudsen BR, Stenvang J, Brünner N, Pommier Y.

J Exp Clin Cancer Res. 2016 Mar 31;35:56. doi: 10.1186/s13046-016-0335-x.


Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.

Trinh BQ, Ko SY, Barengo N, Lin SY, Naora H.

Cancer Res. 2013 Jan 15;73(2):1000-10. doi: 10.1158/0008-5472.CAN-12-3538. Epub 2012 Dec 7.


The requirement of Artemis in double-strand break repair depends on the type of DNA damage.

Kurosawa A, Koyama H, Takayama S, Miki K, Ayusawa D, Fujii M, Iiizumi S, Adachi N.

DNA Cell Biol. 2008 Jan;27(1):55-61.


Supplemental Content

Support Center