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Items: 1 to 20 of 83

1.

Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7.

Tabet S, Douglas SF, Daze KD, Garnett GA, Allen KJ, Abrioux EM, Quon TT, Wulff JE, Hof F.

Bioorg Med Chem. 2013 Nov 15;21(22):7004-10. doi: 10.1016/j.bmc.2013.09.024. Epub 2013 Sep 19.

PMID:
24100156
2.

Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).

Simhadri C, Daze KD, Douglas SF, Quon TT, Dev A, Gignac MC, Peng F, Heller M, Boulanger MJ, Wulff JE, Hof F.

J Med Chem. 2014 Apr 10;57(7):2874-83. doi: 10.1021/jm401487x. Epub 2014 Mar 26.

PMID:
24625057
3.

Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain.

Ren C, Morohashi K, Plotnikov AN, Jakoncic J, Smith SG, Li J, Zeng L, Rodriguez Y, Stojanoff V, Walsh M, Zhou MM.

Chem Biol. 2015 Feb 19;22(2):161-8. doi: 10.1016/j.chembiol.2014.11.021. Epub 2015 Feb 5.

4.

Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes.

Kimura Y, Saito N, Hanada K, Liu J, Okabe T, Kawashima SA, Yamatsugu K, Kanai M.

Chembiochem. 2015 Dec;16(18):2599-604. doi: 10.1002/cbic.201500448. Epub 2015 Nov 18.

PMID:
26503405
5.

Global histone H3 lysine 27 triple methylation levels are reduced in vessels with advanced atherosclerotic plaques.

Wierda RJ, Rietveld IM, van Eggermond MC, Belien JA, van Zwet EW, Lindeman JH, van den Elsen PJ.

Life Sci. 2015 May 15;129:3-9. doi: 10.1016/j.lfs.2014.10.010. Epub 2014 Oct 31.

PMID:
25445221
6.

Inhibition of histone binding by supramolecular hosts.

Allen HF, Daze KD, Shimbo T, Lai A, Musselman CA, Sims JK, Wade PA, Hof F, Kutateladze TG.

Biochem J. 2014 May 1;459(3):505-12. doi: 10.1042/BJ20140145.

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The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.

Kycia I, Kudithipudi S, Tamas R, Kungulovski G, Dhayalan A, Jeltsch A.

J Mol Biol. 2014 Apr 17;426(8):1651-60. doi: 10.1016/j.jmb.2013.08.009. Epub 2013 Aug 15.

PMID:
23954330
10.

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.

Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD.

Mol Cell Biol. 2006 Apr;26(7):2560-9.

11.

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).

Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, MacKenzie F, Pan P, Li SS, Wang H, Min J.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19266-71. doi: 10.1073/pnas.1008937107. Epub 2010 Oct 25.

12.

Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes.

Kim DH, Tang Z, Shimada M, Fierz B, Houck-Loomis B, Bar-Dagen M, Lee S, Lee SK, Muir TW, Roeder RG, Lee JW.

Mol Cell Biol. 2013 Dec;33(24):4936-46. doi: 10.1128/MCB.00601-13. Epub 2013 Oct 14.

13.

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.

Tie F, Banerjee R, Stratton CA, Prasad-Sinha J, Stepanik V, Zlobin A, Diaz MO, Scacheri PC, Harte PJ.

Development. 2009 Sep;136(18):3131-41. doi: 10.1242/dev.037127.

14.

Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.

Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou MM.

Mol Cell. 2010 Jun 11;38(5):662-74. doi: 10.1016/j.molcel.2010.03.021.

15.

Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.

Jung HR, Pasini D, Helin K, Jensen ON.

Mol Cell Proteomics. 2010 May;9(5):838-50. doi: 10.1074/mcp.M900489-MCP200. Epub 2010 Feb 11.

16.

Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.

Li Q, Wang X, Lu Z, Zhang B, Guan Z, Liu Z, Zhong Q, Gu L, Zhou J, Zhu B, Ji J, Deng D.

PLoS One. 2010 Oct 29;5(10):e13732. doi: 10.1371/journal.pone.0013732.

17.

Dynamics of H3K27me3 methylation and demethylation in plant development.

Gan ES, Xu Y, Ito T.

Plant Signal Behav. 2015;10(9):e1027851. doi: 10.1080/15592324.2015.1027851. Review.

18.

H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma.

Chen S, Chen J, Zhan Q, Zhu Y, Chen H, Deng X, Hou Z, Shen B, Chen Y, Peng C.

Oncotarget. 2014 Nov 15;5(21):10421-33.

19.

Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks.

Chen Z, Grzybowski AT, Ruthenburg AJ.

Chembiochem. 2014 Sep 22;15(14):2071-5. doi: 10.1002/cbic.201402313. Epub 2014 Aug 22.

20.

Histone methylation by PRC2 is inhibited by active chromatin marks.

Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH.

Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025.

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