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Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells.

Vyas AR, Singh SV.

Eur J Nutr. 2014 Apr;53(3):843-52. doi: 10.1007/s00394-013-0588-5. Epub 2013 Oct 4.


Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration.

Hahm ER, Chandra-Kuntal K, Desai D, Amin S, Singh SV.

PLoS One. 2012;7(9):e44957. doi: 10.1371/journal.pone.0044957. Epub 2012 Sep 7.


In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells.

Sakao K, Hahm ER, Singh SV.

Nutr Cancer. 2013;65 Suppl 1:61-7. doi: 10.1080/01635581.2013.785002.


Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.

Beaver LM, Buchanan A, Sokolowski EI, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E.

Mol Nutr Food Res. 2014 Oct;58(10):2001-13. doi: 10.1002/mnfr.201400269. Epub 2014 Aug 5.


D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.

Choi S, Lew KL, Xiao H, Herman-Antosiewicz A, Xiao D, Brown CK, Singh SV.

Carcinogenesis. 2007 Jan;28(1):151-62. Epub 2006 Aug 18.


Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.

Hahm ER, Singh SV.

Cancer Prev Res (Phila). 2010 Apr;3(4):484-94. doi: 10.1158/1940-6207.CAPR-09-0250. Epub 2010 Mar 16.


CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.

Sakao K, Vyas AR, Chinni SR, Amjad AI, Parikh R, Singh SV.

Cancer Prev Res (Phila). 2015 May;8(5):365-74. doi: 10.1158/1940-6207.CAPR-14-0386. Epub 2015 Feb 23.


Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.

Herman-Antosiewicz A, Xiao H, Lew KL, Singh SV.

Mol Cancer Ther. 2007 May;6(5):1673-81.


Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy.

Vyas AR, Hahm ER, Arlotti JA, Watkins S, Stolz DB, Desai D, Amin S, Singh SV.

Cancer Res. 2013 Oct 1;73(19):5985-95. doi: 10.1158/0008-5472.CAN-13-0755. Epub 2013 Aug 6.


Deregulated expression of urokinase and its inhibitor type 1 in prostate cancer cells: role of epigenetic mechanisms.

Hagelgans A, Menschikowski M, Fuessel S, Nacke B, Arneth BM, Wirth MP, Siegert G.

Exp Mol Pathol. 2013 Jun;94(3):458-65. doi: 10.1016/j.yexmp.2013.03.006. Epub 2013 Mar 27.


Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells.

Tian H, Zhou Y, Yang G, Geng Y, Wu S, Hu Y, Lin K, Wu W.

Oncol Rep. 2016 Sep;36(3):1361-8. doi: 10.3892/or.2016.4942. Epub 2016 Jul 15.


Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E.

Mol Nutr Food Res. 2011 Jul;55(7):999-1009. doi: 10.1002/mnfr.201000547. Epub 2011 Mar 4.


Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells.

Cho SD, Li G, Hu H, Jiang C, Kang KS, Lee YS, Kim SH, Lu J.

Nutr Cancer. 2005;52(2):213-24.


D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.

Kim SH, Singh SV.

Mol Cancer Ther. 2009 Jul;8(7):1946-54. doi: 10.1158/1535-7163.MCT-09-0104. Epub 2009 Jul 7.


Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.

Singh AV, Xiao D, Lew KL, Dhir R, Singh SV.

Carcinogenesis. 2004 Jan;25(1):83-90. Epub 2003 Sep 26.


Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A.

J Biol Chem. 2005 May 20;280(20):19911-24. Epub 2005 Mar 11.


Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.

Wang L, Liu D, Ahmed T, Chung FL, Conaway C, Chiao JW.

Int J Oncol. 2004 Jan;24(1):187-92.


Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells.

Sehrawat A, Singh SV.

Cancer Prev Res (Phila). 2011 Jul;4(7):1107-17. doi: 10.1158/1940-6207.CAPR-10-0306. Epub 2011 Apr 4.


D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.

Sakao K, Singh SV.

J Cell Biochem. 2012 Feb;113(2):599-610. doi: 10.1002/jcb.23386.

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