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In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection.

Snauwaert S, Verstichel G, Bonte S, Goetgeluk G, Vanhee S, Van Caeneghem Y, De Mulder K, Heirman C, Stauss H, Heemskerk MH, Taghon T, Leclercq G, Plum J, Langerak AW, Thielemans K, Kerre T, Vandekerckhove B.

Leukemia. 2014 Apr;28(4):830-41. doi: 10.1038/leu.2013.285. Epub 2013 Oct 4.


T cell receptor (TCR) gene transfer with lentiviral vectors allows efficient redirection of tumor specificity in naive and memory T cells without prior stimulation of endogenous TCR.

Circosta P, Granziero L, Follenzi A, Vigna E, Stella S, Vallario A, Elia AR, Gammaitoni L, Vitaggio K, Orso F, Geuna M, Sangiolo D, Todorovic M, Giachino C, Cignetti A.

Hum Gene Ther. 2009 Dec;20(12):1576-88. doi: 10.1089/hum.2009.117.


Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.

Van Coppernolle S, Verstichel G, Timmermans F, Velghe I, Vermijlen D, De Smedt M, Leclercq G, Plum J, Taghon T, Vandekerckhove B, Kerre T.

J Immunol. 2009 Oct 15;183(8):4859-70. doi: 10.4049/jimmunol.0900714.


TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation.

Blom B, Verschuren MC, Heemskerk MH, Bakker AQ, van Gastel-Mol EJ, Wolvers-Tettero IL, van Dongen JJ, Spits H.

Blood. 1999 May 1;93(9):3033-43.


Consequences of intrathymic TCR engagement by partial agonist on selection events and peripheral T cell activation program.

Auphan N, Simon AK, Asnagli H, Phillips RJ, Rincon M, Ghosh S, Flavell RA, Schmitt-Verhulst AM.

J Immunol. 1998 May 15;160(10):4810-21.


T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway.

Shores EW, Sharrow SO, Uppenkamp I, Singer A.

Eur J Immunol. 1990 Jan;20(1):69-77.


Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression.

Vatakis DN, Arumugam B, Kim SG, Bristol G, Yang O, Zack JA.

Mol Ther. 2013 May;21(5):1055-63. doi: 10.1038/mt.2013.28. Epub 2013 Mar 12.


A new mechanism shapes the naïve CD8+ T cell repertoire: the selection for full diversity.

Gonçalves P, Ferrarini M, Molina-Paris C, Lythe G, Vasseur F, Lim A, Rocha B, Azogui O.

Mol Immunol. 2017 May;85:66-80. doi: 10.1016/j.molimm.2017.01.026. Epub 2017 Mar 8.


An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8+ T Cells.

Kondo K, Fujiki F, Nakajima H, Yatsukawa E, Morimoto S, Tatsumi N, Nishida S, Nakata J, Oka Y, Tsuboi A, Hosen N, Oji Y, Sugiyama H.

J Immunother. 2016 Apr;39(3):127-39. doi: 10.1097/CJI.0000000000000114.


Human effector T cells derived from central memory cells rather than CD8(+)T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy.

Wu F, Zhang W, Shao H, Bo H, Shen H, Li J, Liu Y, Wang T, Ma W, Huang S.

Cancer Lett. 2013 Oct 10;339(2):195-207. doi: 10.1016/j.canlet.2013.06.009. Epub 2013 Jun 18.


Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice.

Hu Z, Xia J, Fan W, Wargo J, Yang YG.

Oncotarget. 2016 Feb 9;7(6):6448-59. doi: 10.18632/oncotarget.7044.


High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens.

Morgan RA, Dudley ME, Yu YY, Zheng Z, Robbins PF, Theoret MR, Wunderlich JR, Hughes MS, Restifo NP, Rosenberg SA.

J Immunol. 2003 Sep 15;171(6):3287-95.


Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ.

Int Immunol. 2007 Dec;19(12):1421-30. Epub 2007 Nov 1.


Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.

Awong G, Herer E, La Motte-Mohs RN, Zúñiga-Pflücker JC.

BMC Immunol. 2011 Mar 23;12:22. doi: 10.1186/1471-2172-12-22.


Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.

Dossett ML, Teague RM, Schmitt TM, Tan X, Cooper LJ, Pinzon C, Greenberg PD.

Mol Ther. 2009 Apr;17(4):742-9. doi: 10.1038/mt.2008.300. Epub 2009 Feb 10.


Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor.

Roszkowski JJ, Lyons GE, Kast WM, Yee C, Van Besien K, Nishimura MI.

Cancer Res. 2005 Feb 15;65(4):1570-6.


Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

Dervovic DD, Ciofani M, Kianizad K, Zúñiga-Pflücker JC.

J Immunol. 2012 Oct 1;189(7):3411-20. Epub 2012 Aug 27.

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