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Ikaros' suspended flight in the thymus.

Taylor N, Zimmermann VS.

Blood. 2013 Oct 3;122(14):2291-2. doi: 10.1182/blood-2013-08-519835. No abstract available.


Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.

Tinsley KW, Hong C, Luckey MA, Park JY, Kim GY, Yoon HW, Keller HR, Sacks AJ, Feigenbaum L, Park JH.

Blood. 2013 Oct 3;122(14):2358-68. doi: 10.1182/blood-2012-12-472076. Epub 2013 Aug 1.


Ikaros represses the transcriptional response to Notch signaling in T-cell development.

Kleinmann E, Geimer Le Lay AS, Sellars M, Kastner P, Chan S.

Mol Cell Biol. 2008 Dec;28(24):7465-75. doi: 10.1128/MCB.00715-08. Epub 2008 Oct 13.


Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells".

Verhagen J, Wraith DC.

J Immunol. 2010 Dec 15;185(12):7129; author reply 7130. doi: 10.4049/jimmunol.1090105. No abstract available.


Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.

Naito T, Gómez-Del Arco P, Williams CJ, Georgopoulos K.

Immunity. 2007 Nov;27(5):723-34. Epub 2007 Nov 1.


Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM.

J Immunol. 2010 Apr 1;184(7):3433-41. doi: 10.4049/jimmunol.0904028. Epub 2010 Feb 24.


Stage-specific control of early B cell development by the transcription factor Ikaros.

Schwickert TA, Tagoh H, Gültekin S, Dakic A, Axelsson E, Minnich M, Ebert A, Werner B, Roth M, Cimmino L, Dickins RA, Zuber J, Jaritz M, Busslinger M.

Nat Immunol. 2014 Mar;15(3):283-93. doi: 10.1038/ni.2828. Epub 2014 Feb 9.


Ikaros induces quiescence and T-cell differentiation in a leukemia cell line.

Kathrein KL, Lorenz R, Innes AM, Griffiths E, Winandy S.

Mol Cell Biol. 2005 Mar;25(5):1645-54.


The linkage between T-cell and dendritic cell development in the mouse thymus.

Shortman K, Vremec D, Corcoran LM, Georgopoulos K, Lucas K, Wu L.

Immunol Rev. 1998 Oct;165:39-46. Review.


Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator.

Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST.

Genes Dev. 2001 Jul 15;15(14):1817-32.


Ikaros has a crucial role in regulation of B cell receptor signaling.

Nera KP, Alinikula J, Terho P, Narvi E, Törnquist K, Kurosaki T, Buerstedde JM, Lassila O.

Eur J Immunol. 2006 Mar;36(3):516-25.


Bringing the thymus to the bench.

Anderson G, Jenkinson EJ.

J Immunol. 2008 Dec 1;181(11):7435-6. Review. No abstract available.


Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation.

Gurel Z, Ronni T, Ho S, Kuchar J, Payne KJ, Turk CW, Dovat S.

J Biol Chem. 2008 Mar 28;283(13):8291-300. doi: 10.1074/jbc.M707906200. Epub 2008 Jan 27.


GATA-3 locks the door to the B-cell option.

Rothenberg EV.

Blood. 2013 Mar 7;121(10):1673-4. doi: 10.1182/blood-2013-01-477737.


Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.

Joshi I, Yoshida T, Jena N, Qi X, Zhang J, Van Etten RA, Georgopoulos K.

Nat Immunol. 2014 Mar;15(3):294-304. doi: 10.1038/ni.2821. Epub 2014 Feb 9.


Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.

Georgopoulos K, Moore DD, Derfler B.

Science. 1992 Oct 30;258(5083):808-12.


The thymus and T-cell commitment: the right niche for Notch?

Jenkinson EJ, Jenkinson WE, Rossi SW, Anderson G.

Nat Rev Immunol. 2006 Jul;6(7):551-5. Review.


Cutting edge: Ikaros is a regulator of Th2 cell differentiation.

Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA.

J Immunol. 2009 Jan 15;182(2):741-5.


Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus.

Klug DB, Carter C, Gimenez-Conti IB, Richie ER.

J Immunol. 2002 Sep 15;169(6):2842-5.

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