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Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium.

Wilkinson SE, Furic L, Buchanan G, Larsson O, Pedersen J, Frydenberg M, Risbridger GP, Taylor RA.

Prostate. 2013 Dec;73(16):1810-23. doi: 10.1002/pros.22720. Epub 2013 Sep 16.


A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer.

Clark AK, Taubenberger AV, Taylor RA, Niranjan B, Chea ZY, Zotenko E, Sieh S, Pedersen JS, Norden S, Frydenberg M, Grummet JP, Pook DW; Australian Prostate Cancer BioResource., Stirzaker C, Clark SJ, Lawrence MG, Ellem SJ, Hutmacher DW, Risbridger GP.

Biomaterials. 2013 Jul;34(20):4777-85. doi: 10.1016/j.biomaterials.2013.03.005. Epub 2013 Apr 2.


The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts.

Shaw A, Gipp J, Bushman W.

Oncogene. 2009 Dec 17;28(50):4480-90. doi: 10.1038/onc.2009.294. Epub 2009 Sep 28.


Cancer stem cells and microenvironment in prostate cancer progression.

Liao CP, Adisetiyo H, Liang M, Roy-Burman P.

Horm Cancer. 2010 Dec;1(6):297-305. doi: 10.1007/s12672-010-0051-5.


LKB1 suppresses proliferation and invasion of prostate cancer through hedgehog signaling pathway.

Xu P, Cai F, Liu X, Guo L.

Int J Clin Exp Pathol. 2014 Dec 1;7(12):8480-8. eCollection 2014.


Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples.

Gravina GL, Mancini A, Ranieri G, Di Pasquale B, Marampon F, Di Clemente L, Ricevuto E, Festuccia C.

Int J Oncol. 2013 Jun;42(6):2116-22. doi: 10.3892/ijo.2013.1892. Epub 2013 Apr 10.


Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells.

Shigemura K, Huang WC, Li X, Zhau HE, Zhu G, Gotoh A, Fujisawa M, Xie J, Marshall FF, Chung LW.

Prostate. 2011 Dec;71(16):1711-22. doi: 10.1002/pros.21388. Epub 2011 Apr 25.


Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts.

Zhao H, Peehl DM.

Prostate. 2009 Jun 15;69(9):991-1000. doi: 10.1002/pros.20946.


Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer.

Hwang RF, Moore TT, Hattersley MM, Scarpitti M, Yang B, Devereaux E, Ramachandran V, Arumugam T, Ji B, Logsdon CD, Brown JL, Godin R.

Mol Cancer Res. 2012 Sep;10(9):1147-57. Epub 2012 Aug 2.


Paracrine sonic hedgehog signaling derived from tumor epithelial cells: a key regulator in the pancreatic tumor microenvironment.

Li X, Ma Q, Duan W, Liu H, Xu H, Wu E.

Crit Rev Eukaryot Gene Expr. 2012;22(2):97-108. Review.


Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium.

Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW.

Cancer Res. 2007 May 1;67(9):4244-53.


Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.

Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4254-9. doi: 10.1073/pnas.0813203106. Epub 2009 Feb 25.


Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells.

Plaisant M, Fontaine C, Cousin W, Rochet N, Dani C, Peraldi P.

Stem Cells. 2009 Mar;27(3):703-13. doi: 10.1634/stemcells.2008-0888.


Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer.

Joesting MS, Perrin S, Elenbaas B, Fawell SE, Rubin JS, Franco OE, Hayward SW, Cunha GR, Marker PC.

Cancer Res. 2005 Nov 15;65(22):10423-30.


Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b.

Karlou M, Lu JF, Wu G, Maity S, Tzelepi V, Navone NM, Hoang A, Logothetis CJ, Efstathiou E.

Prostate. 2012 Nov;72(15):1638-47. doi: 10.1002/pros.22517. Epub 2012 Mar 27.


Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression.

Azoulay S, Terry S, Chimingqi M, Sirab N, Faucon H, Gil Diez de Medina S, Moutereau S, Maillé P, Soyeux P, Abbou C, Salomon L, Vacherot F, de La Taille A, Loric S, Allory Y.

J Pathol. 2008 Dec;216(4):460-70. doi: 10.1002/path.2427.


Hedgehog signaling in prostate growth and benign prostate hyperplasia.

Vezina CM, Bushman AW.

Curr Urol Rep. 2007 Jul;8(4):275-80. Review.


Tumor-stromal interactions with direct cell contacts enhance motility of non-small cell lung cancer cells through the hedgehog signaling pathway.

Choe C, Shin YS, Kim SH, Jeon MJ, Choi SJ, Lee J, Kim J.

Anticancer Res. 2013 Sep;33(9):3715-23.


Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts.

Kaminski A, Hahne JC, Haddouti el-M, Florin A, Wellmann A, Wernert N.

Int J Mol Med. 2006 Nov;18(5):941-50.


Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR.

Clin Cancer Res. 2002 Sep;8(9):2912-23.

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