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mTOR regulates phagosome and entotic vacuole fission.

Krajcovic M, Krishna S, Akkari L, Joyce JA, Overholtzer M.

Mol Biol Cell. 2013 Dec;24(23):3736-45. doi: 10.1091/mbc.E13-07-0408. Epub 2013 Oct 2.


PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

Krishna S, Palm W, Lee Y, Yang W, Bandyopadhyay U, Xu H, Florey O, Thompson CB, Overholtzer M.

Dev Cell. 2016 Sep 12;38(5):536-47. doi: 10.1016/j.devcel.2016.08.001.


Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes.

Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M.

Nat Cell Biol. 2011 Oct 16;13(11):1335-43. doi: 10.1038/ncb2363.


V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation.

Florey O, Gammoh N, Kim SE, Jiang X, Overholtzer M.

Autophagy. 2015;11(1):88-99. doi: 10.4161/15548627.2014.984277.


Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.

Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I, Jovic M, Backer JM, Balla T, Hilbi H, Haas A.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4636-41. doi: 10.1073/pnas.1423456112. Epub 2015 Mar 30.


Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages.

Liebl D, Griffiths G.

J Cell Sci. 2009 Aug 15;122(Pt 16):2935-45. doi: 10.1242/jcs.048355. Epub 2009 Jul 28.


Autophagy proteins in macroendocytic engulfment.

Florey O, Overholtzer M.

Trends Cell Biol. 2012 Jul;22(7):374-80. doi: 10.1016/j.tcb.2012.04.005. Epub 2012 May 19. Review.


PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.

Kim GH, Dayam RM, Prashar A, Terebiznik M, Botelho RJ.

Traffic. 2014 Oct;15(10):1143-63. doi: 10.1111/tra.12199. Epub 2014 Aug 16.


Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.

Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Cano M, Hackett S, Xu G, Lutty GA, Dong L, Sergeev Y, Handa JT, Campochiaro P, Wawrousek E, Zigler JS Jr, Sinha D.

Autophagy. 2014 Mar;10(3):480-96. doi: 10.4161/auto.27292. Epub 2014 Jan 23.


The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation.

Dayam RM, Saric A, Shilliday RE, Botelho RJ.

Traffic. 2015 Sep;16(9):1010-26. doi: 10.1111/tra.12303. Epub 2015 Jun 18.


Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages.

Duclos S, Diez R, Garin J, Papadopoulou B, Descoteaux A, Stenmark H, Desjardins M.

J Cell Sci. 2000 Oct;113 Pt 19:3531-41.


IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium.

Nguyen T, Robinson N, Allison SE, Coombes BK, Sad S, Krishnan L.

Placenta. 2013 Sep;34(9):765-74. doi: 10.1016/j.placenta.2013.06.003. Epub 2013 Jul 5.


Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.


How nascent phagosomes mature to become phagolysosomes.

Fairn GD, Grinstein S.

Trends Immunol. 2012 Aug;33(8):397-405. doi: 10.1016/ Epub 2012 May 3. Review.


A vesicle surface tyrosine kinase regulates phagosome maturation.

Fang J, Brzostowski JA, Ou S, Isik N, Nair V, Jin T.

J Cell Biol. 2007 Jul 30;178(3):411-23.


Autophagy proteins regulate cell engulfment mechanisms that participate in cancer.

Kim SE, Overholtzer M.

Semin Cancer Biol. 2013 Oct;23(5):329-36. doi: 10.1016/j.semcancer.2013.05.004. Epub 2013 May 30. Review.


Internalized Listeria monocytogenes modulates intracellular trafficking and delays maturation of the phagosome.

Alvarez-Dominguez C, Roberts R, Stahl PD.

J Cell Sci. 1997 Mar;110 ( Pt 6):731-43.


Rheb and Rags come together at the lysosome to activate mTORC1.

Groenewoud MJ, Zwartkruis FJ.

Biochem Soc Trans. 2013 Aug;41(4):951-5. doi: 10.1042/BST20130037. Review.


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