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Items: 1 to 20 of 121

1.

IQGAP1 plays an important role in the cell proliferation of multiple myeloma via the MAP kinase (ERK) pathway.

Ma Y, Jin Z, Huang J, Zhou S, Ye H, Jiang S, Yu K.

Oncol Rep. 2013 Dec;30(6):3032-8. doi: 10.3892/or.2013.2785. Epub 2013 Oct 3.

PMID:
24101133
2.

Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation.

Ma Y, Jin Z, Huang J, Zhou S, Ye H, Jiang S, Yu K.

Leuk Lymphoma. 2014 Nov;55(11):2597-604. doi: 10.3109/10428194.2013.879128. Epub 2014 Mar 7.

PMID:
24397597
3.
4.

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro.

Dong PX, Jia N, Xu ZJ, Liu YT, Li DJ, Feng YJ.

J Exp Clin Cancer Res. 2008 Nov 27;27:77. doi: 10.1186/1756-9966-27-77.

5.

IQGAP1 is a scaffold for mitogen-activated protein kinase signaling.

Roy M, Li Z, Sacks DB.

Mol Cell Biol. 2005 Sep;25(18):7940-52.

6.

The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway.

Cheung KL, Lee JH, Shu L, Kim JH, Sacks DB, Kong AN.

J Biol Chem. 2013 Aug 2;288(31):22378-86. doi: 10.1074/jbc.M112.444182. Epub 2013 Jun 20.

7.

A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells.

Iqbal MS, Tsuyama N, Obata M, Ishikawa H.

Biochem Biophys Res Commun. 2010 Feb 12;392(3):415-20. doi: 10.1016/j.bbrc.2010.01.038. Epub 2010 Jan 15.

PMID:
20079716
8.

IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.

Meng D, Wu W, Li Z, Qin G.

Int J Mol Med. 2015 Aug;36(2):588-94. doi: 10.3892/ijmm.2015.2232. Epub 2015 Jun 3.

PMID:
26046126
9.

miR-506 regulates breast cancer cell metastasis by targeting IQGAP1.

Sun G, Liu Y, Wang K, Xu Z.

Int J Oncol. 2015 Nov;47(5):1963-70. doi: 10.3892/ijo.2015.3161. Epub 2015 Sep 14.

PMID:
26398880
10.

IQGAP1 Scaffold-MAP Kinase Interactions Enhance Multiple Myeloma Clonogenic Growth and Self-Renewal.

Gocke CB, McMillan R, Wang Q, Begum A, Penchev VR, Ali SA, Borrello I, Huff CA, Matsui W.

Mol Cancer Ther. 2016 Nov;15(11):2733-2739. Epub 2016 Aug 29.

PMID:
27573425
11.

Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway.

Zhang TT, Jiang YY, Shang L, Shi ZZ, Liang JW, Wang Z, Zhang Y, Hao JJ, Jia XM, Xu X, Cai Y, Zhan QM, Wang MR.

Mol Carcinog. 2015 Oct;54(10):1205-13. doi: 10.1002/mc.22194. Epub 2014 Jul 7.

PMID:
25044025
12.

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G.

Cardiovasc Res. 2011 Aug 1;91(3):456-64. doi: 10.1093/cvr/cvr103. Epub 2011 Apr 14.

13.

[Effect of PI3Kδ inhibitor CAL-101 on myeloma cell lines and preliminary study of synergistic effects with other new drugs].

Zhang Q, Xia B, Qu F, Yuan T, Guo S, Zhao W, Li Q, Yang H, Wang Y, Zhang Y.

Zhonghua Xue Ye Xue Za Zhi. 2014 Oct;35(10):926-30. doi: 10.3760/cma.j.issn.0253-2727.2014.10.012. Chinese.

PMID:
25339332
14.

Increased fatty acid synthase as a potential therapeutic target in multiple myeloma.

Wang WQ, Zhao XY, Wang HY, Liang Y.

J Zhejiang Univ Sci B. 2008 Jun;9(6):441-7. doi: 10.1631/jzus.B0740640.

15.

Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.

Menu E, Kooijman R, Van Valckenborgh E, Asosingh K, Bakkus M, Van Camp B, Vanderkerken K.

Br J Cancer. 2004 Mar 8;90(5):1076-83.

16.

Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro.

Zhang H, Chen J, Zeng Z, Que W, Zhou L.

Int J Mol Med. 2013 May;31(5):1127-34. doi: 10.3892/ijmm.2013.1299. Epub 2013 Mar 12.

PMID:
23503641
17.

Knockdown of DEPTOR inhibits cell proliferation and increases chemosensitivity to melphalan in human multiple myeloma RPMI-8226 cells via inhibiting PI3K/AKT activity.

Zhang HR, Chen JM, Zeng ZY, Que WZ.

J Int Med Res. 2013 Jun;41(3):584-95. doi: 10.1177/0300060513480920. Epub 2013 Apr 15.

PMID:
23613505
20.

IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.

Chen F, Zhu HH, Zhou LF, Wu SS, Wang J, Chen Z.

Exp Mol Med. 2010 Jul 31;42(7):477-83.

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