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Items: 1 to 20 of 96

1.

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase.

Wang C, Chang WC, Guo Y, Huang H, Peck SC, Pandelia ME, Lin GM, Liu HW, Krebs C, Bollinger JM Jr.

Science. 2013 Nov 22;342(6161):991-5. doi: 10.1126/science.1240373. Epub 2013 Oct 10.

2.

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.

Chang WC, Dey M, Liu P, Mansoorabadi SO, Moon SJ, Zhao ZK, Drennan CL, Liu HW.

Nature. 2013 Apr 4;496(7443):114-8. doi: 10.1038/nature11998.

3.
4.

Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae.

Munos JW, Moon SJ, Mansoorabadi SO, Chang W, Hong L, Yan F, Liu A, Liu HW.

Biochemistry. 2008 Aug 19;47(33):8726-35. doi: 10.1021/bi800877v. Epub 2008 Jul 26.

5.

Biochemistry. Not an oxidase, but a peroxidase.

Raushel FM.

Science. 2013 Nov 22;342(6161):943-4. doi: 10.1126/science.1247233. No abstract available.

PMID:
24264984
6.

Mechanistic consequences of chiral radical clock probes: analysis of the mononuclear non-heme iron enzyme HppE with 2-hydroxy-3-methylenecyclopropyl radical clock substrates.

Huang H, Chang WC, Lin GM, Romo A, Pai PJ, Russell WK, Russell DH, Liu HW.

J Am Chem Soc. 2014 Feb 26;136(8):2944-7. doi: 10.1021/ja4100035. Epub 2014 Feb 13.

7.

Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.

Yun D, Dey M, Higgins LJ, Yan F, Liu HW, Drennan CL.

J Am Chem Soc. 2011 Jul 27;133(29):11262-9. doi: 10.1021/ja2025728. Epub 2011 Jun 30.

8.
9.

Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme.

Liu P, Liu A, Yan F, Wolfe MD, Lipscomb JD, Liu HW.

Biochemistry. 2003 Oct 14;42(40):11577-86.

PMID:
14529267
10.

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase.

Yan F, Li T, Lipscomb JD, Liu A, Liu HW.

Arch Biochem Biophys. 2005 Oct 1;442(1):82-91.

PMID:
16150418
11.

Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis.

Liu P, Mehn MP, Yan F, Zhao Z, Que L Jr, Liu HW.

J Am Chem Soc. 2004 Aug 25;126(33):10306-12.

PMID:
15315444
12.

Evidence for radical-mediated catalysis by HppE: a study using cyclopropyl and methylenecyclopropyl substrate analogues.

Huang H, Chang WC, Pai PJ, Romo A, Mansoorabadi SO, Russell DH, Liu HW.

J Am Chem Soc. 2012 Oct 3;134(39):16171-4. doi: 10.1021/ja3078126. Epub 2012 Sep 24.

13.

Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism.

McLuskey K, Cameron S, Hammerschmidt F, Hunter WN.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14221-6. Epub 2005 Sep 26.

14.

Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement.

Chang WC, Mansoorabadi SO, Liu HW.

J Am Chem Soc. 2013 Jun 5;135(22):8153-6. doi: 10.1021/ja403441x. Epub 2013 May 23.

15.

On the catalytic mechanism of (S)-2-hydroxypropylphosphonic acid epoxidase (HppE): a hybrid DFT study.

MiƂaczewska A, Broclawik E, Borowski T.

Chemistry. 2013 Jan 7;19(2):771-81. doi: 10.1002/chem.201202825. Epub 2012 Nov 13.

PMID:
23150463
16.

Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin.

Liu P, Murakami K, Seki T, He X, Yeung SM, Kuzuyama T, Seto H, Liu H.

J Am Chem Soc. 2001 May 16;123(19):4619-20. No abstract available.

PMID:
11457256
17.

18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates.

Mirica LM, McCusker KP, Munos JW, Liu HW, Klinman JP.

J Am Chem Soc. 2008 Jul 2;130(26):8122-3. doi: 10.1021/ja800265s. Epub 2008 Jun 7.

18.

How do Enzymes Utilize Reactive OH Radicals? Lessons from Nonheme HppE and Fenton Systems.

Wang B, Lu J, Dubey KD, Dong G, Lai W, Shaik S.

J Am Chem Soc. 2016 Jul 13;138(27):8489-96. doi: 10.1021/jacs.6b03555. Epub 2016 Jul 1.

PMID:
27309496
19.
20.

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

Olivares P, Ulrich EC, Chekan JR, van der Donk WA, Nair SK.

ACS Chem Biol. 2017 Feb 17;12(2):456-463. doi: 10.1021/acschembio.6b00939. Epub 2016 Dec 27.

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