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The LKB1 tumor suppressor as a biomarker in mouse and human tissues.

Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH.

PLoS One. 2013 Sep 25;8(9):e73449. doi: 10.1371/journal.pone.0073449.


Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

J Biol. 2003;2(4):28.


The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35.


LKB1 modulates lung cancer differentiation and metastasis.

Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK.

Nature. 2007 Aug 16;448(7155):807-10.


Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.

Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D.

Breast Cancer Res. 2012 Feb 21;14(1):R35.


Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, Westra WH, Herman JG, Sidransky D.

Cancer Res. 2002 Jul 1;62(13):3659-62.


Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review).

Li N, Huang D, Lu N, Luo L.

Oncol Rep. 2015 Dec;34(6):2821-6. doi: 10.3892/or.2015.4288. Review.


Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.

Churchman M, Dowling B, Tomlinson IP.

DNA Seq. 1999;10(4-5):255-61.


Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN, Schorge JO, Broaddus RR, Wong KK, Bardeesy N, Castrillon DH.

Cancer Res. 2008 Feb 1;68(3):759-66. doi: 10.1158/0008-5472.CAN-07-5014.


Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.

Guldberg P, thor Straten P, Ahrenkiel V, Seremet T, Kirkin AF, Zeuthen J.

Oncogene. 1999 Mar 4;18(9):1777-80.


The tumor suppressor kinase LKB1: lessons from mouse models.

Ollila S, Mäkelä TP.

J Mol Cell Biol. 2011 Dec;3(6):330-40. doi: 10.1093/jmcb/mjr016. Review.


Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.

Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W, Tomlinson I.

J Invest Dermatol. 1999 Apr;112(4):509-11.


Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.

Boudeau J, Kieloch A, Alessi DR, Stella A, Guanti G, Resta N.

Hum Mutat. 2003 Feb;21(2):172.


Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene.

Carretero J, Medina PP, Pio R, Montuenga LM, Sanchez-Cespedes M.

Oncogene. 2004 May 13;23(22):4037-40.


Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.

Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.

Nature. 2002 Sep 12;419(6903):162-7.


LKB1; linking cell structure and tumor suppression.

Hezel AF, Bardeesy N.

Oncogene. 2008 Nov 24;27(55):6908-19. doi: 10.1038/onc.2008.342. Review.


STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

Koyama S, Akbay EA, Li YY, Aref AR, Skoulidis F, Herter-Sprie GS, Buczkowski KA, Liu Y, Awad MM, Denning WL, Diao L, Wang J, Parra-Cuentas ER, Wistuba II, Soucheray M, Thai T, Asahina H, Kitajima S, Altabef A, Cavanaugh JD, Rhee K, Gao P, Zhang H, Fecci PE, Shimamura T, Hellmann MD, Heymach JV, Hodi FS, Freeman GJ, Barbie DA, Dranoff G, Hammerman PS, Wong KK.

Cancer Res. 2016 Mar 1;76(5):999-1008. doi: 10.1158/0008-5472.CAN-15-1439.


Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H, Billaud M.

Hum Mol Genet. 2005 May 15;14(10):1283-92.


Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.

Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG.

Oncogene. 2000 Jan 6;19(1):164-8.

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