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NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.

He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DC.

J Clin Invest. 2013 Nov;123(11):4821-35.


Expression of CCAAT/Enhancer Binding Protein Beta in Muscle Satellite Cells Inhibits Myogenesis in Cancer Cachexia.

Marchildon F, Lamarche É, Lala-Tabbert N, St-Louis C, Wiper-Bergeron N.

PLoS One. 2015 Dec 28;10(12):e0145583. doi: 10.1371/journal.pone.0145583.


NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.

Guttridge DC, Mayo MW, Madrid LV, Wang CY, Baldwin AS Jr.

Science. 2000 Sep 29;289(5488):2363-6.


Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development.

Mitchell KJ, Pannérec A, Cadot B, Parlakian A, Besson V, Gomes ER, Marazzi G, Sassoon DA.

Nat Cell Biol. 2010 Mar;12(3):257-66. doi: 10.1038/ncb2025.


Sulf1A and HGF regulate satellite-cell growth.

Gill R, Hitchins L, Fletcher F, Dhoot GK.

J Cell Sci. 2010 Jun 1;123(Pt 11):1873-83. doi: 10.1242/jcs.061242.


Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia.

Op den Kamp CM, Langen RC, Snepvangers FJ, de Theije CC, Schellekens JM, Laugs F, Dingemans AM, Schols AM.

Am J Clin Nutr. 2013 Sep;98(3):738-48. doi: 10.3945/ajcn.113.058388.


Myostatin is a novel tumoral factor that induces cancer cachexia.

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.

Biochem J. 2012 Aug 15;446(1):23-36. doi: 10.1042/BJ20112024. Erratum in: Biochem J. 2015 Feb 15;466(1):201. Retraction in: Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M. Biochem J. 2016 Apr 15;473(8):1111.


Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells.

Wen Y, Bi P, Liu W, Asakura A, Keller C, Kuang S.

Mol Cell Biol. 2012 Jun;32(12):2300-11. doi: 10.1128/MCB.06753-11.


Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting.

Shum AM, Mahendradatta T, Taylor RJ, Painter AB, Moore MM, Tsoli M, Tan TC, Clarke SJ, Robertson GR, Polly P.

Aging (Albany NY). 2012 Feb;4(2):133-43.


C26 cancer-induced muscle wasting is IKKβ-dependent and NF-kappaB-independent.

Cornwell EW, Mirbod A, Wu CL, Kandarian SC, Jackman RW.

PLoS One. 2014 Jan 29;9(1):e87776. doi: 10.1371/journal.pone.0087776.


MicroRNA-431 accelerates muscle regeneration and ameliorates muscular dystrophy by targeting Pax7 in mice.

Wu R, Li H, Zhai L, Zou X, Meng J, Zhong R, Li C, Wang H, Zhang Y, Zhu D.

Nat Commun. 2015 Jul 7;6:7713. doi: 10.1038/ncomms8713.


Pax7 is critical for the normal function of satellite cells in adult skeletal muscle.

von Maltzahn J, Jones AE, Parks RJ, Rudnicki MA.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16474-9. doi: 10.1073/pnas.1307680110.


Origin and hierarchy of basal lamina-forming and -non-forming myogenic cells in mouse skeletal muscle in relation to adhesive capacity and Pax7 expression in vitro.

Tamaki T, Tono K, Uchiyama Y, Okada Y, Masuda M, Soeda S, Nitta M, Akatsuka A.

Cell Tissue Res. 2011 Apr;344(1):147-68. doi: 10.1007/s00441-010-1127-9.


NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors.

Bustos F, de la Vega E, Cabezas F, Thompson J, Cornelison DD, Olwin BB, Yates JR 3rd, Olguín HC.

Stem Cells. 2015 Oct;33(10):3138-51. doi: 10.1002/stem.2125.


Deubiquitinating enzyme A20 negatively regulates NF-κB signaling in skeletal muscle in mdx mice.

Charan RA, Hanson R, Clemens PR.

FASEB J. 2012 Feb;26(2):587-95. doi: 10.1096/fj.11-189829. Erratum in: FASEB J. 2013 Jan;27(1):410.


Human satellite cells have regenerative capacity and are genetically manipulable.

Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvák Z, Spuler S.

J Clin Invest. 2014 Oct;124(10):4257-65. doi: 10.1172/JCI63992.


Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.

Alexakis C, Partridge T, Bou-Gharios G.

Am J Physiol Cell Physiol. 2007 Aug;293(2):C661-9.


miR-206 and -486 induce myoblast differentiation by downregulating Pax7.

Dey BK, Gagan J, Dutta A.

Mol Cell Biol. 2011 Jan;31(1):203-14. doi: 10.1128/MCB.01009-10. Erratum in: Mol Cell Biol. 2011 Mar;31(6):1329.


Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.

Calhabeu F, Hayashi S, Morgan JE, Relaix F, Zammit PS.

Oncogene. 2013 Jan 31;32(5):651-62. doi: 10.1038/onc.2012.73.

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