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Items: 1 to 20 of 156


Factor XI anion-binding sites are required for productive interactions with polyphosphate.

Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D.

J Thromb Haemost. 2013 Nov;11(11):2020-8. doi: 10.1111/jth.12414.


Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.

Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ.

J Thromb Haemost. 2013 Jul;11(7):1341-52. doi: 10.1111/jth.12295.


Evidence for factor IX-independent roles for factor XIa in blood coagulation.

Matafonov A, Cheng Q, Geng Y, Verhamme IM, Umunakwe O, Tucker EI, Sun MF, Serebrov V, Gruber A, Gailani D.

J Thromb Haemost. 2013 Dec;11(12):2118-27. doi: 10.1111/jth.12435.


Characterization of a heparin binding site on the heavy chain of factor XI.

Zhao M, Abdel-Razek T, Sun MF, Gailani D.

J Biol Chem. 1998 Nov 20;273(47):31153-9.


The mechanism underlying activation of factor IX by factor XIa.

Gailani D, Geng Y, Verhamme I, Sun MF, Bajaj SP, Messer A, Emsley J.

Thromb Res. 2014 May;133 Suppl 1:S48-51. doi: 10.1016/j.thromres.2014.03.020. Review.


Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.

Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D.

J Thromb Haemost. 2013 Jul;11(7):1374-84. doi: 10.1111/jth.12275.


Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation.

Zivelin A, Ogawa T, Bulvik S, Landau M, Toomey JR, Lane J, Seligsohn U, Gailani D.

J Thromb Haemost. 2004 Oct;2(10):1782-9.


The dimeric structure of factor XI and zymogen activation.

Geng Y, Verhamme IM, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, Gailani D.

Blood. 2013 May 9;121(19):3962-9. doi: 10.1182/blood-2012-12-473629. Epub 2013 Mar 20.


Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa.

Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN.

J Biol Chem. 2008 Jul 4;283(27):18655-64. doi: 10.1074/jbc.M802275200. Epub 2008 Apr 25.


Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential.

Gailani D, Ho D, Sun MF, Cheng Q, Walsh PN.

Blood. 2001 May 15;97(10):3117-22.


Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.

Puy C, Tucker EI, Ivanov IS, Gailani D, Smith SA, Morrissey JH, Gruber A, McCarty OJ.

PLoS One. 2016 Oct 20;11(10):e0165172. doi: 10.1371/journal.pone.0165172. eCollection 2016.


Structural and functional features of factor XI.

Gailani D, Smith SB.

J Thromb Haemost. 2009 Jul;7 Suppl 1:75-8. doi: 10.1111/j.1538-7836.2009.03414.x. Review.


FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow.

Zhu S, Travers RJ, Morrissey JH, Diamond SL.

Blood. 2015 Sep 17;126(12):1494-502. doi: 10.1182/blood-2015-04-641472. Epub 2015 Jul 1.


A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect.

Gailani D, Schmidt A, Sun MF, Bolton-Maggs PH, Bajaj SP.

J Thromb Haemost. 2007 Apr;5(4):781-7. Epub 2007 Jan 9.


Structure and function of factor XI.

Emsley J, McEwan PA, Gailani D.

Blood. 2010 Apr 1;115(13):2569-77. doi: 10.1182/blood-2009-09-199182. Epub 2010 Jan 28. Review.


Activation of factor XI by products of prothrombin activation.

Matafonov A, Sarilla S, Sun MF, Sheehan JP, Serebrov V, Verhamme IM, Gailani D.

Blood. 2011 Jul 14;118(2):437-45. doi: 10.1182/blood-2010-10-312983. Epub 2011 Apr 28.


Naturally occurring human antibodies against two distinct functional domains in the heavy chain of FXI/FXIa.

De La Cadena RA, Baglia FA, Johnson CA, Wenk RE, Amernick R, Walsh PN, Colman RW.

Blood. 1988 Nov;72(5):1748-54.


Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI.

Baglia FA, Gailani D, López JA, Walsh PN.

J Biol Chem. 2004 Oct 29;279(44):45470-6. Epub 2004 Aug 17.


Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia.

Minnema MC, Pajkrt D, Wuillemin WA, Roem D, Bleeker WK, Levi M, van Deventer SJ, Hack CE, ten Cate H.

Blood. 1998 Nov 1;92(9):3294-301.


Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein.

Renné T, Gailani D, Meijers JC, Müller-Esterl W.

J Biol Chem. 2002 Feb 15;277(7):4892-9. Epub 2001 Nov 30.

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