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Items: 1 to 20 of 128

1.

Streptochlorin suppresses allergic dermatitis and mast cell activation via regulation of Lyn/Fyn and Syk signaling pathways in cellular and mouse models.

Lee SH, Shin HJ, Kim DY, Shim DW, Kim TJ, Ye SK, Won HS, Koppula S, Kang TB, Lee KH.

PLoS One. 2013 Sep 27;8(9):e74194. doi: 10.1371/journal.pone.0074194. eCollection 2013.

2.

Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity.

Kim JH, Kim AR, Kim HS, Kim HW, Park YH, You JS, Park YM, Her E, Kim HS, Kim YM, Choi WS.

BMC Complement Altern Med. 2015 Mar 25;15:80. doi: 10.1186/s12906-015-0607-6.

3.

The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.

Lee JH, Kim JW, Kim DK, Kim HS, Park HJ, Park DK, Kim AR, Kim B, Beaven MA, Park KL, Kim YM, Choi WS.

J Immunol. 2011 Aug 15;187(4):1807-15. doi: 10.4049/jimmunol.1100296. Epub 2011 Jul 11.

4.

Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation.

Sanderson MP, Wex E, Kono T, Uto K, Schnapp A.

Mol Immunol. 2010 Nov-Dec;48(1-3):171-8. doi: 10.1016/j.molimm.2010.08.012. Epub 2010 Sep 15.

PMID:
20828828
5.

Homoisoflavanone prevents mast cell activation and allergic responses by inhibition of Syk signaling pathway.

Lee YS, Hur S, Kim TY.

Allergy. 2014 Apr;69(4):453-62. doi: 10.1111/all.12356. Epub 2014 Jan 22.

6.

Inhibitory effects of mulberry fruit extract in combination with naringinase on the allergic response in IgE-activated RBL-2H3 cells.

Yoo JM, Kim NY, Seo JM, Kim SJ, Lee SY, Kim SK, Kim HD, Lee SW, Kim MR.

Int J Mol Med. 2014 Feb;33(2):469-77. doi: 10.3892/ijmm.2013.1590. Epub 2013 Dec 13.

PMID:
24336971
7.

An indoxyl compound 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, suppresses activation of Fyn kinase in mast cells and IgE-mediated allergic responses in mice.

Lee JH, Kim TH, Kim HS, Kim AR, Kim DK, Nam ST, Kim HW, Park YH, Her E, Park YM, Kim HS, Kim YM, Choi WS.

Toxicol Appl Pharmacol. 2015 Jun 15;285(3):179-86. doi: 10.1016/j.taap.2015.04.009. Epub 2015 Apr 19.

PMID:
25902337
8.

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk.

Lee JH, Kim JW, Ko NY, Mun SH, Her E, Kim BK, Han JW, Lee HY, Beaven MA, Kim YM, Choi WS.

J Allergy Clin Immunol. 2008 May;121(5):1225-31. doi: 10.1016/j.jaci.2007.12.1160. Epub 2008 Apr 18.

PMID:
18394691
9.

Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells.

Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Kim HS, Lee KR, Kim YK, Radinger M, Her E, Choi WS.

Clin Exp Allergy. 2008 May;38(5):794-804. doi: 10.1111/j.1365-2222.2008.02936.x. Epub 2008 Feb 2.

PMID:
18261158
10.

A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally.

Mazuc E, Villoutreix BO, Malbec O, Roumier T, Fleury S, Leonetti JP, Dombrowicz D, Daëron M, Martineau P, Dariavach P.

J Allergy Clin Immunol. 2008 Jul;122(1):188-94, 194.e1-3. doi: 10.1016/j.jaci.2008.04.026. Epub 2008 Jun 9.

PMID:
18539317
11.

PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.

Samayawardhena LA, Pallen CJ.

J Immunol. 2010 Nov 15;185(10):5993-6002. doi: 10.4049/jimmunol.1001261. Epub 2010 Oct 13.

12.

Morus bombycis extract suppresses mast cell activation and IgE-mediated allergic reaction in mice.

Kim JD, Kim DK, Kim HS, Kim AR, Kim B, Her E, Park KH, Kim HS, Kim YM, Choi WS.

J Ethnopharmacol. 2013 Mar 7;146(1):287-93. doi: 10.1016/j.jep.2012.12.046. Epub 2013 Jan 9.

PMID:
23313390
13.

Morin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo.

Kim JW, Lee JH, Hwang BY, Mun SH, Ko NY, Kim DK, Kim B, Kim HS, Kim YM, Choi WS.

Biochem Pharmacol. 2009 May 1;77(9):1506-12. doi: 10.1016/j.bcp.2009.01.019. Epub 2009 Feb 6.

PMID:
19426688
14.

Anti-inflammatory effect of Streptochlorin via TRIF-dependent signaling pathways in cellular and mouse models.

Shim DW, Shin HJ, Han JW, Shin WY, Sun X, Shim EJ, Kim TJ, Kang TB, Lee KH.

Int J Mol Sci. 2015 Mar 26;16(4):6902-10. doi: 10.3390/ijms16046902.

15.
16.

Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice.

Kitaura J, Kawakami Y, Maeda-Yamamoto M, Horejsi V, Kawakami T.

J Immunol. 2007 Jan 1;178(1):455-62.

17.

Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.

Lu Y, Yang JH, Li X, Hwangbo K, Hwang SL, Taketomi Y, Murakami M, Chang YC, Kim CH, Son JK, Chang HW.

Biochem Pharmacol. 2011 Dec 1;82(11):1700-8. doi: 10.1016/j.bcp.2011.08.022. Epub 2011 Sep 3.

PMID:
21907188
18.

Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses.

Akimoto M, Mishra K, Lim KT, Tani N, Hisanaga SI, Katagiri T, Elson A, Mizuno K, Yakura H.

Scand J Immunol. 2009 May;69(5):401-11. doi: 10.1111/j.1365-3083.2009.02235.x. Epub 2008 Feb 6.

19.

A novel imidazo[1,5-b]isoquinolinone derivative, U63A05, inhibits Syk activation in mast cells to suppress IgE-mediated anaphylaxis in mice.

Kim DK, Lee JH, Kim JW, Kim HS, Kim AR, Kim BK, Yi KY, Park HJ, Park DK, Choi WS.

J Pharmacol Sci. 2011;115(4):500-8.

20.

A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.

Shim DW, Shin HJ, Han JW, Ji YE, Jang CH, Koppula S, Kang TB, Lee KH.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):227-35. doi: 10.1016/j.taap.2015.02.006. Epub 2015 Feb 14.

PMID:
25689174
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