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Items: 1 to 20 of 248

1.

Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.

Li SY, Wang XB, Xie SS, Jiang N, Wang KD, Yao HQ, Sun HB, Kong LY.

Eur J Med Chem. 2013 Nov;69:632-46. doi: 10.1016/j.ejmech.2013.09.024. Epub 2013 Sep 21.

PMID:
24095756
2.

Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.

Xie SS, Wang XB, Li JY, Yang L, Kong LY.

Eur J Med Chem. 2013 Jun;64:540-53. doi: 10.1016/j.ejmech.2013.03.051. Epub 2013 Apr 6.

PMID:
23685572
3.

Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY.

Bioorg Med Chem. 2014 Nov 1;22(21):6089-104. doi: 10.1016/j.bmc.2014.08.035. Epub 2014 Sep 15.

PMID:
25282654
4.

O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.

Mao F, Huang L, Luo Z, Liu A, Lu C, Xie Z, Li X.

Bioorg Med Chem. 2012 Oct 1;20(19):5884-92. doi: 10.1016/j.bmc.2012.07.045. Epub 2012 Aug 15.

PMID:
22944335
5.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

Fernández-Bachiller MI, Pérez C, Monjas L, Rademann J, Rodríguez-Franco MI.

J Med Chem. 2012 Feb 9;55(3):1303-17. doi: 10.1021/jm201460y. Epub 2012 Jan 27.

PMID:
22243648
6.

Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.

Sang Z, Qiang X, Li Y, Yuan W, Liu Q, Shi Y, Ang W, Luo Y, Tan Z, Deng Y.

Eur J Med Chem. 2015 Apr 13;94:348-66. doi: 10.1016/j.ejmech.2015.02.063. Epub 2015 Mar 4.

PMID:
25778991
7.

Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer's Disease.

Fu Y, Mu Y, Lei H, Wang P, Li X, Leng Q, Han L, Qu X, Wang Z, Huang X.

Molecules. 2016 Oct 11;21(10). pii: E1338.

8.

Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Li SY, Jiang N, Xie SS, Wang KD, Wang XB, Kong LY.

Org Biomol Chem. 2014 Feb 7;12(5):801-14. doi: 10.1039/c3ob42010h. Epub 2013 Dec 6.

PMID:
24310227
9.

Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.

Xie SS, Lan JS, Wang XB, Jiang N, Dong G, Li ZR, Wang KD, Guo PP, Kong LY.

Eur J Med Chem. 2015 Mar 26;93:42-50. doi: 10.1016/j.ejmech.2015.01.058. Epub 2015 Jan 28.

PMID:
25656088
10.

Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.

Li Y, Qiang X, Li Y, Yang X, Luo L, Xiao G, Cao Z, Tan Z, Deng Y.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):2035-9. doi: 10.1016/j.bmcl.2016.02.079. Epub 2016 Feb 27.

PMID:
26947607
11.

Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Wang XQ, Xia CL, Chen SB, Tan JH, Ou TM, Huang SL, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2015 Jan 7;89:349-61. doi: 10.1016/j.ejmech.2014.10.018. Epub 2014 Oct 18.

PMID:
25462251
12.

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

Fernández-Bachiller MI, Pérez C, González-Muñoz GC, Conde S, López MG, Villarroya M, García AG, Rodríguez-Franco MI.

J Med Chem. 2010 Jul 8;53(13):4927-37. doi: 10.1021/jm100329q.

PMID:
20545360
13.

Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.

Luo W, Li YP, He Y, Huang SL, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2011 Jun;46(6):2609-16. doi: 10.1016/j.ejmech.2011.03.058. Epub 2011 Apr 3.

PMID:
21497959
14.

Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.

Huang L, Su T, Shan W, Luo Z, Sun Y, He F, Li X.

Bioorg Med Chem. 2012 May 1;20(9):3038-48. doi: 10.1016/j.bmc.2012.02.059. Epub 2012 Mar 10.

PMID:
22472046
15.

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

He Y, Yao PF, Chen SB, Huang ZH, Huang SL, Tan JH, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2013 May;63:299-312. doi: 10.1016/j.ejmech.2013.02.014. Epub 2013 Feb 26.

PMID:
23501115
16.

Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

Thiratmatrakul S, Yenjai C, Waiwut P, Vajragupta O, Reubroycharoen P, Tohda M, Boonyarat C.

Eur J Med Chem. 2014 Mar 21;75:21-30. doi: 10.1016/j.ejmech.2014.01.020. Epub 2014 Jan 22.

PMID:
24508831
17.

Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.

Manral A, Saini V, Meena P, Tiwari M.

Bioorg Med Chem. 2015 Oct 1;23(19):6389-403. doi: 10.1016/j.bmc.2015.08.024. Epub 2015 Aug 22.

PMID:
26337018
18.

Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload.

Wang Y, Wang F, Yu JP, Jiang FC, Guan XL, Wang CM, Li L, Cao H, Li MX, Chen JG.

Bioorg Med Chem. 2012 Nov 1;20(21):6513-22. doi: 10.1016/j.bmc.2012.08.040. Epub 2012 Aug 30.

PMID:
23000296
19.

Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.

Li RS, Wang XB, Hu XJ, Kong LY.

Bioorg Med Chem Lett. 2013 May 1;23(9):2636-41. doi: 10.1016/j.bmcl.2013.02.095. Epub 2013 Mar 1.

PMID:
23511019
20.

Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.

Fernández-Bachiller MI, Pérez C, Campillo NE, Páez JA, González-Muñoz GC, Usán P, García-Palomero E, López MG, Villarroya M, García AG, Martínez A, Rodríguez-Franco MI.

ChemMedChem. 2009 May;4(5):828-41. doi: 10.1002/cmdc.200800414.

PMID:
19308922

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