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Items: 1 to 20 of 60

1.

PU-H71 effectively induces degradation of IκB kinase β in the presence of TNF-α.

Qu Z, Wang S, Teng R, Yi X.

Mol Cell Biochem. 2014 Jan;386(1-2):135-42. doi: 10.1007/s11010-013-1852-y.

PMID:
24114662
2.
3.

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.

Usmani SZ, Bona RD, Chiosis G, Li Z.

J Hematol Oncol. 2010 Oct 26;3:40. doi: 10.1186/1756-8722-3-40.

4.

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma.

Ambati SR, Lopes EC, Kosugi K, Mony U, Zehir A, Shah SK, Taldone T, Moreira AL, Meyers PA, Chiosis G, Moore MA.

Mol Oncol. 2014 Mar;8(2):323-36. doi: 10.1016/j.molonc.2013.12.005.

5.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106.

6.

Combined effects of 17-DMAG and TNF on cells through a mechanism related to the NF-kappaB pathway.

Qu Z, Dong H, Xu X, Feng W, Yi X.

Diagn Pathol. 2013 May 1;8:70. doi: 10.1186/1746-1596-8-70.

7.

Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.

Segawa T, Fujii Y, Tanaka A, Bando S, Okayasu R, Ohnishi K, Kubota N.

Int J Mol Med. 2014 Mar;33(3):559-64. doi: 10.3892/ijmm.2013.1594.

PMID:
24366006
8.

Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.

Tse AK, Wan CK, Shen XL, Yang M, Fong WF.

Biochem Pharmacol. 2005 Nov 15;70(10):1443-57.

PMID:
16181613
9.

Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.

Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H.

J Immunol. 2011 Sep 1;187(5):2202-12. doi: 10.4049/jimmunol.1100285.

11.

Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation.

Tse AK, Wan CK, Zhu GY, Shen XL, Cheung HY, Yang M, Fong WF.

Mol Immunol. 2007 Apr;44(10):2647-58.

PMID:
17240450
12.

Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation.

Funakoshi-Tago M, Tanabe S, Tago K, Itoh H, Mashino T, Sonoda Y, Kasahara T.

Mol Pharmacol. 2009 Oct;76(4):745-53. doi: 10.1124/mol.109.057448.

13.

Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene.

Tanabe A, Konno J, Tanikawa K, Sahara H.

Gene. 2014 Feb 1;535(1):24-32. doi: 10.1016/j.gene.2013.11.005.

PMID:
24269672
14.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E.

Blood. 2013 Oct 17;122(16):2837-47. doi: 10.1182/blood-2013-01-479972.

15.

Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling.

Widera D, Mikenberg I, Elvers M, Kaltschmidt C, Kaltschmidt B.

BMC Neurosci. 2006 Sep 20;7:64.

16.

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.

Holland JP, Caldas-Lopes E, Divilov V, Longo VA, Taldone T, Zatorska D, Chiosis G, Lewis JS.

PLoS One. 2010 Jan 25;5(1):e8859. doi: 10.1371/journal.pone.0008859.

17.

Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.

Lora JM, Zhang DM, Liao SM, Burwell T, King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, Gutiérrez-Ramos JC, Coyle AJ, Fraser CC.

J Biol Chem. 2005 Oct 28;280(43):36510-7.

18.

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.

Lisi L, McGuire S, Sharp A, Chiosis G, Navarra P, Feinstein DL, Dello Russo C.

J Neuroimmunol. 2013 Feb 15;255(1-2):1-7. doi: 10.1016/j.jneuroim.2012.10.008.

20.

Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.

Mohan RR, Mohan RR, Kim WJ, Wilson SE.

Invest Ophthalmol Vis Sci. 2000 May;41(6):1327-36.

PMID:
10798647
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