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Items: 1 to 20 of 177

1.

Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.

Woo CC, Hsu A, Kumar AP, Sethi G, Tan KH.

PLoS One. 2013 Oct 2;8(10):e75356. doi: 10.1371/journal.pone.0075356. eCollection 2013.

2.

Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway.

Yu SM, Kim SJ.

Exp Biol Med (Maywood). 2013 Jul;238(7):811-20. doi: 10.1177/1535370213492685. Epub 2013 Jun 20.

PMID:
23788172
3.

Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro.

Zhu WQ, Wang J, Guo XF, Liu Z, Dong WG.

World J Gastroenterol. 2016 Apr 28;22(16):4149-59. doi: 10.3748/wjg.v22.i16.4149.

4.

Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.

Rajput S, Kumar BN, Sarkar S, Das S, Azab B, Santhekadur PK, Das SK, Emdad L, Sarkar D, Fisher PB, Mandal M.

PLoS One. 2013 Apr 17;8(4):e61342. doi: 10.1371/journal.pone.0061342. Print 2013.

5.

Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.

Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M.

Life Sci. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15.

PMID:
24044882
6.

Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling.

El-Najjar N, Chatila M, Moukadem H, Vuorela H, Ocker M, Gandesiri M, Schneider-Stock R, Gali-Muhtasib H.

Apoptosis. 2010 Feb;15(2):183-95. doi: 10.1007/s10495-009-0421-z.

PMID:
19882352
7.

Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent autophagy.

Chu SC, Hsieh YS, Yu CC, Lai YY, Chen PN.

PLoS One. 2014 Jul 7;9(7):e101579. doi: 10.1371/journal.pone.0101579. eCollection 2014.

8.

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.

Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH.

Biochem Pharmacol. 2011 Sep 1;82(5):464-75. doi: 10.1016/j.bcp.2011.05.030. Epub 2011 Jun 14.

PMID:
21679698
9.

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.

Arafa el-SA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA.

Mutat Res. 2011 Jan 10;706(1-2):28-35. doi: 10.1016/j.mrfmmm.2010.10.007. Epub 2010 Oct 30.

10.

SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway.

Wang LH, Li HH, Li M, Wang S, Jiang XR, Li Y, Ping GF, Cao Q, Liu X, Fang WH, Chen GL, Yang JY, Wu CF.

Cell Prolif. 2015 Dec;48(6):718-28. doi: 10.1111/cpr.12226. Epub 2015 Oct 26.

PMID:
26500049
11.

Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo.

Xu D, Ma Y, Zhao B, Li S, Zhang Y, Pan S, Wu Y, Wang J, Wang D, Pan H, Liu L, Jiang H.

Oncol Rep. 2014 May;31(5):2063-70. doi: 10.3892/or.2014.3059. Epub 2014 Mar 5.

PMID:
24603952
12.

AD-1, a novel ginsenoside derivative, shows anti-lung cancer activity via activation of p38 MAPK pathway and generation of reactive oxygen species.

Zhang LH, Jia YL, Lin XX, Zhang HQ, Dong XW, Zhao JM, Shen J, Shen HJ, Li FF, Yan XF, Li W, Zhao YQ, Xie QM.

Biochim Biophys Acta. 2013 Aug;1830(8):4148-59. doi: 10.1016/j.bbagen.2013.04.008. Epub 2013 Apr 11.

PMID:
23583729
13.

Nonthermal plasma induces head and neck cancer cell death: the potential involvement of mitogen-activated protein kinase-dependent mitochondrial reactive oxygen species.

Kang SU, Cho JH, Chang JW, Shin YS, Kim KI, Park JK, Yang SS, Lee JS, Moon E, Lee K, Kim CH.

Cell Death Dis. 2014 Feb 13;5:e1056. doi: 10.1038/cddis.2014.33.

15.

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species.

Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC.

Exp Biol Med (Maywood). 2010 Jun;235(6):751-60. doi: 10.1258/ebm.2010.009369.

PMID:
20511679
16.

Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.

Lei X, Lv X, Liu M, Yang Z, Ji M, Guo X, Dong W.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):864-8. doi: 10.1016/j.bbrc.2011.12.063. Epub 2011 Dec 20.

PMID:
22206670
17.

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.

Jafri SH, Glass J, Shi R, Zhang S, Prince M, Kleiner-Hancock H.

J Exp Clin Cancer Res. 2010 Jul 1;29:87. doi: 10.1186/1756-9966-29-87.

18.

Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models.

Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El-Hajj Z, Diestel A, Evert M, El-Najjar N, Peters B, Jurjus A, Roessner A, Schneider-Stock R.

J Cell Mol Med. 2008 Jan-Feb;12(1):330-42. doi: 10.1111/j.1582-4934.2007.00095.x.

19.

Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo.

Attoub S, Sperandio O, Raza H, Arafat K, Al-Salam S, Al Sultan MA, Al Safi M, Takahashi T, Adem A.

Fundam Clin Pharmacol. 2013 Oct;27(5):557-69. doi: 10.1111/j.1472-8206.2012.01056.x. Epub 2012 Jul 13.

PMID:
22788741
20.

CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction.

Yang CR, Liao WS, Wu YH, Murugan K, Chen C, Chao JI.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):611-22. doi: 10.1016/j.taap.2013.10.007. Epub 2013 Oct 12.

PMID:
24128853

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