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Identification of novel small molecule inhibitors of centrosome clustering in cancer cells.

Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S.

Oncotarget. 2013 Oct;4(10):1763-76.


A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.

Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S.

Oncogene. 2011 Feb 3;30(5):521-34. doi: 10.1038/onc.2010.431. Epub 2010 Sep 13.


Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen.

Rebacz B, Larsen TO, Clausen MH, Rønnest MH, Löffler H, Ho AD, Krämer A.

Cancer Res. 2007 Jul 1;67(13):6342-50.


Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM.

Cancer Res. 2017 Sep 15;77(18):4785-4796. doi: 10.1158/0008-5472.CAN-16-3233. Epub 2017 Jul 18.


A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.

Castiel A, Visochek L, Mittelman L, Dantzer F, Izraeli S, Cohen-Armon M.

BMC Cancer. 2011 Sep 26;11:412. doi: 10.1186/1471-2407-11-412.


Proteins required for centrosome clustering in cancer cells.

Leber B, Maier B, Fuchs F, Chi J, Riffel P, Anderhub S, Wagner L, Ho AD, Salisbury JL, Boutros M, Krämer A.

Sci Transl Med. 2010 May 26;2(33):33ra38. doi: 10.1126/scitranslmed.3000915.


HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients.

Pannu V, Rida PC, Ogden A, Turaga RC, Donthamsetty S, Bowen NJ, Rudd K, Gupta MV, Reid MD, Cantuaria G, Walczak CE, Aneja R.

Oncotarget. 2015 Mar 20;6(8):6076-91.


Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.

Kleylein-Sohn J, Pöllinger B, Ohmer M, Hofmann F, Nigg EA, Hemmings BA, Wartmann M.

J Cell Sci. 2012 Nov 15;125(Pt 22):5391-402. doi: 10.1242/jcs.107474. Epub 2012 Sep 3.


Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death.

Ogden A, Cheng A, Rida PC, Pannu V, Osan R, Clewley R, Aneja R.

Cell Death Dis. 2014 May 1;5:e1204. doi: 10.1038/cddis.2014.164.


Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication.

Liang YX, Zhang W, Li DD, Liu HT, Gao P, Sun YN, Shao RG.

World J Gastroenterol. 2004 Sep 15;10(18):2632-6.


Using Cell Culture Models of Centrosome Amplification to Study Centrosome Clustering in Cancer.

Kwon M.

Methods Mol Biol. 2016;1413:367-92. doi: 10.1007/978-1-4939-3542-0_23.


Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.

Castiel A, Visochek L, Mittelman L, Zilberstein Y, Dantzer F, Izraeli S, Cohen-Armon M.

J Vis Exp. 2013 Aug 21;(78):e50568. doi: 10.3791/50568.


Dis-organizing centrosomal clusters: specific cancer therapy for a generic spread?

Bhakta-Guha D, Saeed ME, Greten HJ, Efferth T.

Curr Med Chem. 2015;22(6):685-94. Review.


Centrosomal clustering contributes to chromosomal instability and cancer.

Milunović-Jevtić A, Mooney P, Sulerud T, Bisht J, Gatlin JC.

Curr Opin Biotechnol. 2016 Aug;40:113-118. doi: 10.1016/j.copbio.2016.03.011. Epub 2016 Apr 2. Review.


Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy.

Ogden A, Rida PC, Aneja R.

Cell Death Differ. 2012 Aug;19(8):1255-67. doi: 10.1038/cdd.2012.61. Epub 2012 Jun 1. Review.


Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.

Montañez-Wiscovich ME, Shelton MD, Seachrist DD, Lozada KL, Johnson E, Miedler JD, Abdul-Karim FW, Visvader JE, Keri RA.

J Pathol. 2010 Nov;222(3):271-81. doi: 10.1002/path.2762.


GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo.

Raab MS, Breitkreutz I, Anderhub S, Rønnest MH, Leber B, Larsen TO, Weiz L, Konotop G, Hayden PJ, Podar K, Fruehauf J, Nissen F, Mier W, Haberkorn U, Ho AD, Goldschmidt H, Anderson KC, Clausen MH, Krämer A.

Cancer Res. 2012 Oct 15;72(20):5374-85. doi: 10.1158/0008-5472.CAN-12-2026. Epub 2012 Aug 31.


Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell death.

Abal M, Souto AA, Amat-Guerri F, Acuña AU, Andreu JM, Barasoain I.

Cell Motil Cytoskeleton. 2001 May;49(1):1-15.


From fertilization to cancer: the role of centrosomes in the union and separation of genomic material.

Schatten H, Hueser CN, Chakrabarti A.

Microsc Res Tech. 2000 Jun 1;49(5):420-7.


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