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JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

Granato M, Santarelli R, Lotti LV, Di Renzo L, Gonnella R, Garufi A, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

PLoS One. 2013 Sep 26;8(9):e75965. doi: 10.1371/journal.pone.0075965. eCollection 2013.


Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation.

Li C, Johnson DE.

Cancer Lett. 2012 Jan 1;314(1):102-7. doi: 10.1016/j.canlet.2011.09.020. Epub 2011 Sep 24.


Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells.

Selimovic D, Porzig BB, El-Khattouti A, Badura HE, Ahmad M, Ghanjati F, Santourlidis S, Haikel Y, Hassan M.

Cell Signal. 2013 Jan;25(1):308-18. doi: 10.1016/j.cellsig.2012.10.004. Epub 2012 Oct 15. Erratum in: Cell Signal. 2015 Mar;27(3):727. Cell Signal. 2015 May;27(5):1019-1020.


Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress.

Dasmahapatra G, Lembersky D, Rahmani M, Kramer L, Friedberg J, Fisher RI, Dent P, Grant S.

Cancer Biol Ther. 2009 May;8(9):808-19. Epub 2009 May 8.


Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.

Rao R, Nalluri S, Fiskus W, Savoie A, Buckley KM, Ha K, Balusu R, Joshi A, Coothankandaswamy V, Tao J, Sotomayor E, Atadja P, Bhalla KN.

Clin Cancer Res. 2010 Oct 1;16(19):4742-54. doi: 10.1158/1078-0432.CCR-10-0529. Epub 2010 Jul 20.


Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.

Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV.

Autophagy. 2010 Jan;6(1):19-35.


Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.

Kao C, Chao A, Tsai CL, Chuang WC, Huang WP, Chen GC, Lin CY, Wang TH, Wang HS, Lai CH.

Cell Death Dis. 2014 Nov 6;5:e1510. doi: 10.1038/cddis.2014.468.


Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.

Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM.

Autophagy. 2013 Feb 1;9(2):208-19. doi: 10.4161/auto.22801. Epub 2012 Nov 26.


Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.

Brüning A, Rahmeh M, Friese K.

Mol Oncol. 2013 Dec;7(6):1012-8. doi: 10.1016/j.molonc.2013.07.010. Epub 2013 Jul 20.


Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells.

Moriya S, Che XF, Komatsu S, Abe A, Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K.

Int J Oncol. 2013 May;42(5):1541-50. doi: 10.3892/ijo.2013.1870. Epub 2013 Mar 28.


Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells.

Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A.

Int J Oncol. 2012 Apr;40(4):1029-39. doi: 10.3892/ijo.2011.1317. Epub 2011 Dec 23.


Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro.

Lou Z, Ren T, Peng X, Sun Y, Jiao G, Lu Q, Zhang S, Lu X, Guo W.

J Int Med Res. 2013 Oct;41(5):1505-19. doi: 10.1177/0300060513490618. Epub 2013 Aug 23.


Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells.

Jia L, Gopinathan G, Sukumar JT, Gribben JG.

PLoS One. 2012;7(2):e32584. doi: 10.1371/journal.pone.0032584. Epub 2012 Feb 29.


Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.

Cirone M, Di Renzo L, Lotti LV, Conte V, Trivedi P, Santarelli R, Gonnella R, Frati L, Faggioni A.

PLoS One. 2012;7(3):e31732. doi: 10.1371/journal.pone.0031732. Epub 2012 Mar 7.


Protein kinase CK2 inhibition down modulates the NF-κB and STAT3 survival pathways, enhances the cellular proteotoxic stress and synergistically boosts the cytotoxic effect of bortezomib on multiple myeloma and mantle cell lymphoma cells.

Manni S, Brancalion A, Mandato E, Tubi LQ, Colpo A, Pizzi M, Cappellesso R, Zaffino F, Di Maggio SA, Cabrelle A, Marino F, Zambello R, Trentin L, Adami F, Gurrieri C, Semenzato G, Piazza F.

PLoS One. 2013 Sep 27;8(9):e75280. doi: 10.1371/journal.pone.0075280. eCollection 2013.


Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.

Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CP, Fimia GM, Piacentini M, Lovat PE.

Clin Cancer Res. 2011 Apr 15;17(8):2216-26. doi: 10.1158/1078-0432.CCR-10-3003. Epub 2011 Jan 26.


JNK and AP-1 mediate apoptosis induced by bortezomib in HepG2 cells via FasL/caspase-8 and mitochondria-dependent pathways.

Lauricella M, Emanuele S, D'Anneo A, Calvaruso G, Vassallo B, Carlisi D, Portanova P, Vento R, Tesoriere G.

Apoptosis. 2006 Apr;11(4):607-25.


Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.

Min H, Xu M, Chen ZR, Zhou JD, Huang M, Zheng K, Zou XP.

Cancer Chemother Pharmacol. 2014 Jul;74(1):167-76. doi: 10.1007/s00280-014-2451-7. Epub 2014 May 20.


Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma.

Sarosiek KA, Cavallin LE, Bhatt S, Toomey NL, Natkunam Y, Blasini W, Gentles AJ, Ramos JC, Mesri EA, Lossos IS.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13069-74. doi: 10.1073/pnas.1002985107. Epub 2010 Jul 6.

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