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Phosphatidic acid, phospholipase D and tumorigenesis.

Gomez-Cambronero J.

Adv Biol Regul. 2014 Jan;54:197-206. doi: 10.1016/j.jbior.2013.08.006. Epub 2013 Sep 19.


The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

Gomez-Cambronero J.

Cell Signal. 2011 Dec;23(12):1885-95. doi: 10.1016/j.cellsig.2011.06.017. Epub 2011 Jun 29. Review.


Overexpression of phospholipase D suppresses taxotere-induced cell death in stomach cancer cells.

Cho JH, Hong SK, Kim EY, Park SY, Park CH, Kim JM, Kwon OJ, Kwon SJ, Lee KS, Han JS.

Biochim Biophys Acta. 2008 May;1783(5):912-23. doi: 10.1016/j.bbamcr.2007.11.019. Epub 2007 Dec 15.


Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

Gomez-Cambronero J.

J Biol Chem. 2014 Aug 15;289(33):22557-66. doi: 10.1074/jbc.R114.574152. Epub 2014 Jul 2. Review.


Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells.

Kang DW, Park MH, Lee YJ, Kim HS, Lindsley CW, Alex Brown H, Min do S.

Int J Cancer. 2011 Feb 15;128(4):805-16. doi: 10.1002/ijc.25402.


Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.

Zhang F, Wang Z, Lu M, Yonekubo Y, Liang X, Zhang Y, Wu P, Zhou Y, Grinstein S, Hancock JF, Du G.

Mol Cell Biol. 2014 Jan;34(1):84-95. doi: 10.1128/MCB.00987-13. Epub 2013 Oct 28.


Reciprocal regulation of AMP-activated protein kinase and phospholipase D.

Mukhopadhyay S, Saqcena M, Chatterjee A, Garcia A, Frias MA, Foster DA.

J Biol Chem. 2015 Mar 13;290(11):6986-93. doi: 10.1074/jbc.M114.622571. Epub 2015 Jan 29.


Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts.

Thorsen VA, Vorland M, Bjørndal B, Bruland O, Holmsen H, Lillehaug JR.

Biochim Biophys Acta. 2003 Jun 10;1632(1-3):62-71.


Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.

Henkels KM, Boivin GP, Dudley ES, Berberich SJ, Gomez-Cambronero J.

Oncogene. 2013 Dec 5;32(49):5551-62. doi: 10.1038/onc.2013.207. Epub 2013 Jun 10.


Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways.

Meacci E, Nuti F, Catarzi S, Vasta V, Donati C, Bourgoin S, Bruni P, Moss J, Vaughan M.

Biochemistry. 2003 Jan 21;42(2):284-92.


Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid.

Han S, Huh J, Kim W, Jeong S, Min do S, Jung Y.

Exp Mol Med. 2014 Dec 19;46:e126. doi: 10.1038/emm.2014.86.


Phospholipase D meets Wnt signaling: a new target for cancer therapy.

Kang DW, Choi KY, Min do S.

Cancer Res. 2011 Jan 15;71(2):293-7. doi: 10.1158/0008-5472.CAN-10-2463. Epub 2011 Jan 11. Review. Erratum in: Cancer Res. 2011 Mar 15;71(6):2406.


Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners.

Jang JH, Lee CS, Hwang D, Ryu SH.

Prog Lipid Res. 2012 Apr;51(2):71-81. doi: 10.1016/j.plipres.2011.12.003. Epub 2011 Dec 28. Review.


Phospholipase D in platelets and other cells.

Vorland M, Thorsen VA, Holmsen H.

Platelets. 2008 Dec;19(8):582-94. doi: 10.1080/09537100802454992. Review.


A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells.

Fite K, Elkhadragy L, Gomez-Cambronero J.

Mol Cell Biol. 2016 Jan 19;36(7):1078-89. doi: 10.1128/MCB.00711-15.


New concepts in phospholipase D signaling in inflammation and cancer.

Gomez-Cambronero J.

ScientificWorldJournal. 2010 Jul 7;10:1356-69. doi: 10.1100/tsw.2010.116. Review.


Phospholipase D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells.

Qin H, Frohman MA, Bollag WB.

Endocrinology. 2010 May;151(5):2162-70. doi: 10.1210/en.2009-1159. Epub 2010 Mar 10.


Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR.

Lehman N, Ledford B, Di Fulvio M, Frondorf K, McPhail LC, Gomez-Cambronero J.

FASEB J. 2007 Apr;21(4):1075-87. Epub 2007 Jan 22.


Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).

Foster DA, Salloum D, Menon D, Frias MA.

J Biol Chem. 2014 Aug 15;289(33):22583-8. doi: 10.1074/jbc.R114.566091. Epub 2014 Jul 2. Review.

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