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Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration.

Xing B, Wang L, Guo D, Huang J, Espenel C, Kreitzer G, Zhang JJ, Guo L, Huang XY.

J Biol Chem. 2013 Nov 15;288(46):32827-36. doi: 10.1074/jbc.M113.489427. Epub 2013 Oct 3.


Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.

Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY.

J Biol Chem. 2011 Sep 2;286(35):31055-61. doi: 10.1074/jbc.M111.253427. Epub 2011 Jul 19.


Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF beta-receptor.

Ruusala A, Sundberg C, Arvidsson AK, Rupp-Thuresson E, Heldin CH, Claesson-Welsh L.

J Cell Sci. 1998 Jan;111 ( Pt 1):111-20.


EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.

Rosenfeldt HM, Hobson JP, Maceyka M, Olivera A, Nava VE, Milstien S, Spiegel S.

FASEB J. 2001 Dec;15(14):2649-59.


Ric-8A, a guanine nucleotide exchange factor for heterotrimeric G proteins, is critical for cranial neural crest cell migration.

Fuentealba J, Toro-Tapia G, Arriagada C, Riquelme L, Beyer A, Henriquez JP, Caprile T, Mayor R, Marcellini S, Hinrichs MV, Olate J, Torrejón M.

Dev Biol. 2013 Jun 15;378(2):74-82. doi: 10.1016/j.ydbio.2013.04.005. Epub 2013 Apr 12.


Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta.

Li W, Yu JC, Michieli P, Beeler JF, Ellmore N, Heidaran MA, Pierce JH.

Mol Cell Biol. 1994 Oct;14(10):6727-35.


Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis.

Hooshmand-Rad R, Claesson-Welsh L, Wennström S, Yokote K, Siegbahn A, Heldin CH.

Exp Cell Res. 1997 Aug 1;234(2):434-41.


EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

Akimoto K, Takahashi R, Moriya S, Nishioka N, Takayanagi J, Kimura K, Fukui Y, Osada Si, Mizuno K, Hirai Si, Kazlauskas A, Ohno S.

EMBO J. 1996 Feb 15;15(4):788-98.


Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits.

Chan P, Thomas CJ, Sprang SR, Tall GG.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3794-9. doi: 10.1073/pnas.1220943110. Epub 2013 Feb 19.


Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Hansen K, Johnell M, Siegbahn A, Rorsman C, Engström U, Wernstedt C, Heldin CH, Rönnstrand L.

EMBO J. 1996 Oct 1;15(19):5299-313.


Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.

Chan P, Gabay M, Wright FA, Tall GG.

J Biol Chem. 2011 Jun 3;286(22):19932-42. doi: 10.1074/jbc.M110.163675. Epub 2011 Apr 5.


Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement.

Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB.

J Biol Chem. 2003 Aug 1;278(31):28793-8. Epub 2003 May 16.


Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.

Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M.

Exp Cell Res. 2000 Jun 15;257(2):245-54.


Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

Kant R, Zeng B, Thomas CJ, Bothner B, Sprang SR.

Elife. 2016 Dec 23;5. pii: e19238. doi: 10.7554/eLife.19238.


Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association.

Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG.

Sci Signal. 2011 Nov 22;4(200):ra79. doi: 10.1126/scisignal.2002223.

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