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Items: 1 to 20 of 115

1.

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation.

Hay DL, Harris PW, Kowalczyk R, Brimble MA, Rathbone DL, Barwell J, Conner AC, Poyner DR.

Br J Pharmacol. 2014 Jan;171(2):415-26. doi: 10.1111/bph.12464.

2.

Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding.

Banerjee S, Evanson J, Harris E, Lowe SL, Thomasson KA, Porter JE.

BMC Pharmacol. 2006 Jun 15;6:9.

3.

Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity.

Smith DD, Saha S, Fang G, Schaffert C, Waugh DJ, Zeng W, Toth G, Hulce M, Abel PW.

J Med Chem. 2003 Jun 5;46(12):2427-35.

PMID:
12773046
4.

Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin.

Uezono Y, Nakamura E, Ueda Y, Shibuya I, Ueta Y, Yokoo H, Yanagita T, Toyohira Y, Kobayashi H, Yanagihara N, Wada A.

Brain Res Mol Brain Res. 2001 Dec 16;97(1):59-69.

PMID:
11744163
5.

Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.

Qi T, Christopoulos G, Bailey RJ, Christopoulos A, Sexton PM, Hay DL.

Mol Pharmacol. 2008 Oct;74(4):1059-71. doi: 10.1124/mol.108.047142. Epub 2008 Jul 1.

6.

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor.

Barwell J, Miller PS, Donnelly D, Poyner DR.

Peptides. 2010 Jan;31(1):170-6. doi: 10.1016/j.peptides.2009.10.021. Epub 2009 Nov 11.

7.

Turn structures in CGRP C-terminal analogues promote stable arrangements of key residue side chains.

Carpenter KA, Schmidt R, von Mentzer B, Haglund U, Roberts E, Walpole C.

Biochemistry. 2001 Jul 27;40(28):8317-25.

PMID:
11444978
8.
10.

Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor.

Lang M, De Pol S, Baldauf C, Hofmann HJ, Reiser O, Beck-Sickinger AG.

J Med Chem. 2006 Jan 26;49(2):616-24.

PMID:
16420047
11.

Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.

Pin SS, Xu C, Bahr BA.

Eur J Pharmacol. 2007 Dec 22;577(1-3):7-16. Epub 2007 Aug 17.

PMID:
17825280
12.

G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide.

Meens MJ, Mattheij NJ, van Loenen PB, Spijkers LJ, Lemkens P, Nelissen J, Compeer MG, Alewijnse AE, De Mey JG.

Br J Pharmacol. 2012 May;166(1):297-308. doi: 10.1111/j.1476-5381.2011.01774.x.

13.
14.

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.

Watkins HA, Walker CS, Ly KN, Bailey RJ, Barwell J, Poyner DR, Hay DL.

Br J Pharmacol. 2014 Feb;171(3):772-88. doi: 10.1111/bph.12508.

15.

Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor.

Koller D, Ittner LM, Muff R, Husmann K, Fischer JA, Born W.

J Biol Chem. 2004 May 7;279(19):20387-91. Epub 2004 Mar 8.

16.

Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors.

Qi T, Ly K, Poyner DR, Christopoulos G, Sexton PM, Hay DL.

Peptides. 2011 May;32(5):1060-7. doi: 10.1016/j.peptides.2011.03.004. Epub 2011 Mar 22.

PMID:
21402116
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