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Items: 1 to 20 of 114

1.

Mutation screen of the SIM1 gene in pediatric patients with early-onset obesity.

Zegers D, Beckers S, Hendrickx R, Van Camp JK, de Craemer V, Verrijken A, Van Hoorenbeeck K, Verhulst SL, Rooman RP, Desager KN, Massa G, Van Gaal LF, Van Hul W.

Int J Obes (Lond). 2014 Jul;38(7):1000-4. doi: 10.1038/ijo.2013.188. Epub 2013 Oct 7.

PMID:
24097297
2.

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features.

Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdy V, Pattou F, Van Hul W, Van Gaal L, Peet DJ, Weill J, Miller JL, Horber F, Goldstone AP, Driscoll DJ, Bruning JB, Meyre D, Whitelaw ML, Froguel P.

J Clin Invest. 2013 Jul;123(7):3037-41. doi: 10.1172/JCI68035. Epub 2013 Jun 17.

3.

Rare variants in single-minded 1 (SIM1) are associated with severe obesity.

Ramachandrappa S, Raimondo A, Cali AM, Keogh JM, Henning E, Saeed S, Thompson A, Garg S, Bochukova EG, Brage S, Trowse V, Wheeler E, Sullivan AE, Dattani M, Clayton PE, Datta V, Bruning JB, Wareham NJ, O'Rahilly S, Peet DJ, Barroso I, Whitelaw ML, Farooqi IS.

J Clin Invest. 2013 Jul;123(7):3042-50. doi: 10.1172/JCI68016. Epub 2013 Jun 17. Erratum in: J Clin Invest. 2013 Aug 1;123(8):3635. Datta, Vippan [corrected to Datta, Vipan].

4.

Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay.

Montagne L, Raimondo A, Delobel B, Duban-Bedu B, Noblet FS, Dechaume A, Bersten DC, Meyre D, Whitelaw ML, Froguel P, Bonnefond A.

Obesity (Silver Spring). 2014 Dec;22(12):2621-4. doi: 10.1002/oby.20886. Epub 2014 Sep 19.

5.

Studies of the SIM1 gene in relation to human obesity and obesity-related traits.

Hung CC, Luan J, Sims M, Keogh JM, Hall C, Wareham NJ, O'Rahilly S, Farooqi IS.

Int J Obes (Lond). 2007 Mar;31(3):429-34. Epub 2006 Aug 22.

PMID:
16924270
6.

Copy number variation (CNV) analysis and mutation analysis of the 6q14.1-6q16.3 genes SIM1 and MRAP2 in Prader Willi like patients.

Geets E, Zegers D, Beckers S, Verrijken A, Massa G, Van Hoorenbeeck K, Verhulst S, Van Gaal L, Van Hul W.

Mol Genet Metab. 2016 Mar;117(3):383-8. doi: 10.1016/j.ymgme.2016.01.003. Epub 2016 Jan 9.

PMID:
26795956
7.

Functional characterization of SIM1-associated enhancers.

Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N.

Hum Mol Genet. 2014 Apr 1;23(7):1700-8. doi: 10.1093/hmg/ddt559. Epub 2013 Nov 7.

8.

Replication and extension of association between common genetic variants in SIM1 and human adiposity.

Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC.

Obesity (Silver Spring). 2011 Dec;19(12):2394-2403. doi: 10.1038/oby.2011.79. Epub 2011 Apr 21.

9.

Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescents.

Stanikova D, Buzga M, Krumpolec P, Skopkova M, Surova M, Ukropcova B, Ticha L, Petrasova M, Gabcova D, Huckova M, Piskorova L, Bozensky J, Mokan M, Ukropec J, Zavacka I, Klimes I, Stanik J, Gasperikova D.

PLoS One. 2017 May 4;12(5):e0177222. doi: 10.1371/journal.pone.0177222. eCollection 2017.

10.

Screening for genetic variants in BDNF that contribute to childhood obesity.

Zegers D, Hendrickx R, Verrijken A, Van Hoorenbeeck K, Van Camp JK, de Craemer V, Rooman RP, Desager KN, Massa G, Van Gaal LF, Van Hul W, Beckers S.

Pediatr Obes. 2014 Feb;9(1):36-42. doi: 10.1111/j.2047-6310.2012.00131.x. Epub 2013 Jan 16.

PMID:
23325614
11.

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.

Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR.

Mol Endocrinol. 2008 Jul;22(7):1723-34. doi: 10.1210/me.2008-0067. Epub 2008 May 1.

12.

Prevalence of rare MC3R variants in obese cases and lean controls.

Zegers D, Beckers S, Hendrickx R, Van Camp JK, Van Hoorenbeeck K, Desager KN, Massa G, Van Gaal LF, Van Hul W.

Endocrine. 2013 Oct;44(2):386-90. doi: 10.1007/s12020-012-9862-1. Epub 2012 Dec 24.

PMID:
23264184
13.

Analysis of the SIM1 contribution to polygenic obesity in the French population.

Ghoussaini M, Stutzmann F, Couturier C, Vatin V, Durand E, Lecoeur C, Degraeve F, Heude B, Tauber M, Hercberg S, Levy-Marchal C, Tounian P, Weill J, Traurig M, Bogardus C, Baier LJ, Michaud JL, Froguel P, Meyre D.

Obesity (Silver Spring). 2010 Aug;18(8):1670-5. doi: 10.1038/oby.2009.468. Epub 2010 Jan 14.

14.

Paraventricular nucleus Sim1 neuron ablation mediated obesity is resistant to high fat diet.

Xi D, Roizen J, Lai M, Gandhi N, Kublaoui B.

PLoS One. 2013 Nov 19;8(11):e81087. doi: 10.1371/journal.pone.0081087. eCollection 2013.

15.

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

Sullivan AE, Raimondo A, Schwab TA, Bruning JB, Froguel P, Farooqi IS, Peet DJ, Whitelaw ML.

Biochem J. 2014 Aug 1;461(3):403-12. doi: 10.1042/BJ20131618.

PMID:
24814368
16.

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.

Traurig M, Mack J, Hanson RL, Ghoussaini M, Meyre D, Knowler WC, Kobes S, Froguel P, Bogardus C, Baier LJ.

Diabetes. 2009 Jul;58(7):1682-9. doi: 10.2337/db09-0028. Epub 2009 Apr 28.

17.

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.

Volckmar AL, Bolze F, Jarick I, Knoll N, Scherag A, Reinehr T, Illig T, Grallert H, Wichmann HE, Wiegand S, Biebermann H, Krude H, Fischer-Posovszky P, Rief W, Wabitsch M, Klingenspor M, Hebebrand J, Hinney A.

BMC Med Genomics. 2012 Dec 27;5:65. doi: 10.1186/1755-8794-5-65.

18.

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene.

Holder JL Jr, Butte NF, Zinn AR.

Hum Mol Genet. 2000 Jan 1;9(1):101-8.

PMID:
10587584
19.

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.

Kublaoui BM, Holder JL Jr, Tolson KP, Gemelli T, Zinn AR.

Endocrinology. 2006 Oct;147(10):4542-9. Epub 2006 May 18.

PMID:
16709610
20.

Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.

Xi D, Gandhi N, Lai M, Kublaoui BM.

PLoS One. 2012;7(4):e36453. doi: 10.1371/journal.pone.0036453. Epub 2012 Apr 27.

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