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Items: 1 to 20 of 96


Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.

Huh Y, Keep RF, Smith DE.

Antimicrob Agents Chemother. 2013 Dec;57(12):6171-8. doi: 10.1128/AAC.01497-13. Epub 2013 Sep 30.


Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice.

Shen H, Ocheltree SM, Hu Y, Keep RF, Smith DE.

Drug Metab Dispos. 2007 Jul;35(7):1209-16. Epub 2007 Apr 23.


Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow ECY, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ.

J Pharm Sci. 2014 Nov;103(11):3793-3805. doi: 10.1002/jps.24195. Epub 2014 Sep 29.


A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T.

Am J Physiol Renal Physiol. 2012 May 15;302(10):F1293-9. doi: 10.1152/ajprenal.00013.2012. Epub 2012 Feb 15.


Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure.

Komazawa H, Yamaguchi H, Hidaka K, Ogura J, Kobayashi M, Iseki K.

J Pharm Sci. 2013 Mar;102(3):1086-94. doi: 10.1002/jps.23433. Epub 2012 Dec 29.


Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein.

Nomura M, Motohashi H, Sekine H, Katsura T, Inui K.

Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1640-9. doi: 10.1152/ajprenal.00525.2011. Epub 2012 Mar 14.


JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats.

Guo X, Meng Q, Liu Q, Wang C, Sun H, Peng J, Ma X, Kaku T, Liu K.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):285-95. doi: 10.1016/j.taap.2013.04.029. Epub 2013 May 23.


Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites.

Zhong K, Li X, Xie C, Zhang Y, Zhong D, Chen X.

Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61. doi: 10.1128/AAC.02414-14. Epub 2014 May 12.


Oat1/3 restoration protects against renal damage after ischemic AKI.

Schneider R, Meusel M, Betz B, Held C, Möller-Ehrlich K, Büttner-Herold M, Wanner C, Gekle M, Sauvant C.

Am J Physiol Renal Physiol. 2015 Feb 1;308(3):F198-208. doi: 10.1152/ajprenal.00160.2014. Epub 2014 Nov 12.


Studies on the renal excretion mechanisms of cefadroxil.

Granero L, Gimeno MJ, Torres-Molina F, Chesa-Jiménez J, Peris JE.

Drug Metab Dispos. 1994 May-Jun;22(3):447-50.


Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).

Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. doi: 10.1124/jpet.110.170753. Epub 2010 Jun 2.


Regulation of renal sodium transporters during severe inflammation.

Schmidt C, Höcherl K, Schweda F, Kurtz A, Bucher M.

J Am Soc Nephrol. 2007 Apr;18(4):1072-83. Epub 2007 Feb 21.


Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats.

Schneider R, Sauvant C, Betz B, Otremba M, Fischer D, Holzinger H, Wanner C, Galle J, Gekle M.

Am J Physiol Renal Physiol. 2007 May;292(5):F1599-605. Epub 2007 Jan 23.


Cytokine-mediated regulation of urea transporters during experimental endotoxemia.

Schmidt C, Höcherl K, Bucher M.

Am J Physiol Renal Physiol. 2007 May;292(5):F1479-89. Epub 2007 Jan 16.


Oral availability of cefadroxil depends on ABCC3 and ABCC4.

de Waart DR, van de Wetering K, Kunne C, Duijst S, Paulusma CC, Oude Elferink RP.

Drug Metab Dispos. 2012 Mar;40(3):515-21. doi: 10.1124/dmd.111.041731. Epub 2011 Dec 13.


Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.

Mathialagan S, Piotrowski MA, Tess DA, Feng B, Litchfield J, Varma MV.

Drug Metab Dispos. 2017 Apr;45(4):409-417. doi: 10.1124/dmd.116.074294. Epub 2017 Feb 8.


Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue.

Nagle MA, Wu W, Eraly SA, Nigam SK.

Neurosci Lett. 2013 Feb 8;534:133-8. doi: 10.1016/j.neulet.2012.11.027. Epub 2012 Nov 27.


Differential effect of COX1 and COX2 inhibitors on renal outcomes following ischemic acute kidney injury.

Bischoff A, Bucher M, Gekle M, Sauvant C.

Am J Nephrol. 2014;40(1):1-11. doi: 10.1159/000363251. Epub 2014 Jun 17.


Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.

Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y.

Nucl Med Biol. 2013 Jul;40(5):643-50. doi: 10.1016/j.nucmedbio.2013.03.006. Epub 2013 Apr 22.


Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidney.

Wood CE, Cousins R, Zhang D, Keller-Wood M.

Exp Biol Med (Maywood). 2005 Oct;230(9):668-73.


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