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A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo.

Cha JR, St Louis KJ, Tradewell ML, Gentil BJ, Minotti S, Jaffer ZM, Chen R, Rubenstein AE, Durham HD.

Cell Stress Chaperones. 2014 May;19(3):421-35. doi: 10.1007/s12192-013-0467-2.


Expression of the protein chaperone, clusterin, in spinal cord cells constitutively and following cellular stress, and upregulation by treatment with Hsp90 inhibitor.

Zinkie S, Gentil BJ, Minotti S, Durham HD.

Cell Stress Chaperones. 2013 Nov;18(6):745-58. doi: 10.1007/s12192-013-0427-x.


Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis.

Liu J, Shinobu LA, Ward CM, Young D, Cleveland DW.

J Neurochem. 2005 May;93(4):875-82.


Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.

Taylor DM, Tradewell ML, Minotti S, Durham HD.

Cell Stress Chaperones. 2007 Summer;12(2):151-62.


The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, Galbiati M, Fontana E, Marino M, Carra S, Bendotti C, De Biasi S, Poletti A.

Hum Mol Genet. 2010 Sep 1;19(17):3440-56. doi: 10.1093/hmg/ddq257.


Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis.

Batulan Z, Taylor DM, Aarons RJ, Minotti S, Doroudchi MM, Nalbantoglu J, Durham HD.

Neurobiol Dis. 2006 Nov;24(2):213-25.


The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme.

Zhu H, Woolfenden S, Bronson RT, Jaffer ZM, Barluenga S, Winssinger N, Rubenstein AE, Chen R, Charest A.

Mol Cancer Ther. 2010 Sep;9(9):2618-26. doi: 10.1158/1535-7163.MCT-10-0248.


Differential effects of mutant SOD1 on protein structure of skeletal muscle and spinal cord of familial amyotrophic lateral sclerosis: role of chaperone network.

Wei R, Bhattacharya A, Hamilton RT, Jernigan AL, Chaudhuri AR.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):218-23. doi: 10.1016/j.bbrc.2013.07.060.


Over-expression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Krishnan J, Vannuvel K, Andries M, Waelkens E, Robberecht W, Van Den Bosch L.

J Neurochem. 2008 Sep;106(5):2170-83. doi: 10.1111/j.1471-4159.2008.05545.x.


Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.

Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD.

Neurobiol Dis. 2001 Dec;8(6):933-41.


Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.

Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR.

J Neurochem. 2015 May;133(3):452-64. doi: 10.1111/jnc.13022.


Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Novoselov SS, Mustill WJ, Gray AL, Dick JR, Kanuga N, Kalmar B, Greensmith L, Cheetham ME.

PLoS One. 2013 Aug 30;8(8):e73944. doi: 10.1371/journal.pone.0073944.


High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

Batulan Z, Shinder GA, Minotti S, He BP, Doroudchi MM, Nalbantoglu J, Strong MJ, Durham HD.

J Neurosci. 2003 Jul 2;23(13):5789-98.


The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43.

Tran LT, Gentil BJ, Sullivan KE, Durham HD.

J Neurochem. 2014 Aug;130(3):455-66. doi: 10.1111/jnc.12738.


Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria.

Bilsland LG, Nirmalananthan N, Yip J, Greensmith L, Duchen MR.

J Neurochem. 2008 Dec;107(5):1271-83. doi: 10.1111/j.1471-4159.2008.05699.x.


Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.

Tanaka K, Eskin A, Chareyre F, Jessen WJ, Manent J, Niwa-Kawakita M, Chen R, White CH, Vitte J, Jaffer ZM, Nelson SF, Rubenstein AE, Giovannini M.

Clin Cancer Res. 2013 Jul 15;19(14):3856-70. doi: 10.1158/1078-0432.CCR-12-3167.


Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.

Song W, Song Y, Kincaid B, Bossy B, Bossy-Wetzel E.

Neurobiol Dis. 2013 Mar;51:72-81. doi: 10.1016/j.nbd.2012.07.004.


Effects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model.

Zhao Z, Sui Y, Gao W, Cai B, Fan D.

J Int Med Res. 2015 Feb;43(1):67-79. doi: 10.1177/0300060514554725.


Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells.

Patel YJ, Payne Smith MD, de Belleroche J, Latchman DS.

Brain Res Mol Brain Res. 2005 Apr 4;134(2):256-74.


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