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Items: 1 to 20 of 107

1.

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins.

Christodoulou MS, Sacchetti A, Ronchetti V, Caufin S, Silvani A, Lesma G, Fontana G, Minicone F, Riva B, Ventura M, Lahtela-Kakkonen M, Jarho E, Zuco V, Zunino F, Martinet N, Dapiaggi F, Pieraccini S, Sironi M, Dalla Via L, Gia OM, Passarella D.

Bioorg Med Chem. 2013 Nov 15;21(22):6920-8. doi: 10.1016/j.bmc.2013.09.030. Epub 2013 Sep 19.

PMID:
24103429
2.
3.

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors.

Taliani S, Pugliesi I, Barresi E, Salerno S, Marchand C, Agama K, Simorini F, La Motta C, Marini AM, Di Leva FS, Marinelli L, Cosconati S, Novellino E, Pommier Y, Di Santo R, Da Settimo F.

J Med Chem. 2013 Sep 26;56(18):7458-62. doi: 10.1021/jm400932c. Epub 2013 Sep 16.

4.

Novel N-substituted sophoridinol derivatives as anticancer agents.

Bi CW, Zhang CX, Li YH, Tang S, Deng HB, Zhao WL, Wang Z, Shao RG, Song DQ.

Eur J Med Chem. 2014 Jun 23;81:95-105. doi: 10.1016/j.ejmech.2014.04.069. Epub 2014 May 2.

PMID:
24826818
5.

New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.

Kim SI, Lee SH, Lee ES, Lee CS, Jahng Y.

Arch Pharm Res. 2012 May;35(5):785-9. doi: 10.1007/s12272-012-0504-1. Epub 2012 May 29.

PMID:
22644846
6.

Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.

Cananzi S, Merlini L, Artali R, Beretta GL, Zaffaroni N, Dallavalle S.

Bioorg Med Chem. 2011 Aug 15;19(16):4971-84. doi: 10.1016/j.bmc.2011.06.056. Epub 2011 Jul 2.

PMID:
21783369
7.

Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.

Zhuo ST, Li CY, Hu MH, Chen SB, Yao PF, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.

Org Biomol Chem. 2013 Jun 28;11(24):3989-4005. doi: 10.1039/c3ob40325d.

PMID:
23657605
8.

Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors.

Ge R, Zhao Q, Xie Z, Lu L, Guo Q, Li Z, Zhao L.

Eur J Med Chem. 2016 Oct 21;122:465-474. doi: 10.1016/j.ejmech.2016.06.054. Epub 2016 Jul 1.

PMID:
27416553
9.

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling.

Le TN, Yang SH, Khadka DB, Van HT, Cho SH, Kwon Y, Lee ES, Lee KT, Cho WJ.

Bioorg Med Chem. 2011 Jul 15;19(14):4399-404. doi: 10.1016/j.bmc.2011.05.012. Epub 2011 May 20.

PMID:
21684168
10.

A new scaffold of topoisomerase I inhibitors: Design, synthesis and biological evaluation.

Mazza A, Beccalli EM, Contini A, Garcia-Argaez AN, Dalla Via L, Gelmi ML.

Eur J Med Chem. 2016 Nov 29;124:326-339. doi: 10.1016/j.ejmech.2016.08.045. Epub 2016 Aug 23.

PMID:
27597409
11.

Benzoquinazoline derivatives as new agents affecting DNA processing.

Marzaro G, Dalla Via L, Toninello A, Guiotto A, Chilin A.

Bioorg Med Chem. 2011 Feb 1;19(3):1197-204. doi: 10.1016/j.bmc.2010.12.037. Epub 2010 Dec 19.

PMID:
21216603
12.

Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.

Zhang C, Li S, Ji L, Liu S, Li Z, Li S, Meng X.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4693-6. doi: 10.1016/j.bmcl.2015.06.042. Epub 2015 Jun 26.

PMID:
26384290
13.

Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells.

Pan X, Hartley JM, Hartley JA, White KN, Wang Z, Bligh SW.

Phytomedicine. 2012 May 15;19(7):618-24. doi: 10.1016/j.phymed.2012.02.003. Epub 2012 Mar 6.

PMID:
22402246
14.

Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity.

Chan AL, Chang WS, Chen LM, Lee CM, Chen CE, Lin CM, Hwang JL.

Molecules. 2009 Mar 27;14(4):1342-52. doi: 10.3390/molecules14041342.

15.

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.

Lee CC, Chang DM, Huang KF, Chen CL, Chen TC, Lo Y, Guh JH, Huang HS.

Bioorg Med Chem. 2013 Nov 15;21(22):7125-33. doi: 10.1016/j.bmc.2013.09.006. Epub 2013 Sep 13.

PMID:
24094433
16.

Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors.

Peng CK, Zeng T, Xu XJ, Chang YQ, Hou W, Lu K, Lin H, Sun PH, Lin J, Chen WM.

Eur J Med Chem. 2017 Feb 15;127:187-199. doi: 10.1016/j.ejmech.2016.12.035. Epub 2016 Dec 20.

PMID:
28063351
17.

Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.

Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO.

Org Biomol Chem. 2013 Feb 28;11(8):1334-44. doi: 10.1039/c2ob27186a.

PMID:
23314103
18.

2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

Thapa P, Karki R, Yoo HY, Park PH, Lee E, Jeon KH, Na Y, Cho WJ, Kwon Y, Lee ES.

Bioorg Chem. 2012 Feb;40(1):67-78. doi: 10.1016/j.bioorg.2011.09.001. Epub 2011 Sep 8.

PMID:
22000119
19.

Synthesis of benzo-annulated tryptanthrins and their biological properties.

Liang JL, Park SE, Kwon Y, Jahng Y.

Bioorg Med Chem. 2012 Aug 15;20(16):4962-7. doi: 10.1016/j.bmc.2012.06.034. Epub 2012 Jul 2.

PMID:
22819942
20.

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.

Baechler SA, Fehr M, Habermeyer M, Hofmann A, Merz KH, Fiebig HH, Marko D, Eisenbrand G.

Bioorg Med Chem. 2013 Feb 1;21(3):814-23. doi: 10.1016/j.bmc.2012.11.011. Epub 2012 Nov 26.

PMID:
23266176

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